Patents by Inventor Michael Mauragis

Michael Mauragis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20080045709
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
    Publication number: 20070027149
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 1, 2007
    Inventors: Huiping Guan, Congxin Liang, Connie Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • Process for preparing indolinone derivatives
    Publication number: 20050171357
    Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 4, 2005
    Inventors: Qingwu Jin, Michael Mauragis, Paul May
  • Salts and polymorphs of a pyrrole-substituted indolinone compound
    Publication number: 20050118255
    Abstract: The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.
    Type: Application
    Filed: September 30, 2004
    Publication date: June 2, 2005
    Inventors: Andrei Blasko, Qingwu Jin, Qun Lu, Michael Mauragis, Dian Song, Brenda Vonderwell