Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: Methods and compositions for altering prokaryotic cellular viability phenotypes, including antibiotic susceptibility.

Abstract: Compositions and methods for identifying and using cis-regulatory and decoy sequences are disclosed.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: Compositions and methods for identifying and using cis-regulatory and decoy sequences.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: Decoy nucleic acid sequences comprising a sequence encoding all or part of a binding site for bacterial sigN alternative sigma54 factor are described. Uses of the decoys in antibacterial complexes and for the treatment of bacterial infections are also described.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: Decoy nucleic acid sequences comprising a binding site for a target transcription factor, wherein the binding site is not operably linked to a gene, and wherein the transcription factor comprises a regulator of expression of a gene or genes in Clostridium difficile encoding one or more of: (i) a cellular growth factor; (ii) a cellular toxin; (iii) a cellular sporulation factor; (iv) a cellular stress response; and/or (v) a cellular essential gene are described. Uses of the decoys in antibacterial complexes for the treatment of bacterial infections are also described.

Abstract: Decoy nucleic acid sequences comprising a sequence encoding all or part of a binding site for bacterial sigN alternative sigma54 factor are described. Uses of the decoys in antibacterial complexes and for the treatment of bacterial infections are also described.

Abstract: The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex comprising a nucleic acid sequence and one or more delivery moieties selected from quaternary amine compounds; bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring; and an antibacterial peptide.

Abstract: Methods and compositions for altering prokaryotic cellular viability phenotypes, including antibiotic susceptibility.

Abstract: Compositions and methods for identifying and using cis-regulatory and decoy sequences.

Abstract: In a next generation packet based network a routing engine is used to determine the most cost effective route for a call from a caller/client subscriber to a call destination. The service manager or call agent softswitch, a call processor that controls the processing of calls, uses a table of softswitch node location information to determine the softswitch node in the service provider's network that is closest to the call destination. The location information related to the North American Numbering Plan (NANP) is also used to make this determination by providing the necessary location information on the call destination. The service manager the first receives the call then forwards the call through the packet backbone network of the service provider to the identified closest softswitch thereby reducing the need for use of the PSTN or another service provider's network.

Abstract: Arrays, probes and methods are disclosed for the construction and interrogation of DNA arrays containing genomic functional sites, and thereby active genetic regulatory sequences. Further methods are disclosed for interrogation of such arrays in order to reveal the pattern of genetic functional and regulatory activity within any given cell(s) or tissue type(s) or associated with any particular genetic locus or combination of loci under a variety of conditions.

Abstract: Arrays, probes and methods are disclosed for the construction and interrogation of DNA arrays containing Active Chromatin Elements, and thereby active genetic regulatory sequences. Further methods are disclosed for interrogation of such arrays in order to reveal the pattern of genetic regulatory activity within any given cell or tissue type or associated with any particular genetic locus under a variety of conditions.