Abstract: A thermal conductivity detector device includes a chamber defined with an inlet channel and an outlet channel. A temperature sensing element is positioned proximal to the outlet channel and a plurality of passages is defined between the inlet channel and the outlet channel. The plurality of passages is structured to direct a fluid from the inlet channel to impinge on the temperature sensing element to detect the temperature of the fluid.

Abstract: A thermal conductivity detector device includes a chamber defined with an inlet channel and an outlet channel. The chamber is of an elliptical shape having at least two opposing sides of the chamber defined in an arcuate shape. The chamber is defined in the shape of a venturi. A temperature sensing element is positioned within the chamber. The temperature sensing element is configured to determine the temperature of a fluid flowing through the chamber from the inlet channel towards the outlet channel.

Abstract: A method for controlling a condenser unit that includes an indirect evaporative heat exchanger for pre-cooling air from ambient before the air is provided to a condenser coil includes identifying a determination that the indirect evaporative heat exchanger should be activated. The method also includes obtaining a temperature of the pre-cooled air that exits the indirect evaporative heat exchanger for cooling the condenser coil and modulating a vent that controls a portion of the pre-cooled air that is recirculated through the indirect evaporative heat exchanger through multiple wet channels such that the temperature of the pre-cooled air is maintained at least a predetermined amount above a dew point temperature.

Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.

Abstract: A method for tracking amount of refrigerant added or removed from an HVAC/refrigeration system includes fluidly coupling a service tool with an inner volume of the refrigeration system. The service tool includes a reservoir that stores and discharges a refrigerant into the refrigeration system or receives the refrigerant from the refrigeration system, and a sensing portion positioned along a fluid flow path between the reservoir and the inner volume of the refrigeration system. The method includes operating the service tool to transfer an amount of refrigerant between the inner volume of the refrigeration system and the reservoir of the service tool. The method includes obtaining a signal from a sensor of the sensing portion indicative of a flow rate of the amount of refrigerant over a time period that the refrigerant is transferred. The method includes determining the amount of refrigerant based on the signal obtained from the sensor.

Abstract: A system for predicting a leak of a HVAC/Refrigeration system includes a critically charged HVAC/Refrigeration system configured to circulate a refrigerant to cool a space, and processing circuitry. The processing circuitry is configured to obtain the subcooling data from the critically charged HVAC/Refrigeration system. The processing circuitry is configured to predict a leak event by providing the subcooling data as an input to a neural network. The neural network is trained using historical data of one or more subcooling parameters of a plurality of critically charged HVAC/Refrigeration systems. The processing circuitry is configured to operate a display to provide a notification to a technician or a manager regarding the predicted leak event at the critically charged HVAC/Refrigeration system.

Abstract: A method includes determining, based on a signal from a sensor of a service tool that couples with a service port of the HVAC/Refrigeration system to add refrigerant to the HVAC/Refrigeration system or remove refrigerant from the HVAC/Refrigeration system, an amount of refrigerant added to the HVAC/Refrigeration system or an amount of refrigerant removed from the HVAC/Refrigeration system. The method includes determining a current refrigerant level in the HVAC/Refrigeration system. The method also includes performance monitoring for a fleet of units, and predicting an indication of a leak at the HVAC/Refrigeration system. The method includes building or using a database along with artificial intelligence (AI) or machine learning (ML) to predict leaks. The method includes operating a display to provide at least one of the amount of refrigerant added, the amount or refrigerant removed, or the current refrigerant level of the HVAC/Refrigeration system to a user.

Abstract: The invention relates to Conditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: A method for producing a plurality of chips each comprising an individualisation region, each chip comprising at least: a first and a second level of the electrical tracks, and an interconnections level comprising vias. The method includes producing on the dielectric layer covering the first level a mask having openings located in line with the electrical tracks and making the dielectric layer accessible. The method includes producing, in a region of the chip comprising the individualisation region, patterns conformed so that: first openings of the hard mask are not masked by the patterns, and second openings of the hard mask are masked by the patterns. The method includes producing via openings in the dielectric layer in line solely with the first openings. The method further includes filling in the via openings with an electrically conductive material, and producing the second level of the electrical tracks on the vias.

