Abstract: A system for mixing a fluid in a tank includes a mixer assembly, a housing, and an actuator. The mixer assembly has a motor, a shaft, and an impeller. The housing is disposed in a side wall of the tank. The housing has sufficient volume to contain the impeller. The actuator is configured to retract the mixer assembly and draw the impeller into the housing. The mixer assembly has a first conformation and a second conformation. In the first conformation the impeller is disposed in a main portion of the tank and configured to mix the fluid in response to rotation of the impeller via the motor and shaft. In the second conformation the impeller is disposed in the housing and out of the main portion of the tank.

Abstract: A system for mixing a fluid in a tank includes a mixer assembly, a housing, and an actuator. The mixer assembly has a motor, a shaft, and an impeller. The housing is disposed in a side wall of the tank. The housing has sufficient volume to contain the impeller. The actuator is configured to retract the mixer assembly and draw the impeller into the housing. The mixer assembly has a first conformation and a second conformation. In the first conformation the impeller is disposed in a main portion of the tank and configured to mix the fluid in response to rotation of the impeller via the motor and shaft. In the second conformation the impeller is disposed in the housing and out of the main portion of the tank.

Abstract: A deactivating hydraulic valve mechanism includes a hydraulic element assembly disposed within a pin housing slidably disposed within a bore in a body. A transverse bore in the pin housing contains selectively-retractable locking pins that engage a groove in the body to selectively lock together the body and the pin housing. A lost motion spring is disposed in an annular chamber between the body and the pin housing. An oil passage from an engine gallery to the hydraulic element assembly includes an axial component and bypasses the lost motion chamber. A ring holds the lifter assembly together and also sets mechanical lash. The ring may be provided as a standard-thickness ring and a shim selected to provided a predetermined amount of mechanical lash in the assembled mechanism to ensure facile engagement and disengagement of the locking pins in the body.

Abstract: A deactivating hydraulic valve mechanism includes a hydraulic element assembly disposed within cup within a pin housing slidably disposed within a bore in a body. A transverse bore in the pin housing contains selectively-retractable locking pins that engage a locking feature in the body to selectively lock together the body and the pin housing. A lost motion spring is disposed in a vented annular chamber between the body and the pin housing. An oil passage from an engine gallery to the hydraulic element assembly includes an axial component formed in the cup and bypasses the lost motion chamber. A ring holds the lifter assembly together and also sets mechanical lash. The ring may combine a standard-thickness ring and a shim selected to provided a predetermined amount of mechanical lash in the assembled mechanism to ensure facile engagement and disengagement of the locking pins in the body.

Abstract: The invention provides methods of generating small molecule efficacy profiles and signature, small molecule toxicity profiles and signatures and small molecule disease profiles and signatures. The invention also provides methods of determining the efficacy and/or toxicity of unknown agents and drugs in a subject and methods of diagnosing an unknown disease or disorder in a subject. The invention further provides methods of monitoring the progression or remission of a disease or disorder in a subject undergoing treatment and methods of measuring the effectiveness of treatment.