Abstract: Binding members for sodium channel Nav1.7 and their use in medicine including for treatment of pain or epilepsy. Binding members comprise a fusion protein containing a Nav1.7-binding peptide, e.g., venom toxin peptide or knottin (“donor diversity scaffold domain”) inserted within an antibody variable domain (“recipient diversity scaffold domain”), and a partner domain (e.g., antibody variable domain), optionally wherein the partner domain enhances specificity of binding to Nav1.7 over other sodium channels.

Abstract: The invention relates to methods of producing eukaryotic cell libraries encoding a repertoire of binding molecules (“binders”), wherein the methods use a site-specific nuclease for targeted cleavage of cellular DNA to enhance site-specific integration of binder genes through endogenous cellular repair mechanisms. Populations of eukaryotic cells are produced in which a repertoire of genes encoding binders are integrated into a desired locus in cellular DNA (e.g., a genomic locus) allowing expression of the encoded binding molecule, thereby creating a population of cells expressing different binders.

Abstract: The invention relates to methods of producing eukaryotic cell libraries encoding a repertoire of binding molecules (“binders”), wherein the methods use a site-specific nuclease for targeted cleavage of cellular DNA to enhance site-specific integration of binder genes through endogenous cellular repair mechanisms. Populations of eukaryotic cells are produced in which a repertoire of genes encoding binders are integrated into a desired locus in cellular DNA (e.g., a genomic locus) allowing expression of the encoded binding molecule, thereby creating a population of cells expressing different binders.

Abstract: A precipitation sensor including: an outer housing having a top portion and forming the first cavity, and inside of the first cavity including a variable-permittivity medium that is exposed at a top of the first cavity; first and second conductive plates extending along at least part of a vertical dimension of the first cavity, the first conductive plate and the second conductive plate disposed so that the variable-permittivity medium separates opposing surfaces of the first conductive plate and the second conductive plate; the outer housing having a bottom portion forming a second cavity, the second cavity including means for measuring an electromagnetic characteristic of a capacitor formed by the first conductive plate, the second conductive plate, and the variable-permittivity medium.

Abstract: Embodiments of preparing substrates for subsequent bonding with semiconductor layer are described herein. A substrate may be prepared with one or more chemicals or a sacrificial layer to limit or remove substrate contaminants and reduce substrate surface damage. Other embodiments may be described and claimed.

Abstract: A system includes a transmitter, a receiver, and a processor. The processor detects a trigger event. In response to the trigger event, the transmitter transmits a detection signal. If the receiver receives a reflected detection signal, the processor determines that a door is in a first position. Additionally, if the receiver receives a reflected detection signal, the processor signals an opener to move the door to a second position.

Abstract: A set top box is provides that interfaces a television and a personal computer that is connected to the Internet. The set top box includes a wireless remote control receiver that receives user commands from a wireless remote control unit. A radio frequency transceiver that transmits computer commands to the personal computer that is connected to the internet in response to the user commands and that receives data that is generated from the Internet via the personal computer in response to the computer commands. A video processing system that processes the received data for display on a television and a television interface that displays the processed received data on the television.