Abstract: The disclosure provides an ocular drug delivery system that includes a contact lens and a drug delivery portion, which may include a compound having the formula X—(CH2)n-Z, wherein X is a photocrosslinkable group. Advantageously, the drug delivery portion may aid in loading a high concentration of a negatively-charged therapeutic agent into the ocular drug delivery system. Additionally, the disclosed ocular drug delivery system may aid in controlled delivery of the negatively-charged therapeutic agent to the eye of a patient over a period of about 4 to about 24 hours.

Abstract: Contact lenses are provided for ocular iontophoretic therapy. Implementations include a reservoir adapted to contain a charged therapeutic compound, a current source providing iontophoretic current to the charged therapeutic composition to affect delivery of the charged therapeutic composition into an eyeball, and a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition. Alternate embodiments include active, sacrificial electrodes for generating ions sufficient to provide electromotive repulsive force to the charged compound to effect transport into ocular tissue.

Abstract: Compositions, devices, method of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides and electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least on buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multi-particulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including on or more layers and one or more concentric cylinders.

Abstract: Contact lenses are provided for ocular iontophoretic therapy. Implementations include a reservoir adapted to contain a charged therapeutic compound, a current source providing iontophoretic current to the charged therapeutic composition to affect delivery of the charged therapeutic composition into an eyeball, and a sensing circuit controlling the current source to maintain a selected pH range of the charged therapeutic composition. Alternate embodiments include active, sacrificial electrodes for generating ions sufficient to provide electromotive repulsive force to the charged compound to effect transport into ocular tissue.

Abstract: Compositions, devices, method of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides and electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least on buffer elementt, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multi-particulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including on or more layers and one or more concentric cylinders.

Abstract: Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.

Abstract: A clip and a method for using the clip is shown and described herein. The clip may include a base, a pair of flaps, a pair of arms and at least one wing. The pair of flaps may be mutually confronting and extend outwardly from the base, wherein each flap includes a tab. The pair of arms may be mutually confronting and extend outwardly from the base, wherein each arm includes a tab. The method may utilize a clip to secure a first component to a second component. The method may include rotating the clip or the first component in a first direction thereby securing each other together. The second component may be placed onto the clip. The first component and clip may be serviceable by rotating the first component in a second direction opposite that of the first to remove the first component from the clip.

Abstract: Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.

Abstract: The present invention is directed to a clip and a method for using the clip. The clip may include a base, a pair of flaps, a pair of arms and at least one wing. The pair of flaps may be mutually confronting and extend outwardly from the base, wherein each flap includes a tab. The pair of arms may be mutually confronting and extend outwardly from the base, wherein each arm includes a tab. The method may utilize a clip to secure a first component to a second component. The method may include rotating the clip or the first component in a first direction thereby securing each other together. The second component may be placed onto the clip. The first component and clip may be serviceable by rotating the first component in a second direction opposite that of the first to remove the first component from the clip.

Abstract: A communication remote control system allows a user to remotely configure call management functions across various phone networks using a client device. The communication remote control system centrally handles call management for the user's telephones. The communication remote control system may provide a centralized address book, call log, and voicemail. The user can specify various parameters including modes, filters, schedules, and the like, which are stored in the communication remote control system. The communication remote control system routes incoming calls made to the phone networks to the user's delivery device, which may be part of the client device. Incoming calls are routed to a specified telephone number, sent to voicemail, or otherwise disposed of or users can change modes manually or can specify automatic mode selection based on time of date, day of week, location, and/or other factors.

Abstract: A personal call management system allows a user to specify how incoming telephone calls should be handled. The user can specify various parameters including modes, filters, schedules, and the like. Incoming calls are routed to a specified telephone number, or sent to voicemail, or otherwise disposed of. Users can change modes manually or can specify automatic mode selection based on time of date, day of week, location, and/or other factors.

Abstract: A system and method automatically route telephone calls to a substitute telephone number that may differ from the dialed telephone number. The substitute telephone number is obtained from a call management module which determines the number based on various factors including, for example, modes, filters, schedules, and the like. A dynamic number portability database may be used to implement the call routing functionality.

Abstract: A system and method provide callee activity mode information to a caller (including a potential caller). Thus the caller can find out the current callee activity mode, and the callee's availability to receive telephone calls. Callees can configure the system and method to provide different types of information depending on various factors including caller identity. The invention provides functionality for displaying callee activity mode information after a call is attempted, or before it is attempted, or both.