Abstract: Vertical etch heterolithic integrated circuit devices are described. A method of manufacturing NIP diodes is described in one example. A P-type substrate is provided, and an intrinsic layer is formed on the P-type substrate. An oxide layer is formed on the intrinsic layer, and one or more openings are formed in the oxide layer. One or more N-type regions are implanted in the intrinsic layer through the openings in the oxide layer. The N-type regions form cathodes of the NIP diodes. A dielectric layer deposited over the oxide layer is selectively etched away with the oxide layer to expose certain ranges of the intrinsic layer to define a geometry of the NIP diodes. The intrinsic layer and the P-type substrate are vertically etched away within the ranges to expose sidewalls of the intrinsic layer and the P-type substrate. The P-type substrate forms the anodes of the NIP diodes.

Abstract: One aspect can provide a direct current (DC) feedback circuit. The DC feedback circuit can include a gain path, a first feedback capacitor coupled, in parallel, to the gain path, and an input resistor coupled to an input of the gain path and the first feedback capacitor. The gain path can include an input stage with a pair of transconductance amplifiers, a gain stage with one or more amplifiers, and an output stage with at least one negative feedback amplifier.

Abstract: This relates to methods for measuring irregularities in a signal and corresponding devices. The devices can include a PPG sensor unit configured to detect multiple occurrences of a given event in the measured signal(s) over a sampling interval. In some instances, the device can register the occurrences of the events. In some examples, the device can include one or more motion sensors configured to detect whether the device is in a low-motion state. The device may delay initiating measurements when the device is not in a low-motion state to enhance measurement accuracy. Examples of the disclosure further include resetting the sample procedure based on one or more factors such as the number of non-qualifying measurements. In some examples, the device can be configured to perform both primary and secondary measurements, where the primary measurements can include readings using a set of operating conditions different from the secondary measurements.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.

Abstract: A device having an armature including a main wall; a rotary part intended to be mechanically coupled to a control shaft of an electrical switching unit; a bar integral with the rotary part and able to rotate between a first position and a second position and extending through a slot in the main wall; a position sensor having a movable contact pushed into a retracted position by the bar when the bar is in the first position; a stabilizing device having a resilient strip extending along the slot in order to exert a retaining force on the bar when it is in the first position.

Abstract: A device having an armature including a main wall; a rotary part intended to be mechanically coupled to a control shaft of an electrical switching unit; a bar integral with the rotary part and able to rotate between a first position and a second position and extending through a slot in the main wall; a position sensor having a movable contact pushed into a retracted position by the bar when the bar is in the first position; a stabilizing device having a resilient strip extending along the slot in order to exert a retaining force on the bar when it is in the first position.

Abstract: An air circuit breaker includes two separable electrical contacts connected to electric current input and output terminals; and a chamber for quenching an electric arc, including a stack of splitter plates that are spaced apart from one another, and lateral walls placed on either side of the stack and including a thermosetting-resin impregnated polyamide woven and being devoid of glass fibres. The quenching chamber furthermore includes protective elements made of crosslinked polyamide, the elements being placed in junction zones between the lateral walls and holding plates, the protective elements covering corners of the splitter plates, which corners are adjacent to the lateral walls, so as to separate these corners of the splitter plates from the electrical contacts.

Abstract: A pluggable electrical device for switching an electrical current includes a static frame including a rigid backplate fastened to the frame; connection terminals able to be connected to an electrical installation; and a removable portion including a device for switching an electrical current. The backplate is made of a thermosetting polymer and includes reinforcing beams integrated into the backplate and extending in a vertical direction.

Abstract: An air circuit breaker includes two separable electrical contacts connected to electric current input and output terminals; and a chamber for quenching an electric arc, including a stack of splitter plates that are spaced apart from one another, and lateral walls placed on either side of the stack and including a thermosetting-resin impregnated polyamide woven and being devoid of glass fibres. The quenching chamber furthermore includes protective elements made of crosslinked polyamide, the elements being placed in junction zones between the lateral walls and holding plates, the protective elements covering corners of the splitter plates, which corners are adjacent to the lateral walls, so as to separate these corners of the splitter plates from the electrical contacts.

Abstract: A pluggable electrical device for switching an electrical current includes a static frame including a rigid backplate fastened to the frame; connection terminals able to be connected to an electrical installation; and a removable portion including a device for switching an electrical current. The backplate is made of a thermosetting polymer and includes reinforcing beams integrated into the backplate and extending in a vertical direction.

Abstract: A dry powder pharmaceutical composition comprising (i) a medicament particle fraction comprising medicament particles with an aerodynamic diameter no greater than 10 ?m; and (ii) at least 50% of a non-respirable excipient fraction comprising low density excipient particles with an aerodynamic diameter greater than 10 ?m and a geometric diameter greater than 30 ?m. In additional embodiments of the invention, the pharmaceutical composition includes a respirable excipient fraction comprising excipient particles with an aerodynamic diameter no greater than 10 ?m. In a preferred embodiment of the invention, the non-respirable excipient particles include pores adapted to receive a portion of the respirable excipient fraction and/or the medicament fraction.

Abstract: A laminate assembly, comprising a base sheet having at least one blister formed therein, a pharmaceutical composition displaced in the blister, a lid sheet bonded to the base sheet to form a primary seal therebetween, thus forming a primarily sealed laminate assembly; the primary sealed laminate assembly having a secondary seal formed therein, and related manufacturing method and system of manufacture.

Abstract: A dry powder pharmaceutical composition comprising (i) a medicament particle fraction comprising medicament particles with an aerodynamic diameter no greater than 10 &mgr;m; and (ii) at least 50% of a non-respirable excipient fraction comprising low density excipient particles with an aerodynamic diameter greater than 10 &mgr;m and a geometric diameter greater than 30 &mgr;m. In additional embodiments of the invention, the pharmaceutical composition includes a respirable excipient fraction comprising excipient particles with an aerodynamic diameter no greater than 10 &mgr;m. In a preferred embodiment of the invention, the non-respirable excipient particles include pores adapted to receive a portion of the respirable excipient fraction and/or the medicament fraction.