Patents by Inventor Michael Marden

Michael Marden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11662303
    Abstract: The aim of the present invention is to propose a novel method for spectral study of a biological fluid from an absorption spectrum of a sample of the biological fluid. The inventors have made an original use of spectroscopy in order to accurately determine the protein content of a biological sample, in particular for oxyhaemoglobin, methaemoglobin, bilirubin and the haem bound to serum albumin. Such a method can be used in a variety of applications concerning haem- or haemoprotein- related diseases, in particular diagnostic methods, treatment follow-up methods, methods for determining biomarkers or screening methods. Such a method is also advantageous for qualifying blood bags.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 30, 2023
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Laurent Kiger, Michael Marden, Pablo Bartolucci, France Pirenne
  • Publication number: 20220011217
    Abstract: A method for determining at least one protein in the blood which is more precise while still being simple to implement. The method exploits in an original way the spectroscopy and the dosing techniques to determine accurately the content in proteins of the biological sample, notably for oxyhemoglobin, methemoglobin, heme bound to serum albumin and hemopexin and bilirubin. Such method can advantageously be used in various applications concerning heme-related or hemoprotein-related disorders, notably method for diagnosing, for following a treatment, for determining biomarkers or for screening. Such a method is also interesting for qualifying blood bags.
    Type: Application
    Filed: November 29, 2019
    Publication date: January 13, 2022
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ PARIS EST CRÉTEIL VAL DE MARNE, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: Laurent KIGER, Pablo BARTOLUCCI, Michael MARDEN
  • Publication number: 20200340913
    Abstract: The aim of the present invention is to propose a novel method for spectral study of a biological fluid from an absorption spectrum of a sample of the biological fluid. The inventors have made an original use of spectroscopy in order to accurately determine the protein content of a biological sample, in particular for oxyhaemoglobin, methaemoglobin, bilirubin and the haem bound to serum albumin. Such a method can be used in a variety of applications concerning haem- or haemoprotein- related diseases, in particular diagnostic methods, treatment follow-up methods, methods for determining biomarkers or screening methods. Such a method is also advantageous for qualifying blood bags.
    Type: Application
    Filed: November 30, 2018
    Publication date: October 29, 2020
    Inventors: Laurent KIGER, Michael MARDEN, Pablo BARTOLUCCI, France PIRENNE
  • Publication number: 20060182807
    Abstract: The invention relates to novel compounds, characterized in that they comprise a hemoprotein which is associated with a sequenced block copolymer, comprising an hydrophilic segment which is an oligo or polysaccharide linked to at least one hydrophobic segment of formula (1) wherein x represents H or an radical which is alkyl, CN or CONHR, Y represents a COOR?, CONHR? or C6H5 radical, wherein R, R? and R? represent, independently from each other, a hydrogen atom, a C1-C20 linear ou branched alkyl group, a C1-C20 linear or branched alcoxy group, an amino acid radical, a mono- or poly-hydroxyl acid radical or an aryl ou heteroaryl C5-C12 radical, and forms associated with a gas. The invention can be used as blood substitutes and depolluting agents.
    Type: Application
    Filed: June 10, 2003
    Publication date: August 17, 2006
    Inventors: Christine Vauthier, Cedric Chauvierre, Patrick Couvreur, Denis Labarre, Liliane Leclerc, Michael Marden
  • Patent number: 6916787
    Abstract: A method for producing haemin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of an animal haemin protein capable of reversibly binding oxygen, or for a variant or portion of said protein component, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the haemin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying a haemin protein that includes a complex consisting of the protein or proteins coded for by said nucleic acid and at least one iron-containing porphyritic nucleus, or a plurality of such complexes.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: July 12, 2005
    Assignees: Institut National de la Sante et de Recherche Medicale, Meristern Therapeutics
    Inventors: Bertrand Merot, Wilfrid Dieryck, Philippe Lenee, Michael Marden, Veronique Gruber, Renee-Josee Pagnier, Sylvie Baudino, Claude Poyart
  • Patent number: 6344600
    Abstract: A method for producing human hemoglobin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of a human hemoglobin protein capable of reversibly binding oxygen, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the human hemoglobin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying the human hemoglobin protein that includes a complex consisting of the protein or proteins coded for by the nucleic acid and at least one iron-containing polphyritic nucleus, or a plurality of such complexes.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: February 5, 2002
    Assignees: Meristem Therapeutics, Institut National de la Sante et de la Recherche Medicale
    Inventors: Bertrand Merot, Wilfrid Dieryck, Philippe Lenee, Michael Marden, Veronique Gruber, Renee-Josee Pagnier, Sylvie Baudino, Claude Poyart