Abstract: Described herein are methods and pharmaceutical formulations for treating dry eye disease.

Abstract: An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: -obtaining input of a series of logistically attainable PetX values for a series of respective breaths: -determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths; and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

Abstract: An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: —obtaining input of a series of logistically attainable PetX values for a series of respective breaths: —determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and—controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

Abstract: An apparatus includes feeds to form analog beams. The feeds are divided into panels. The apparatus includes processing circuitry that divides a target area for communications coverage into regions, including a first region and a second region neighboring each other. The processing circuitry generates, for the first region, a first plurality of analog beams, forming a first cluster. The processing circuitry generates, in the first cluster from the first plurality of analog beams, a first plurality of hybrid beams arranged in a first arrangement in the first cluster. The processing circuitry generates, for the second region, a second plurality of analog beams, forming a second cluster. The processing circuitry generates, in the second cluster from the second plurality of analog beams, a second plurality of hybrid beams arranged in a second arrangement that is adjacent to the first plurality of hybrid beams in the first arrangement.

Abstract: Information associated with a communication service need of the user is received from a user of a client computer system. A set of communication service requirements that indicate satellite resources required to satisfy the communication service need of the user are computed based on the received information, and transmitted to a server computer system. A first beam plan that satisfies the set of communication service requirements is received from the server computer system. The first beam plan includes information on satellite beams and spectra for allocation to the user when the first beam plan is deployed to provide a communication service to the user that satisfies the communication service need of the user. Instructions are transmitted to the server computer system to deploy the first beam plan. Information is received from the server computer system indicating that the first beam plan is deployed.

Abstract: An apparatus includes feeds to form analog beams. The feeds are divided into panels. The apparatus includes processing circuitry that divides a target area for communications coverage into regions, including a first region and a second region neighboring each other. The processing circuitry generates, for the first region, a first plurality of analog beams, forming a first cluster. The processing circuitry generates, in the first cluster from the first plurality of analog beams, a first plurality of hybrid beams arranged in a first arrangement in the first cluster. The processing circuitry generates, for the second region, a second plurality of analog beams, forming a second cluster. The processing circuitry generates, in the second cluster from the second plurality of analog beams, a second plurality of hybrid beams arranged in a second arrangement that is adjacent to the first plurality of hybrid beams in the first arrangement.

Abstract: An apparatus includes a plurality of feeds that form analog beams. The plurality of feeds is divided into a plurality of panels, each panel including one or more feeds from the plurality of feeds. The apparatus also includes processing circuitry, which determines a target area for communications coverage and divides the target area into a plurality of regions. The processing circuitry generates, for each region, a plurality of analog beams. A subset of panels of the plurality of panels generates one or more analog beams of the plurality of analog beams. The plurality of analog beams covering each region forms a cluster. The processing circuitry generates, in each cluster, one or more hybrid beams. Each hybrid beam is a digital beam that is generated by combining one or more analog beams of the plurality of analog beams corresponding to the cluster.

Abstract: An apparatus includes feeds to form analog beams. The feeds are divided into panels. The apparatus includes processing circuitry that divides a target area for communications coverage into regions, including a first region and a second region neighboring each other. The processing circuitry generates, for the first region, a first plurality of analog beams, forming a first cluster. The processing circuitry generates, in the first cluster from the first plurality of analog beams, a first plurality of hybrid beams arranged in a first arrangement in the first cluster. The processing circuitry generates, for the second region, a second plurality of analog beams, forming a second cluster. The processing circuitry generates, in the second cluster from the second plurality of analog beams, a second plurality of hybrid beams arranged in a second arrangement that is adjacent to the first plurality of hybrid beams in the first arrangement.

Abstract: An apparatus includes a plurality of feeds that form analog beams. The plurality of feeds is divided into a plurality of panels, each panel including one or more feeds from the plurality of feeds. The apparatus also includes processing circuitry, which determines a target area for communications coverage and divides the target area into a plurality of regions. The processing circuitry generates, for each region, a plurality of analog beams. A subset of panels of the plurality of panels generates one or more analog beams of the plurality of analog beams. The plurality of analog beams covering each region forms a cluster. The processing circuitry generates, in each cluster, one or more hybrid beams. Each hybrid beam is a digital beam that is generated by combining one or more analog beams of the plurality of analog beams corresponding to the cluster.

Abstract: Fade conditions are determined for each gateway in gateway clusters of a set of gateway clusters. A proper subset of the gateway clusters is selected based on the fade conditions determined for each gateway. A beam plan is determined based on the proper subset of the gateway clusters. The beam plan is executed.

