Abstract: Disclosed herein are MTS peptides or targeting peptides. Disclosed are MTS peptides comprising the amino acid sequence of any one of SEQ ID NOs: 1-12. Disclosed are compositions comprising a peptide, wherein the peptide comprises a first MTS peptide conjugated to a cargo. Also disclosed are methods of using the MTS peptides. For example, disclosed are methods of transporting cargo to the CNS comprising administering one or more of the disclosed compositions to a subject in need thereof, wherein the peptide conjugated to cargo enters the CNS.

Abstract: Disclosed are MGS peptides, MTS peptides, linkers and combinations combining any combination thereof including compositions.

Abstract: Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.

Abstract: A method for synthesis of Lorazepam in a continuous flow using continuous flow reactor, in which method comprises five steps including N-acylation, diazepine ring closure, imine N-oxidation, Polonovski-type rearrangement, and ester hydrolysis; a green reagent comprising a peroxide reagent and rhenium oxide catalyst for N-oxidation of delorazepam; and an ammonium source combination for the synthesis of delorazepam.

Abstract: Disclosed are molecular guidance system (MGS) peptides and compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. An example molecular guidance system (MGS) peptide is selected from the group consisting of TGGETSGIKKAPYASTTRNR (SEQ ID NO: 60), SHHGVAGVDLGGGADFKSIA (SEQ ID NO: 61), SNSPLGLKDEATQRLVLEQAKWLA (SEQ ID NO: 62), SGETGSNLVGHELDFRPGSPSP (SEQ ID NO: 64), and CH3CO-FHAVPQSFYT-PEG11-C-NH2 (SEQ ID NO: 76).

Abstract: Disclosed are MGS peptides, MTS peptides, linkers and combinations combining any combination thereof. Disclosed are MGS peptides comprising the amino acid sequence of any of the sequences set forth in SEQ ID NOs: 1-8 Disclosed are MTS peptides comprising the amino acid sequence of any of the sequences set forth in SEQ ID NOS: 9-14. Disclosed are compositions comprising at least one MGS peptide conjugated to at least one MTS peptide, wherein the MGS peptide comprises the amino acid sequence of GFHNVYPYTWGGFSDIDLMADEI (SEQ ID NO: 1); EQRWVQMLHILQTRYAGEWPG (SEQ ID NO: 2); FQHINPFPYTYSMEDTDVEIK (SEQ ID NO: 3); or YAAWPASGAWT (SEQ ID NO: 4). In some aspects, the disclosed compositions can further comprise one or more linkers.

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

Abstract: An electronic shelf label (ESL) system is discussed. An ESL affixed to a shelf facing assists stock associates in managing products on the shelf. More particularly, the ESL may receive and display step-by-step instructions and/or graphical depictions on a display screen of the ESL that are received from a computing device-executed optimization module. The instructions may be generated to minimize the number of required actions by the stock associate and guide the associate in arranging products on the shelf. The displayed instructions may be determined based on a planogram. The planogram may be generated from a range of criteria including historical profit and loss data, inventory data, supply and demand data and/or labor cost data.

Abstract: Systems and methods for providing various Human Resources (HR) services to a company are provided. A method, according to one implementation, includes the step of monitoring employment policies and updates thereto, the employment policies representing employment laws, rules, and/or regulations applicable to each of a plurality of jurisdictions (e.g., countries, states, provinces, etc.). The method also includes the step of displaying multiple options and fields on one or more screens of a User Interface (UI) of a remote user device allowing a user to enter information defining a job to be executed by a job candidate or new employee. Also, the method includes the step of detecting whether the information entered by the user complies with the employment policies.

Abstract: Disclosed are MGS peptides, MTS peptides, linkers and combinations combining any combination thereof. Disclosed are MGS peptides comprising the amino acid sequence of any of the sequences set forth in SEQ ID NOs: 1-8 Disclosed are MTS peptides comprising the amino acid sequence of any of the sequences set forth in SEQ ID NOS: 9-14. Disclosed are compositions comprising at least one MGS peptide conjugated to at least one MTS peptide, wherein the MGS peptide comprises the amino acid sequence of GFHNVYPYTWGGFSDIDLMADEI (SEQ ID NO: 1); EQRWVQMLHILQTRYAGEWPG (SEQ ID NO: 2); FQHINPFPYTYSMEDTDVEIK (SEQ ID NO: 3); or YAAWPASGAWT (SEQ ID NO: 4). In some aspects, the disclosed compositions can further comprise one or more linkers.

