Abstract: Provided herein are methods, compositions and uses involving T cell therapies, such as adoptive T cell therapy, and an inhibitor of a Diacylglycerol kinase (DGK). The provided methods, compositions and uses include those involving the administration or use of one or more DGK inhibitors (DGKi) in a combination therapy with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR) or T cell receptor (TCR).

Abstract: A manipulator for components, in particular sheet metal parts, includes a base body mountable stationarily or movable along a guide arrangement, a first pivot arm pivotally coupled to the base body via a horizontal first pivot axis, a second pivot arm pivotally coupled to the first pivot arm via a horizontal second pivot axis and a third pivot arm pivotally coupled to the second pivot arm via a horizontal third pivot axis. A first axis of rotation extending radially to the third pivot axis is formed on the third pivot arm. A gripper support arm is rotatably coupled to the third pivot arm via the first axis of rotation and extends radially to the first axis of rotation. A gripping arrangement is rotatably coupled to the gripper support arm via a second axis of rotation spaced from the first axis of rotation. A bending installation includes the manipulator.

Abstract: A method and a device for determining a radar cross section, a method for training an interaction model, a radar target emulator for manipulating a radar signal, and a test facility for a vehicle are described herein. The propagation of a virtual radar signal is simulated on the basis of an interaction model in a simulated environment scenario that contains the simulated radar target. An interaction of the virtual radar signal with the simulated radar target is modelled such that a physical variable, characterizing the virtual radar signal, is divided into a directional component that corresponds to a directed scattering of the virtual radar signal and into a diffuse component that corresponds to an isotropic scattering of the virtual radar signal.

Abstract: The present invention is related to crystalline salts of N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide, a RAF kinase Inhibitor, useful in the treatment of cancer and other diseases.

Abstract: A handheld diagnostic device, specifically for point-of-care applications. The handheld diagnostic device comprises at least one diagnostic measurement unit configured for performing at least one diagnostic measurement, the diagnostic measurement unit comprising at least one test element port for determining at least one diagnostic parameter of at least one patient by using at least one diagnostic test element; at least one camera configured for capturing at least one image of at least one wound of the patient; and at least one control unit, the control unit being configured for controlling the diagnostic measurement and for controlling the capturing of the image of the wound, wherein the control unit is further configured for storing at least one measurement result of the diagnostic measurement and the at least one image in at least one database record of the patient. A diagnostic system and a diagnostic method are further disclosed.

Abstract: A cold rolling machine and method for producing a profile on a workpiece. The cold rolling machine having two constructed tool units. Each tool unit has at least one rolling rod extending in the longitudinal direction, a tool slide, a slide drive device, a pivoting carrier and a pivot drive. The at least one rolling rod is fastened to the tool slide and can be moved in the longitudinal direction by the slide drive device. The pivoting carrier can be pivoted about a pivot axis extending in the longitudinal direction by a pivot drive. The tool slide is arranged on the pivoting carrier. An angle of inclination can thereby be set between the two rolling rods, which angle of inclination can have, for example, a value of 0 degrees to 2.0 degrees or to 0.2 degrees. Conical profiles can thereby be produced in the workpiece.

Abstract: The present invention is related to crystalline salts of N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide, a RAF kinase Inhibitor, useful in the treatment of cancer and other diseases.

Abstract: A method and a system for simulation-assisted determination of at least one actual echo point of an object, and a method and an emulation apparatus for emulating a detection target. Here, a predicted object reference point of the object and a predicted sensor device reference point of a sensor device, in particular a radar-based sensor device, are calculated on the basis of an actual object reference point and an actual sensor device reference point and a predicted echo point of the object is calculated on the basis of an emission characteristic of the sensor device, the predicted object reference point, and the predicted sensor device reference point. Moreover, a predicted relative relationship, in particular a spatial relative relationship, is calculated between the predicted echo point and the predicted object reference point.

Abstract: The present invention is related to crystalline salts of N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide, a RAF kinase Inhibitor, useful in the treatment of cancer and other diseases.

Abstract: The invention relates to a method for controlling a plurality of gas consumers (20, 21), comprising the following steps: assigning priorities to the gas consumers (20, 21), and activating or deactivating the gas consumers (20, 21) as a function of the priorities assigned. The invention further relates to a control device (1) for controlling gas consumers (20, 21).