Abstract: A beam plan that defines beams generated by a satellite that satisfy a set of communication service requirements is obtained. Fade condition information that indicates an amount of fade at particular geographic areas for one or more of the beams is obtained. A modification to the beam plan that mitigates the amount of fade at the particular geographic areas for the one or more of the beams is determined. The beam plan is modified based on the determined modification.

Abstract: Fade conditions are determined for each gateway in gateway clusters of a set of gateway clusters. A proper subset of the gateway clusters is selected based on the fade conditions determined for each gateway. A beam plan is determined based on the proper subset of the gateway clusters. The beam plan is executed.

Abstract: An apparatus includes a plurality of feeds that form analog beams. The plurality of feeds is divided into a plurality of panels, each panel including one or more feeds from the plurality of feeds. The apparatus also includes processing circuitry, which determines a target area for communications coverage and divides the target area into a plurality of regions. The processing circuitry generates, for each region, a plurality of analog beams. A subset of panels of the plurality of panels generates one or more analog beams of the plurality of analog beams. The plurality of analog beams covering each region forms a cluster. The processing circuitry generates, in each cluster, one or more hybrid beams. Each hybrid beam is a digital beam that is generated by combining one or more analog beams of the plurality of analog beams corresponding to the cluster.

Abstract: An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

Abstract: Information associated with a communication service need of the user is received from a user of a client computer system. A set of communication service requirements that indicate satellite resources required to satisfy the communication service need of the user are computed based on the received information, and transmitted to a server computer system. A first beam plan that satisfies the set of communication service requirements is received from the server computer system. The first beam plan includes information on satellite beams and spectra for allocation to the user when the first beam plan is deployed to provide a communication service to the user that satisfies the communication service need of the user. Instructions are transmitted to the server computer system to deploy the first beam plan. Information is received from the server computer system indicating that the first beam plan is deployed.

Abstract: The present invention relates to the use of neutral lipids, including triglycerides, diglycerides and monoglycerides which may be used to increase neutral lipids (lipid stores and/or lipid droplets) and neutral lipid stores in order to regulate (in particular, induce) autophagy and treat and/or prevent autophagy related disease states and/or conditions. In one embodiment, the invention relates to the use of neutral lipids and/or TRIM proteins which may be used to regulate (in particular, induce) autophagy, target autophagic substrates and treat and/or prevent autophagic disease states and/or conditions.

Abstract: Beamforming in a satellite communications network includes determining a first delay imparted to signals redirected by a first reflecting dish in a satellite, the first delay being caused by motion of the first reflecting dish relative to the satellite. A second delay imparted to signals redirected by a second reflecting dish in the satellite is determined, the second delay being caused by motion of the second reflecting dish relative to the satellite. Calculating, using the determined first and second delays, beamforming coefficients that enable the generation of a single beam by combining a group of signals that includes a first signal redirected by the first reflecting dish and a second signal redirected by the second reflecting dish.

Abstract: Information associated with a communication service need of the user is received from a user of a client computer system. A set of communication service requirements that indicate satellite resources required to satisfy the communication service need of the user are computed based on the received information, and transmitted to a server computer system. A first beam plan that satisfies the set of communication service requirements is received from the server computer system. The first beam plan includes information on satellite beams and spectra for allocation to the user when the first beam plan is deployed to provide a communication service to the user that satisfies the communication service need of the user. Instructions are transmitted to the server computer system to deploy the first beam plan. Information is received from the server computer system indicating that the first beam plan is deployed.

Abstract: An apparatus includes feeds to form analog beams. The feeds are divided into panels. The apparatus includes processing circuitry that divides a target area for communications coverage into regions, including a first region and a second region neighboring each other. The processing circuitry generates, for the first region, a first plurality of analog beams, forming a first cluster. The processing circuitry generates, in the first cluster from the first plurality of analog beams, a first plurality of hybrid beams arranged in a first arrangement in the first cluster. The processing circuitry generates, for the second region, a second plurality of analog beams, forming a second cluster. The processing circuitry generates, in the second cluster from the second plurality of analog beams, a second plurality of hybrid beams arranged in a second arrangement that is adjacent to the first plurality of hybrid beams in the first arrangement.

Abstract: A beam plan that defines beams generated by a satellite that satisfy a set of communication service requirements is obtained. Fade condition information that indicates an amount of fade at particular geographic areas for one or more of the beams is obtained. A modification to the beam plan that mitigates the amount of fade at the particular geographic areas for the one or more of the beams is determined. The beam plan is modified based on the determined modification.