Abstract: Embodiments of the present invention encompass systems and methods for administering intrathoracic pressure and cooling treatments to patients suffering from or at risk of developing heart failure, cardiac arrest, sepsis, shock, acute respiratory distress syndrome, polytrauma, head disease, elevated hepatic or portal vein pressures, bleeding during abdominal, head and neck surgery, or insufficient circulation during open heart surgery.

Abstract: In one embodiment, the invention provides a method for performing cardiopulmonary resuscitation which comprises: 1) interfacing an airway system with a patient's airway, wherein the airway system includes at least a first lumen and a second lumen; 2) repeatedly performing CPR chest compressions on the patient; and simultaneously with the CPR chest compressions; 3) applying a continuous vacuum to the first lumen for a period of time ranging from 10 seconds to the end of the CPR chest compressions; and 4) injecting an effective volume of oxygen gas into the person's lungs at high velocity through the second lumen. In other embodiments, the invention provides a cardiopulmonary resuscitation system for use during the performance of CPR chest compressions on a patient, a novel locking supraglottic airway device, and a valve device for applying vacuum to a patient's airway.