Patents by Inventor Michael Malamas

Michael Malamas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ABHD6 and dual ABHD6/MGL inhibitors and their uses
    Patent number: 10662159
    Abstract: Provided herein are compounds and pharmaceutical compositions for selectively inhibiting serine hydrolase a/b-hydrolase domain 6 (ABHD6) and dually inhibiting ABHD6 and monoacylglycerol lipase (MGL). The compounds and pharmaceutical compositions disclosed herein are useful for treating a number of therapeutic conditions related to cannabinergic receptor function such as pain, inflammation, neuropathy, neurodegenerative diseases, anxiety disorders, motor function disorder, metabolic disorder, glaucoma and chemotherapy-induced nausea and vomiting and cancer.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: May 26, 2020
    Assignee: MAKSCIENTIFIC, LLC
    Inventors: Alexandros Makriyannis, Michael Malamas, Manjunath Lamani, Shrouq I. Farah
  • N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof
    Patent number: 10640494
    Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 5, 2020
    Assignee: NORTHEASTERN UNIVERSITY
    Inventors: Michael Malamas, Alexandros Makriyannis, Kumara Vadivel Subramanian, Kyle M. Whitten, Nikolai M. Zvonok, Jay Matthew West, Michael McCormack, Spiro Pavlopoulos
  • ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES
    Publication number: 20190152917
    Abstract: Provided herein are compounds and pharmaceutical compositions for selectively inhibiting serine hydrolase a/b-hydrolase domain 6 (ABHD6) and dually inhibiting ABHD6 and monoacylglycerol lipase (MGL). The compounds and pharmaceutical compositions disclosed herein are useful for treating a number of therapeutic conditions related to cannabinergic receptor function such as pain, inflammation, neuropathy, neurodegenerative diseases, anxiety disorders, motor function disorder, metabolic disorder, glaucoma and chemotherapy-induced nausea and vomiting and cancer.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Inventors: Michael Malamas, Alexandros Makriyannis, Manjunath Lamani, Shrouq I. Farah
  • N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof
    Publication number: 20180222894
    Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).
    Type: Application
    Filed: March 30, 2018
    Publication date: August 9, 2018
    Inventors: Michael Malamas, Alexandros Makriyannis, Kumara Vadivel Subramanian, Kyle M. Whitten, Nikolai M. Zvonok, Jay Matthew West, Michael McCormack, Spiro Pavlopoulos
  • N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof
    Patent number: 9963444
    Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: May 8, 2018
    Assignee: Northeastern University
    Inventors: Michael Malamas, Alexandros Makriyannis, Kumara Vadivel Subramanian, Kyle M. Whitten, Nikolai M. Zvonok, Jay Matthew West, Michael Mccormack, Spiro Pavlopoulos
  • N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof
    Publication number: 20170114050
    Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.
    Type: Application
    Filed: May 13, 2015
    Publication date: April 27, 2017
    Inventors: Michael Malamas, Alexandros Makriyannis, Kumara Vadivel Subramanian, Kyle M. Whitten, Nikolai M. Zvonok, Jay Matthew West, Michael Mccormack, Spiro Pavlopoulos
  • Indolylalkylpyridin-2-amines for the inhibition of beta-secretase
    Publication number: 20080076801
    Abstract: The present invention provides an indolylalkylpyridin-2-amine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 27, 2008
    Applicant: Wyeth
    Inventors: Yinfa Yan, Ping Zhou, Yi Fan, Albert Robichaud, Michael Malamas
  • Imidazole amines as inhibitors of beta-secretase
    Publication number: 20080051390
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: August 16, 2007
    Publication date: February 28, 2008
    Applicant: Wyeth
    Inventors: Michael Malamas, Keith Barnes, Matthew Johnson
  • Substituted benzoxazoles as estrogenic agents
    Publication number: 20070167503
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2006
    Publication date: July 19, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Robert McDevitt, Iwan Gunawan, Eric Manas, Michael Collini, Heather Harris, James Keith, Leo Albert, C. Richard Lyttle
  • Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase
    Publication number: 20070072925
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: September 25, 2006
    Publication date: March 29, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, William Fobare, Dominick Quagliato, Schuyler Antane, Albert Robichaud
  • Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation
    Publication number: 20070027199
    Abstract: The present invention provides a 2-amino-5-cycloalkyl-hydantoin compound of formula I The present invention also provides methods and compositions for the inhibition of ?-secretase (BACE) and the treatment of ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 1, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Iwan Gunawan, James Erdei, Pawel Nowak, Joseph Stock, Yinfa Yan
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation
    Publication number: 20070004786
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Ping Zhou, William Fobare, William Solvibile, Iwan Gunawan, James Erdei, Yinfa Yan, Patrick Andrae, Dominick Quagliato
  • Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
    Publication number: 20070004730
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Ping Zhou, Michael Malamas, Yanfang Li, Albert Robichaud, Dominick Quagliato
  • Amino-pyridines as inhibitors of beta-secretase
    Publication number: 20060173049
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 3, 2006
    Applicant: Wyeth
    Inventors: Michael Malamas, William Fobare, William Solvibile, Frank Lovering, Jeffrey Condon, Albert Robichaud
  • Amino-imidazolones for the inhibition of beta-secretase
    Publication number: 20060160828
    Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: January 13, 2006
    Publication date: July 20, 2006
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Pawel Nowak, Boyd Harrison
  • Diphenylimidazopyrimidine and -imidazole amines as inhibitors of beta-secretase
    Publication number: 20050282826
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Keith Barnes, Matthew Johnson, Yu Hui
  • Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
    Publication number: 20050282825
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Ping Zhou, Yinfa Yan, Dominick Quagliato
  • Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
    Publication number: 20050272786
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein, A is wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 30, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Iwan Gunawan, Heather Harris, James Keith, Leo Albert
  • Substituted benzoxazoles as estrogenic agents
    Publication number: 20050239851
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 27, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Robert McDevitt, Iwan Gunawan, Eric Manas, Michael Collini, Heather Harris, James Keith, Leo Albert, C. Lyttle
  • Phenyl benzisoxazoles as estrogenic agents
    Publication number: 20050159465
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 1, 2005
    Publication date: July 21, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Tam Dinh, Iwan Gunawan, Michael Collini, Heather Harris, James Keith, Leo Albert