Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: A method for producing a flowable active material-encapsulated core-shell microcapsule composition by mechanically removing solvent from a microcapsule suspension to produce a wet cake, and subsequently charging the wet cake with a dry flow aid, is provided.

Abstract: A plurality of device-sharing participants may be detected that are participating in a videoconference via a shared computing device. The detecting of the plurality of device-sharing participants may be performed based, at least in part, on at least one of an audio analysis of captured audio from one or more microphones or a video analysis of captured video from one or more cameras. A plurality of participant connections corresponding to the plurality of device-sharing participants may be joined to the videoconference. Each of the plurality of participant connections may be identified within the videoconference using a respective name. A plurality of video streams and a plurality of audio streams corresponding to the plurality of participant connections may be transmitted, and the plurality of video streams and the plurality of audio streams may be presented to at least one other conference participant.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: A multi-stroke reciprocating thermal engine includes a cylinder head; a cylinder head cover; a crank case; crank shaft; a cam shaft; a cam cover; piston heads; and Shape Memory Alloy compression springs; a fluid tank; a radiator; a fluid pump; a heating fluid and a cooling fluid; a thermal battery with a thermal mass for storing thermal energy; a means of charging the thermal battery including a solar lens; electrical charging means and electromagnetic induction means.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of titanium diboride. There is also described a method of manufacturing the component and the application of TiB2 as a release agent in high-temperature applications.

Abstract: A hybrid electric propulsion (HEP) system can include a heat engine torque sensor connected between a heat engine and a combining gear box to sense a heat motor input torque input to the combining gear box, an electric motor torque sensor connected between an electric motor and the combining gear box to sense an electric motor input torque input to the combining gear box, and a combining gear box torque sensor connected to an output of the combining gearbox. The system can include a HEP controller operatively connected to each of the heat engine torque sensor, the electric motor torque sensor, and the combining gear box torque sensor to receive one or more torque signals therefrom. The controller can be configured to output one or more output signals as a function of the signals from each of the heat engine torque sensor, the electric motor torque sensor, and the combining gear box torque sensor.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of yttria. There is also described a method of manufacturing a coated component, and the application of Y2O3 as a release agent in high temperature applications.

Abstract: A plurality of talker embedding vectors may be derived that correspond to a plurality of talkers in an input audio stream. Each talker embedding vector may represent respective voice characteristics of a respective talker. The talker embedding vectors may be generated based on, for example, a pre-enrollment process or a cluster-based embedding vector derivation process. A plurality of instances of a personalized noise suppression model may be executed on the input audio stream. Each instance of the personalized noise suppression model may employ a respective talker embedding vector. A plurality of single-talker audio streams may be generated by the plurality of instances of the personalized noise suppression model. A plurality of single-talker transcriptions may be generated based on the plurality of single-talker audio streams. The plurality of single-talker transcriptions may be merged into a multi-talker output transcription.

Abstract: Joint noise and echo suppression may be performed for enhancing two-way audio communications. Audio data is captured at a communication device and audio data transmitted to the communication device from another communication device are used as input features to a trained machine learning model that uses the transmitted audio data as a reference signal to eliminate residual echo in the captured audio data when also suppressing noise in the captured audio data.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: A propulsion system includes a uniform shape-shifting rotating disc member that changes its mass distribution at particular angular arc segment in a radial direction due to an electromagnetic field acting upon that angular arc segment, with no eccentric mechanical trajectory to guide a mass being required. The disc member has a multiplicity of shape-shifting arc segments that can respond to electromagnetic fields acting on them. Each shape-shifting arc segment passes a shape-shifting region of the apparatus at a frequency of rotation of the encoded motor multiplied by the number of such arc segment.

Abstract: A videoconference among a plurality of participants may be hosted, wherein the plurality of participants comprise Internet Protocol (IP)-connected participants and a Public Switched Telephone Network (PSTN)-connected participant. The IP-connected participants may send and receive audio content and video content of the videoconference via IP-based connections. The PSTN-connected participant may send and receive the audio content of the videoconference via a PSTN connection. Additional content from the videoconference may also be transmitted to the PSTN-connected participant, for example as text messages via the PSTN connection. The additional content may include, for example, images of a videoconference screen share, chat posts, polls, and the like. Images may be transmitted in the additional content based on video status change events, such as switching slides or pages in a screen share.

Abstract: A novel self-cooling food product container apparatus (10) and a process for manufacturing the same is disclosed. A self-cooling food product container (20) combined with a substantive vapor transport system producing a humidification cooling process for cooling food and beverage products P. Methods of assembling and operating the apparatus (10) are also provided.

Abstract: A hybrid electric propulsion (HEP) system can include a heat engine torque sensor connected between a heat engine and a combining gear box to sense a heat motor input torque input to the combining gear box, an electric motor torque sensor connected between an electric motor and the combining gear box to sense an electric motor input torque input to the combining gear box, and a combining gear box torque sensor connected to an output of the combining gearbox. The system can include a HEP controller operatively connected to each of the heat engine torque sensor, the electric motor torque sensor, and the combining gear box torque sensor to receive one or more torque signals therefrom. The controller can be configured to output one or more output signals as a function of the signals from each of the heat engine torque sensor, the electric motor torque sensor, and the combining gear box torque sensor.

Abstract: Real-time low-complexity stereo speech enhancement with spatial cue preservation may be performed. A stereo speech enhancement system receives a stereo input signal (e.g., a left and right input signal). The stereo speech enhancement system estimates spatial cues for a target speaker and downmixes the stereo input signal into a monaural signal. A low-complexity model may then process the monaural signal to generate an enhanced monaural signal. The stereo speech enhancement system upmixes the enhanced monaural signal based on the estimated spatial cues for the target speaker, to generate an enhanced stereo output signal.