Abstract: A cold rolling machine and method for producing a profile on a workpiece. The cold rolling machine having two constructed tool units. Each tool unit has at least one rolling rod extending in the longitudinal direction, a tool slide, a slide drive device, a pivoting carrier and a pivot drive. The at least one rolling rod is fastened to the tool slide and can be moved in the longitudinal direction by the slide drive device. The pivoting carrier can be pivoted about a pivot axis extending in the longitudinal direction by a pivot drive. The tool slide is arranged on the pivoting carrier. An angle of inclination can thereby be set between the two rolling rods, which angle of inclination can have, for example, a value of 0 degrees to 2.0 degrees or to 0.2 degrees. Conical profiles can thereby be produced in the workpiece.

Abstract: A method and a device for determining a radar cross section, a method for training an interaction model, a radar target emulator for manipulating a radar signal, and a test facility for a vehicle are described herein. The propagation of a virtual radar signal is simulated on the basis of an interaction model in a simulated environment scenario that contains the simulated radar target. An interaction of the virtual radar signal with the simulated radar target is modelled such that a physical variable, characterizing the virtual radar signal, is divided into a directional component that corresponds to a directed scattering of the virtual radar signal and into a diffuse component that corresponds to an isotropic scattering of the virtual radar signal.

Abstract: A rotary module for a measuring device of an accelerator facility includes a first radial bearing including a first bearing side configured to be paired with an accelerator-side flange connection and further including a second bearing side configured to receive the measuring device on the first radial bearing in a bearing manner such that the measuring device is connected to the accelerator facility by the first radial bearing; and a drive configured to control a rotational movement of the measuring device about an axis of rotation.

Abstract: The invention relates to a high-concentration mixer (1) for producing a suspension (2), comprising a stationary container (3) and an agitator (8) arranged in the container axis (7), which agitator is connected to a motor via a flange (9) provided in the region of the container bottom (4), which motor is designed for rotationally driving the agitator (8) for mixing the suspension (2) provided in the container (3), wherein the agitator (8) has helical coils (11) which bring about a vertical downward flow (12) of the suspension (2) in the centre of the container (3) and a vertical upward flow (13) of the suspension (2) in the region of the container wall, wherein the flange (9) comprises at least one blade (15) provided on its circumference, which is designed for wiping the suspension (2) from the container (3) and for supporting the vertical upward flow (13) of the suspension (2) in the region of the container wall.

Abstract: The present invention is related to crystalline salts of N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide, a RAF kinase Inhibitor, useful in the treatment of cancer and other diseases.

Abstract: A device for the transport of long-welded rails by way of a rail loading train, including an installation for the secured storage of the rails. The device is configured as a modular unit it has fastening devices for anchoring on a container flat car and includes a separate energy supply unit.

Abstract: A filter element for filtering a fluid has one or more filter bellows with a specified raw side and a specified clean side oppositely positioned relative to the specified raw side. The filter bellows has a filter medium that is folded along fold edges in a zigzag shape to folds, wherein the folds extend between oppositely positioned end edges of the at least one filter bellows, wherein the filter bellows has parallel extending end edge faces at oppositely positioned end faces. At least one pre-separator embodied as a flat mat is arranged at the raw side of the filter bellows. A frame is injection-molded from plastic material around the filter bellows and seals the end edge faces. The pre-separator is fastened to the raw side with fastening elements arranged at the frame. A filter system with a filter housing is provided with such a filter element.

Abstract: A method and a system for simulation-assisted determination of at least one actual echo point of an object, and a method and an emulation apparatus for emulating a detection target. Here, a predicted object reference point of the object and a predicted sensor device reference point of a sensor device, in particular a radar-based sensor device, are calculated on the basis of an actual object reference point and an actual sensor device reference point and a predicted echo point of the object is calculated on the basis of an emission characteristic of the sensor device, the predicted object reference point, and the predicted sensor device reference point. Moreover, a predicted relative relationship, in particular a spatial relative relationship, is calculated between the predicted echo point and the predicted object reference point.

Abstract: An anchoring device mechanism for anchoring rails includes a plurality of clamping jaws. The clamping jaws are connected to a jaw displacement device in order for the clamping jaws to be moved from a rail clamping position into a rail releasing position. A clamping drive unit is provided for moving the clamping jaws into the rail clamping position.

Abstract: A filter element, in particular for filtering the intake air of an internal combustion engine, is provided with a filter medium and a sealing device extending at least partially circumferentially around the filter medium, wherein the sealing device is made from a foamed thermoplastic elastomer, and wherein the sealing device is injection molded using a plastics injection molding method.