Patents by Inventor Michael Marie Kaufman-Schofield

Michael Marie Kaufman-Schofield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nonribosomal peptide synthetases
    Patent number: 9994885
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: June 12, 2018
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Baulamycins, compositions and methods of use thereof
    Patent number: 9803187
    Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: October 31, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ASOCIACION INSTITUTO NACIONAL DE BIODIVERSIDAD
    Inventors: David H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz
  • NONRIBOSOMAL PEPTIDE SYNTHETASES
    Publication number: 20170044582
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Application
    Filed: January 22, 2015
    Publication date: February 16, 2017
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • Nonribosomal peptide synthetases
    Patent number: 9487763
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 8, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • NONRIBOSOMAL PEPTIDE SYNTHETASES
    Publication number: 20150361470
    Abstract: The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
    Type: Application
    Filed: May 15, 2015
    Publication date: December 17, 2015
    Inventors: David H. Sherman, Michael Marie Kaufman-Schofield, Sunit Jain, Gregory Dick
  • BAULAMYCINS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20150337288
    Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
    Type: Application
    Filed: May 20, 2015
    Publication date: November 26, 2015
    Inventors: David H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz