Abstract: An imaging structure identification system includes an optical imaging system configured to illuminate a liquid biopsy sample for a subject. The liquid biopsy sample has one or more biological structures that are labeled with one or more fluorophores associated with a fluorescence assay for a disease state allowing detection of emitted electromagnetic radiation from the liquid biopsy sample as image data. The system also includes a processing system configured to identifying the subject as being at reduced risk for having the disease state if the subject profile is similar to the first predetermined profile for subjects not being in the disease state. However, if the subject profile is not similar to the first predetermined profile for subjects not being in the disease state it is not determinative if the subject is in the disease state.

Abstract: An apparatus that may be used to allow the rotation of a component that passes through a wall of a vacuum chamber is disclosed. The apparatus includes a rotatable shaft through which the component passes. The rotatable shaft is held in place using a holder, which retains a portion of the rotatable shaft. In some embodiments, the holder is affixed to a plate, which is then affixed to the chamber wall. The plate has an opening which is aligned to the opening in the chamber wall. A portion of the rotatable shaft passes through the opening in the plate and vacuum seals are disposed between the rotatable shaft and the plate. This apparatus may be used to allow use of rotatable components in an ion implanter.

Abstract: Some embodiments of the present disclosure provide, as part of a user interface related to the fulfillment of an order, a user interface component that, when activated, causes transmission of a request to cancel the order. According to a specific configuration, receipt of a notification related to commencement of a “threshold” step in a process of fulfilling the order causes the user interface component to be disabled. Notably, by appropriately selecting the threshold step in the process of fulfilling the order, costs related to cancelling orders may be optimized while still providing enhanced order-cancelling flexibility to customers.

Abstract: Hip implant systems described herein can include a distal stem, a proximal body, and a fastener. In some embodiments, the distal stem can include a cavity configured to receive the fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, the distal stem can include a threaded exterior surface configured to mate with a fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, a distal end of the distal stem can include an anterior relief configured to conform to interior surface of a femoral canal of a patient.

Abstract: An ion implantation system including an ion source for generating an ion beam, an end station containing a platen for supporting a substrate to be implanted by the ion beam, and a load lock disposed adjacent the end station and adapted to transfer substrates between an external environment and the end station. The load lock may include a transfer chamber having a hollow interior, a first isolation door affixed to a first side of the transfer chamber and openable to the external environment, a second isolation door affixed to a second side of the transfer chamber and openable to an interior of the end station, and a volume filling cassette disposed within the hollow interior of the transfer chamber and adapted to hold at least one substrate.

Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.

Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: This application describes the creation of a wheel disc for a trailer using a three-hit manufacturing process.

Abstract: A temperature-robust polymer shroud for a roller bearing seal includes a shroud body and an inner diameter leg defining respective portions of a single continuous part. The shroud body encircles a rotation axis of the polymer shroud and extends predominantly in directions orthogonal to the rotation axis from an inner diameter to an outer diameter. The inner diameter leg connects to the shroud body at the inner diameter and encircles the rotation axis, wherein, along the entire inner diameter of the shroud body, the inner diameter leg is oriented at an oblique angle to the rotation axis to extend both (a) radially inward from the inner diameter and (b) axially away from the inner diameter along a first direction parallel to the rotation axis. A roller bearing seal includes a seal case, an elastomer lip, and the temperature-robust polymer shroud.

Abstract: In accordance with one aspect of the present disclosure, a wear ring assembly is provided for a railway roller bearing. The wear ring assembly includes a wear ring having a central opening for receiving a journal of a railway wheel assembly and an insert including a plurality of spacers configured to extend in the opening of the wear ring to separate the wear ring from the journal. The spacers are spaced apart from each other about the wear ring. The insert may include one or more flanges that separate the wear ring from a bearing cone.

Abstract: Disclosed are methods, kits and cells for screening for test compounds that are capable of inhibiting DNA-binding activity of a DNA-binding protein. The disclosed methods, kits and cells may include a reporter expression cassette that encodes a reporter expression product, wherein the reporter expression cassette comprises at least one binding site for the DNA-binding protein such that binding of the DNA-binding protein to the binding site inhibits expression of the reporter expression product. Also disclosed are methods for producing a helix-constrained peptide that may be used in the screening methods disclosed herein. The methods, kits and cells find application, for example, in the identification of antagonists that may be useful in the treatment of cancers involving the DNA-binding protein.

Abstract: Hip implant systems described herein can include a distal stem, a proximal body, and a fastener. In some embodiments, the distal stem can include a cavity configured to receive the fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, the distal stem can include a threaded exterior surface configured to mate with a fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, a distal end of the distal stem can include an anterior relief configured to conform to interior surface of a femoral canal of a patient.

