Abstract: An ion implantation system including an ion source for generating an ion beam, an end station containing a platen for supporting a substrate to be implanted by the ion beam, and a load lock disposed adjacent the end station and adapted to transfer substrates between an external environment and the end station. The load lock may include a transfer chamber having a hollow interior, a first isolation door affixed to a first side of the transfer chamber and openable to the external environment, a second isolation door affixed to a second side of the transfer chamber and openable to an interior of the end station, and a volume filling cassette disposed within the hollow interior of the transfer chamber and adapted to hold at least one substrate.

Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: A plunger lift lubricator having an internal bypass configuration which enables a plunger to be reliably captured and while still allowing the flow of fluid up through the lubricator before the fluid is directed radially outward and down the internal bypass passageways. The lubricator can comprise both an upper flow path and a lower flow path and can be configured such that a plunger can travel all the way up to shift a valve in the plunger if needed.

Abstract: A method is disclosed for using an artificial intelligence engine to modify resistance of one or more pedals of an exercise device. The method includes generating, by the artificial intelligence engine, a machine learning model trained to receive one or more measurements as input, and outputting, based on the one or more measurements, a control instruction that causes the exercise device to modify the resistance of the one or more pedals. The method includes receiving the one or more measurements from a sensor associated with the one or more pedals of the exercise device, determining whether the one or more measurements satisfy a trigger condition, and responsive to determining that the one or more measurements satisfy the trigger condition, transmitting the control instruction to the exercise device.

Abstract: A method is disclosed for using an artificial intelligence engine to modify resistance of pedals of an exercise device. The method includes generating, by the artificial intelligence engine, a machine learning model trained to receive measurements as input, and outputting, based on the measurements, a control instruction that causes the exercise device to modify, independently from each other, the resistance of the pedals. While a user performs an exercise using the exercise device, the method includes receiving the measurements from sensors associated with the pedals. The method includes determining, based on the measurements, a quantifiable or qualitative modification to the resistance provided by a pedal of the pedals. The resistance provided by another pedal of the pedals is not modified. The method includes transmitting the control instruction to the exercise device to cause the resistance provided by the pedal to be modified.

Abstract: A system and method for improving completion of an exercise is disclosed herein. In one embodiment, a method of a control system to improve compliance with an exercise plan for an exercise machine includes receiving one or more load measurements from one or more load cells of the exercise machine. The method also includes comparing the one or more load measurements to one or more target thresholds, and determining whether the one or more load measurements exceed the one or more target thresholds. Responsive to determining that the one or more load measurements exceed the one or more target thresholds, the method also includes causing a user interface to present an indication that the one or more target thresholds have been exceeded and an exercise is complete, wherein the exercise is included in the exercise plan.

Abstract: An electronic system for a drug delivery device is provided, the electronic system comprising at least one user interface member configured to be manipulated by a user for performing a dose operation, e.g.

Abstract: A ride vehicle includes a riding assembly configured to carry a rider, a base configured to couple to the riding assembly, and a control system configured to control the coordination of movements of the ride vehicle with movements of separate ride vehicles. The base includes a surface movement system configured to move the ride vehicle along a surface, a vertical movement system configured to move the riding assembly vertically relative to the base, and a roll system configured to move the riding assembly angularly relative to the base.

Abstract: Systems and methods are disclosed including a memory device and a processing device operatively coupled to the memory device. The processing device can perform operations including periodically, at a predefined frequency, incrementing a value stored in an accumulator by a composite parameter value; responsive to receiving a program request specifying a data item to be programmed to a management unit of the memory device, obtaining a first value from the accumulator; storing the first value to a program reference table; programming the data item to the management unit; responsive to receiving a read request specifying the management unit, obtaining a second value from the accumulator; determining a read voltage value based on a difference of the first value and the second value; and performing a read operation, using the read voltage value, on the management unit.

Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.

Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: This application describes the creation of a wheel disc for a trailer using a three-hit manufacturing process.