Abstract: A method for producing an individualisation area includes providing at least a first level of the electrical tracks. The method includes depositing a dielectric layer and a deformable layer on the interconnection level. The method includes producing, in an area of the deformable layer, recessed patterns, by penetrating an imprint mould into the deformable layer, the production of the patterns being configured so that the patterns have a randomness in the deformable layer, thus forming random patterns. The method includes transferring the random patterns into the dielectric layer to form transferred random patterns therein and exposing the vias located in line with the transferred random patterns. The method includes filling the transferred random patterns with an electrically conductive material so as to form electrical connections between vias. The method includes producing a second level of the electrical tracks on the vias and the electrical connections.

Abstract: Systems and techniques may be used for providing artificial intelligence regarding orthopedic patients. A technique may include using sensor data generated over a period of time by a patient an input to a machine learning model. The machine learning model may be trained based on labeled sensor data and labeled outcome data. The machine learning model may generate a predicted outcome for the patient. The technique may include output at least one medical intervention recommendation based on the predicted outcome.

Abstract: The invention relates to a method for visualizing the automation of a drive system for a technical system, wherein the technical system consists of a plurality of modules. Module type data objects that are assigned to module types are stored in a data storage device, wherein the module type data objects include a graphical representation of the module type data relating to the particular module types. First, the module types of the modules of which the technical system is composed are selected by a user via a user interface. Module data objects assigned to the modules are generated by means of a data processing device, which module data objects contain module data, wherein the module data contain data relating to the graphical representation of the module type of each module, and wherein a data processing device generates a visualization of the assembled technical system based on the module data, which visualization is presented to the user by means of a visualization device, in particular a display.

Abstract: A method for producing an individualisation area includes providing at least a first level of the electrical tracks. The method includes depositing a dielectric layer and a deformable layer on the interconnection level. The method includes producing, in an area of the deformable layer, recessed patterns, by penetrating an imprint mould into the deformable layer, the production of the patterns being configured so that the patterns have a randomness in the deformable layer, thus forming random patterns. The method includes transferring the random patterns into the dielectric layer to form transferred random patterns therein and exposing the vias located in line with the transferred random patterns. The method includes filling the transferred random patterns with an electrically conductive material so as to form electrical connections between vias. The method includes producing a second level of the electrical tracks on the vias and the electrical connections.

Abstract: The invention relates to a method of securing an integrated circuit during its fabrication on a wafer, said method including the following steps: delimitation of said wafer of the integrated circuit (1) into a first zone called a standard zone (5a) and a second zone called a security zone (5b), and creation of a random connection tracks network (7b) in said security zone (5b) configured to interconnect a set of conducting nodes (9b) thus forming a physical unclonable function modelled by random electrical continuity that can be queried through said set of conducting nodes using a challenge-response authentication protocol.

Abstract: An integrated circuit and a method of securing the integrated circuit during its fabrication. The method includes delimitation of the integrated circuit into a first zone called a standard zone and a second zone called a security zone, and random degradation of an interconnection structure of the security zone thus forming a physical unclonable function modelled by random electrical continuity that can be queried by a challenge-response authentication protocol.

Abstract: Systems and methods for tuning and/or calibrating a charged particle beam apparatus are disclosed. According to certain embodiments, a reference specimen comprises a substrate having a plurality of first objects at a first pitch, and a plurality of second objects at a second pitch. Regions containing the first and second objects may overlap. A method of tuning and/or calibrating may comprise analyzing an image of a sample at a plurality of coarseness levels, determining whether a parameter of the image satisfies a criteria based on measured characteristics of the image at the coarseness levels, and adjusting the parameter.

Abstract: Assembling jig for mounting panel structure elements onto a surface of a CFRP-panel, comprising a base frame on which several positioning boards are transversely attached, which are parallel arranged one to another for supporting the CFRP-panel on an upper mounting surface, wherein the base frame comprises at least one metal bar for coupling the positioning boards consisting of a material having a thermal expansion coefficient which corresponds to the thermal expansion coefficient of the CFRP-material of the panel in order to provide a tolerance compensation system in at least longitudinal direction of the base frame.

Abstract: A self-guided geosteering assembly having an on-board, automated guidance system that incorporates a detailed subsurface earth model and well path to geosteer the assembly along a formation. While advancing along the formation, the guidance system continually monitors data related to formation characteristics and the formation/tool location, compares the data to the earth model and well path, and adjusts the direction of the assembly accordingly. In addition, the data may be utilized to update the earth model in real-time.