Abstract: Presented herein is an online marketplace for the selling and delivering of items for sale. The online marketplace includes devices and systems as well as their methods of use for the online purchase of goods as well as for the efficient and expedient delivery of the goods purchased. In particular embodiments, the system may include a cloud based database that stores images of the items for purchase, and may further include an associated computing device that is configured for receiving data corresponding with the one or more physical items represented by the images of the goods for sale that are stored in the database. The computing device is further configured for displaying the data corresponding with the one or more physical items for sale, e.g.

Abstract: In accordance with one aspect of the present disclosure, a wear ring assembly is provided for a railway roller bearing. The wear ring assembly includes a wear ring having a central opening for receiving a journal of a railway wheel assembly and an insert including a plurality of spacers configured to extend in the opening of the wear ring to separate the wear ring from the journal. The spacers are spaced apart from each other about the wear ring. The insert may include one or more flanges that separate the wear ring from a bearing cone.

Abstract: An intramedullary based & omni-positionable cutting guide instrumentation for femoral epiphysis resection for knee prosthesis placement comprising: an intramedullary placement guide (1,27) in a medullary cavity of a femoral epiphysis having an anterior/posterior adjustment mechanism (33); posterior rotational referencing sizing jig (8) for fastening to the anterior/posterior adjustment mechanism (33) and configured for referencing anterior (10) and posterior (11, 18) surfaces of the femoral epiphysis to adjust the anterior/posterior offset of the anterior/posterior adjustment mechanism (33); and a punch card (20) for subsequent fastening to the anterior/posterior adjustment mechanism (33) and comprising a plurality of position referencing apertures (21a-21d) for receipt of at least one locking pin (23) of a cutting block guide (5) to allow the anterior/posterior positioning of the cutting block guide (5) at a first position (e.g. FIG. 10) for making a first resection (e.g. 24) and at a second position (e.

Abstract: Presented herein is an online marketplace for the selling and delivering of items for sale. The online marketplace includes devices and systems as well as their methods of use for the online purchase of goods as well as for the efficient and expedient delivery of the goods purchased. In particular embodiments, the system may include a cloud based database that stores images of the items for purchase, and may further include an associated computing device that is configured for receiving data corresponding with the one or more physical items represented by the images of the goods for sale that are stored in the database. The computing device is further configured for displaying the data corresponding with the one or more physical items for sale, e.g.

Abstract: Hip implant systems described herein can include a distal stem, a proximal body, and a fastener. In some embodiments, the distal stem can include a cavity configured to receive the fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, the distal stem can include a threaded exterior surface configured to mate with a fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, a distal end of the distal stem can include an anterior relief configured to conform to interior surface of a femoral canal of a patient.

Abstract: An altimeter apparatus for an aircraft includes an altimeter circuit and can use a method of determining altitude. The method includes receiving a first signal in a first band via a first receive antenna, and receiving a second signal in a second band via a second receive antenna. The first band is a C-Band and the second band is at least one of a W-Band, Ku-Band, Ka-Band, V-band, or K-Band. The method also includes providing an altitude in response to the first signal or the second signal.

Abstract: A temperature-robust polymer shroud for a roller bearing seal includes a shroud body and an inner diameter leg defining respective portions of a single continuous part. The shroud body encircles a rotation axis of the polymer shroud and extends predominantly in directions orthogonal to the rotation axis from an inner diameter to an outer diameter. The inner diameter leg connects to the shroud body at the inner diameter and encircles the rotation axis, wherein, along the entire inner diameter of the shroud body, the inner diameter leg is oriented at an oblique angle to the rotation axis to extend both (a) radially inward from the inner diameter and (b) axially away from the inner diameter along a first direction parallel to the rotation axis. A roller bearing seal includes a seal case, an elastomer lip, and the temperature-robust polymer shroud.

Abstract: A temperature-robust polymer shroud for a roller bearing seal includes a shroud body and an inner diameter leg defining respective portions of a single continuous part. The shroud body encircles a rotation axis of the polymer shroud and extends predominantly in directions orthogonal to the rotation axis from an inner diameter to an outer diameter. The inner diameter leg connects to the shroud body at the inner diameter, encircles the rotation axis, and is oriented at an oblique angle to the rotation axis to extend both (a) radially inward from the inner diameter and (b) axially away from the inner diameter along a first direction parallel to the rotation axis. A roller bearing seal includes a seal case, an elastomer lip, and the temperature-robust polymer shroud.