Abstract: A temperature-robust polymer shroud for a roller bearing seal includes a shroud body and an inner diameter leg defining respective portions of a single continuous part. The shroud body encircles a rotation axis of the polymer shroud and extends predominantly in directions orthogonal to the rotation axis from an inner diameter to an outer diameter. The inner diameter leg connects to the shroud body at the inner diameter and encircles the rotation axis, wherein, along the entire inner diameter of the shroud body, the inner diameter leg is oriented at an oblique angle to the rotation axis to extend both (a) radially inward from the inner diameter and (b) axially away from the inner diameter along a first direction parallel to the rotation axis. A roller bearing seal includes a seal case, an elastomer lip, and the temperature-robust polymer shroud.

Abstract: In accordance with one aspect of the present disclosure, a wear ring assembly is provided for a railway roller bearing. The wear ring assembly includes a wear ring having a central opening for receiving a journal of a railway wheel assembly and an insert including a plurality of spacers configured to extend in the opening of the wear ring to separate the wear ring from the journal. The spacers are spaced apart from each other about the wear ring. The insert may include one or more flanges that separate the wear ring from a bearing cone.

Abstract: Hip implant systems described herein can include a distal stem, a proximal body, and a fastener. In some embodiments, the distal stem can include a cavity configured to receive the fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, the distal stem can include a threaded exterior surface configured to mate with a fastener when a portion of the distal stem is positioned within the proximal body. In some embodiments, a distal end of the distal stem can include an anterior relief configured to conform to interior surface of a femoral canal of a patient.

Abstract: Disclosed are methods, kits and cells for screening for test compounds that are capable of inhibiting DNA-binding activity of a DNA-binding protein. The disclosed methods, kits and cells may include a reporter expression cassette that encodes a reporter expression product, wherein the reporter expression cassette comprises at least one binding site for the DNA-binding protein such that binding of the DNA-binding protein to the binding site inhibits expression of the reporter expression product. Also disclosed are methods for producing a helix-constrained peptide that may be used in the screening methods disclosed herein. The methods, kits and cells find application, for example, in the identification of antagonists that may be useful in the treatment of cancers involving the DNA-binding protein.

Abstract: Presented herein is an online marketplace for the selling and delivering of items for sale. The online marketplace includes devices and systems as well as their methods of use for the online purchase of goods as well as for the efficient and expedient delivery of the goods purchased. In particular embodiments, the system may include a cloud based database that stores images of the items for purchase, and may further include an associated computing device that is configured for receiving data corresponding with the one or more physical items represented by the images of the goods for sale that are stored in the database. The computing device is further configured for displaying the data corresponding with the one or more physical items for sale, e.g.

Abstract: In accordance with one aspect of the present disclosure, a wear ring assembly is provided for a railway roller bearing. The wear ring assembly includes a wear ring having a central opening for receiving a journal of a railway wheel assembly and an insert including a plurality of spacers configured to extend in the opening of the wear ring to separate the wear ring from the journal. The spacers are spaced apart from each other about the wear ring. The insert may include one or more flanges that separate the wear ring from a bearing cone.

Abstract: An intramedullary based & omni-positionable cutting guide instrumentation for femoral epiphysis resection for knee prosthesis placement comprising: an intramedullary placement guide (1,27) in a medullary cavity of a femoral epiphysis having an anterior/posterior adjustment mechanism (33); posterior rotational referencing sizing jig (8) for fastening to the anterior/posterior adjustment mechanism (33) and configured for referencing anterior (10) and posterior (11, 18) surfaces of the femoral epiphysis to adjust the anterior/posterior offset of the anterior/posterior adjustment mechanism (33); and a punch card (20) for subsequent fastening to the anterior/posterior adjustment mechanism (33) and comprising a plurality of position referencing apertures (21a-21d) for receipt of at least one locking pin (23) of a cutting block guide (5) to allow the anterior/posterior positioning of the cutting block guide (5) at a first position (e.g. FIG. 10) for making a first resection (e.g. 24) and at a second position (e.

Abstract: Presented herein is an online marketplace for the selling and delivering of items for sale. The online marketplace includes devices and systems as well as their methods of use for the online purchase of goods as well as for the efficient and expedient delivery of the goods purchased. In particular embodiments, the system may include a cloud based database that stores images of the items for purchase, and may further include an associated computing device that is configured for receiving data corresponding with the one or more physical items represented by the images of the goods for sale that are stored in the database. The computing device is further configured for displaying the data corresponding with the one or more physical items for sale, e.g.