Abstract: Inhibitors against SARS-COV-1, SARS-CoV-2 (Covid-19), MERS-CoV, and variants within each, including methods of treating a subject suffering from such respiratory disease.

Abstract: The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: Methods, apparatus, and/or computer program products for data preprocessing are provided. The invention utilizes selective modular processes that automate data cleaning tasks and provide an initial analysis of datasets using, among other things, Natural Language Processing and Machine Learning methods. The apparatus and methods preprocess text data, clean database data with minimal human intervention, and provide automatic analytical results that include basic data cleaning, spell check, clustering, outlier detection, and natural language processing. Each modular process can be selectively switched on or off based on user input, preprogrammed instructions, or AI inputs. Additionally, any data format may be input as the apparatus and methods are data agnostic and, therefore, are not designed specifically for one type of data or theme of data. The inventive apparatus and methods dramatically reduce preparation time on the front end of data projects.

Abstract: The present invention relates to certain compounds, in particular, indole derivatives that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection.

Abstract: The present invention relates to certain compounds, in particular, indole derivatives that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection.

Abstract: In a computer-implemented method for decreasing time to deploy a virtual machine hosted by pre-configured hyper-converged computing device for supporting a virtualization infrastructure, instructions are provided to display a single end-user license agreement (EULA) to enable execution of software on the pre-configured hyper-converged computing device upon acceptance of the single EULA. Acceptance of the single EULA by a user is received. In response to the acceptance of the single EULA, a first virtual machine is deployed in a virtualization infrastructure supported by the pre-configured hyper-converged computing device such that the first virtual machine is deployed in a first time frame rather than a longer second time frame that includes accepting a plurality of EULAs.

Abstract: A compound which is a thienolate of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1, R3, Ring A1, n and Ring A2 are as defined herein, are found to be useful in inhibiting metallo-beta-lactamase and therefore in potentiating the activity of beta lactamase antibiotics. The compound can be used alone or in combination with a rhodanine of formula (II) or a pharmaceutically acceptable salt thereof: (II) wherein R3, Ring A1, n, Ring A2, L and Ring B are as defined herein. Treatment or prevention of bacterial infection in combination with beta-lactam antibiotic agents is also provided.

Abstract: A compound which is a thienolate of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1, R3, Ring A1, n and Ring A2 are as defined herein, are found to be useful in inhibiting metallo-beta-lactamase and therefore in potentiating the activity of beta lactamase antibiotics. The compound can be used alone or in combination with a rhodanine of formula (II) or a pharmaceutically acceptable salt thereof: (II) wherein R3, Ring A1, n, Ring A2, L and Ring B are as defined herein. Treatment or prevention of bacterial infection in combination with beta-lactam antibiotic agents is also provided.

Abstract: In a computer-implemented method for decreasing time to deploy a virtual machine hosted by pre-configured hyper-converged computing device for supporting a virtualization infrastructure, instructions are provided to display a single end-user license agreement (EULA) to enable execution of software on the pre-configured hyper-converged computing device upon acceptance of the single EULA. Acceptance of the single EULA by a user is received. In response to the acceptance of the single EULA, a first virtual machine is deployed in a virtualization infrastructure supported by the pre-configured hyper-converged computing device such that the first virtual machine is deployed in a first time frame rather than a longer second time frame that includes accepting a plurality of EULAs.

Abstract: In a method for decreasing time to market of a pre-configured hyper-converged computing device for supporting a virtualization infrastructure, software is developed, by a first party, to be uploaded on the pre-configured hyper-converged computing device. A second party is determined for building the pre-configured hyper-converged computing device. The first party and the second party collaborate to determine hardware efficiently suited to execute the software. The first party maintains at least some control over the second party for building the pre-configured hyper-converged computing device such that revenue is enhanced by decreasing time to market of the pre-configured hyper-converged computing device.

Abstract: In a method for decreasing user management of a pre-configured hyper-converged computing device, software updates of installed software on an underlying hardware platform of said pre-configured hyper-converged computing device are tested by a first party, wherein the installed software is provided by the first party. The software updates are provided by the first party for updating the installed software on the pre-configured hyper-converged computing device. Installation of the software updates is enabled on the pre-configured hyper-converged computing device such that user management of the pre-configured hyper-converged computing device is decreased based on the software updates previously tested on the underlying hardware platform.

Abstract: A one-way clutch includes a first race having a plurality of pockets, each pocket defining a pivot center, a second race including a plurality of notches, a plurality of rockers, each rocker being supported on a respective pocket for pivoting movement about a pivot center relative to the second race, and a spring for urging a rocker toward engagement with a notch.

Abstract: A one-way clutch includes a first race having mutually spaced pockets formed with an opening at a periphery of the first race, each pocket being at least partially bounded by a wall that extends along at least a portion of a margin of the pocket and contains a drive surface. A second race includes a series of alternating notches and cam surfaces formed on a periphery of the second race facing the openings. A plurality of rockers is located in the pockets. Each rocker includes an engagement surface for driveably engaging and disengaging a notch, a reaction surface for contacting the drive surface when the engagement surface driveably engages a notch, and guide surfaces for contacting the pocket wall to guide movement of the rocker from a disengaged position toward an engaged position. Springs, located on the first race, urge the rockers toward engagement with the cam surfaces.

Abstract: A one-way clutch includes a cam plate formed with notches, a rocker plate formed with pockets mutually spaced angularly about an axis, each pocket including an open axial end, and a surface that closes each pocket at an end opposite the open axial end of each pocket. A rocker is located in a respective pocket for movement toward and away from engagement with a notch on the cam plate. Springs are supported on the rocker plate, each spring urging a rocker toward engagement with a notch.

Abstract: A one-way clutch includes a first race having a plurality of pockets, each pocket defining a pivot center, a second race including a plurality of notches, a plurality of rockers, each rocker being supported on a respective pocket for pivoting movement about a pivot center relative to the second race, and a spring for urging a rocker toward engagement with a notch.

Abstract: A knock-down chair suitable for a child. The chair includes a rectangular seat having a slot adjacent its rear end to receive the base tongue of a back that is contoured to define a symbol such as a letter of the alphabet or a digit that identifies the chair and its occupant. Attachable to the underside of the seat adjacent each of its four corners is a leg coupling block having a cutout defining a socket to receive the head section of a respective chair leg.