Abstract: A method, non-transitory computer readable medium, and system that manage agricultural analysis in dynamic environments includes detecting a location of one or more agricultural objects of interest in image data of an environment captured by a sensor device during active navigation of the environment. An orientation and position of the sensor device with respect to the image data is determined. Each of the one or more agricultural objects of interest is analyzed based on the image data, the detected location of the one or more agricultural objects of interest, and the determined orientation and position of the sensor device to determine one or more characteristics about the one or more agricultural objects of interest. At least one action is initiated based on the determined one or more characteristics about the one or more agricultural objects of interest.

Abstract: Various examples are directed to apparatus and methods for enhancing an X-ray medical image. In one example, a method for X-ray dental images enhancement is provided. The method includes receiving an input image and applying the noise reduction trough Recursive Locally-Adaptive Wiener Filtration (RLA-WF) based on the sliding window, which is calculated following a recursive two-dimensional scheme; contrast enhancement to the filtered image, including using recursive Sliding Window Contrast Limited Adaptive Histogram Equalization (SW-CLAHE) utilizing a Truncation Threshold Surface (TTS) for calculation of the truncation threshold for the local histogram in each sliding window. The method also includes applying sharpness enhancement to the input image, including using Fast Recursive Adaptive Unsharp Masking (FRA-UM) utilizing a sliding window with two or one-dimensional recursion, to obtain a sharpened image.

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

Abstract: Various examples are directed to apparatus and methods for enhancing an X-ray medical image. In one example, a method for X-ray dental images enhancement is provided. The method includes receiving an input image and applying the noise reduction trough Recursive Locally-Adaptive Wiener Filtration (RLA-WF) based on the sliding window, which is calculated following a recursive two-dimensional scheme; contrast enhancement to the filtered image, including using recursive Sliding Window Contrast Limited Adaptive Histogram Equalization (SW-CLAHE) utilizing a Truncation Threshold Surface (TTS) for calculation of the truncation threshold for the local histogram in each sliding window. The method also includes applying sharpness enhancement to the input image, including using Fast Recursive Adaptive Unsharp Masking (FRA-UM) utilizing a sliding window with two or one-dimensional recursion, to obtain a sharpened image.

Abstract: An electronic shelf label (ESL) system is discussed. An ESL affixed to a shelf facing assists stock associates in managing products on the shelf. More particularly, the ESL may receive and display step-by-step instructions and/or graphical depictions on a display screen of the ESL that are received from a computing device-executed optimization module. The instructions may be generated to minimize the number of required actions by the stock associate and guide the associate in arranging products on the shelf. The displayed instructions may be determined based on a planogram. The planogram may be generated from a range of criteria including historical profit and loss data, inventory data, supply and demand data and/or labor cost data.

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

Abstract: A method, non-transitory computer readable medium, and system that manage agricultural analysis in dynamic environments includes detecting a location of one or more agricultural objects of interest in image data of an environment captured by a sensor device during active navigation of the environment. An orientation and position of the sensor device with respect to the image data is determined. Each of the one or more agricultural objects of interest is analyzed based on the image data, the detected location of the one or more agricultural objects of interest, and the determined orientation and position of the sensor device to determine one or more characteristics about the one or more agricultural objects of interest. At least one action is initiated based on the determined one or more characteristics about the one or more agricultural objects of interest.

Abstract: An electronic shelf label (ESL) system is discussed. An ESL affixed to a shelf facing assists stock associates in managing products on the shelf. More particularly, the ESL may receive and display step-by-step instructions and/or graphical depictions on a display screen of the ESL that are received from a computing device-executed optimization module. The instructions may be generated to minimize the number of required actions by the stock associate and guide the associate in arranging products on the shelf. The displayed instructions may be determined based on a planogram. The planogram may be generated from a range of criteria including historical profit and loss data, inventory data, supply and demand data and/or labor cost data.

Abstract: Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.

Abstract: A method, non-transitory computer readable medium, and system that manage agricultural analysis in dynamic environments includes detecting a location of one or more agricultural objects of interest in image data of an environment captured by a sensor device during active navigation of the environment. An orientation and position of the sensor device with respect to the image data is determined. Each of the one or more agricultural objects of interest is analyzed based on the image data, the detected location of the one or more agricultural objects of interest, and the determined orientation and position of the sensor device to determine one or more characteristics about the one or more agricultural objects of interest. At least one action is initiated based on the determined one or more characteristics about the one or more agricultural objects of interest.