Abstract: Described are oligonucleotides (LAMP primers), compositions, kits, and method for loop-mediated-isothermal amplification (LAMP) and/or detection of SARS-CoV-related betacoronaviruses. The methods can be used to in diagnosing SARS-CoV-2 infection.

Abstract: Use of pharmaceutical compositions comprising Bruton's tyrosine kinase (BTK) inhibitors in decreasing Epstein-Barr Virus lytic cycle or switch from latency to lytic cycle are described. The pharmaceutical compositions can be used to prevent or reduce the risk of developing an EBV-positive lymphoproliferative disease (LPD). EBV-associated malignancy, or pre-malignancy, including in immunosuppressed subjects.

Abstract: Described are oligonucleotides (LAMP primers), compositions, kits, and method for loop-mediated-isothermal amplification (LAMP) and/or detection of SARS-CoV-related betacoronaviruses. The methods can be used to in diagnosing SARS-CoV-2 infection.

Abstract: STAT3 (Signal Transducer and Activator of Transcription), which is overactive in two-thirds of human cancers, is shown herein to inhibit HR repair. This newly identified linkage of STAT3 to HR impairment forecasts that many more cancers, beyond just breast and ovarian cancers, are likely to be susceptible to PARP inhibitors and other synthetic lethal therapies. Also disclosed herein is a gene signature that can predict which cancers are likely to respond to therapy with PARP inhibitors and other synthetic lethal therapies.

Abstract: Described are methods for generating human antibodies capable of blocking one or more functions of coronavirus viroporins. The methods can be used to generate therapeutic antibodies to treat or prevent coronavirus infection, including SARS-CoV-2 infection.

Abstract: The present invention relates to wedge coupler lug brackets for attachment to an implement to permit connection of a wedge coupler on the work arm of a primary mover such as a back hoe, excavator or loader. The wedge hook brackets comprising a pair of lugs each lug having a rear facing hook section, a saddle section, the rear facing hook section and saddle section configured and adapted to accommodate bosses on the wedge coupler on the work arm that transfer the digging force from a powerlink of the primary mover to the attachment and wedge bar receiver sections to receive a wedge bar on the wedge coupler. The wedge bar receiver section is configured and adapted, in combination with the rear facing hook section, to retain the attachment to the wedge coupler by engagement with both lugs across the width of the pair of wedge coupler lug brackets mounted on the attachment.

Abstract: A sending entity creates a structured document and communicates it to a receiving entity includes a transform to ensure document elements are not moved during communication. The structured document comprises a root element and a set of child elements. A child element is protected by a digital signature, prior to being positioned within the document. This element includes a sending entity security policy. The receiving entity includes a transform that determines whether the signed element is in a given position within the received document. The transform evaluates the data string against a set of ancestor elements of the signed element to determine whether the signed element is in the given position. If so, the transform preferably outputs the signed element itself. If the transform determines that the signed element has been moved, however, preferably it outputs a given value other than the signed element.

Abstract: Methods, systems, and products are disclosed in which generating evidence of web services transactions are provided generally by receiving in an ultimate recipient web service from an initial sender a request, the request containing a proof of message origin (‘PMO’). The PMO contains an element addressed to the ultimate recipient web service and the element bears a first signature, the first signature having a value. Embodiments also include authenticating the identity of the initial sender; creating a proof of message receipt (‘PMR’) including signing the value of the first signature; sending the PMR to the initial sender, receiving, by the initial sender, the PMR; and saving, by the initial sender, the PMR.

Abstract: A process and a system that create and encrypt rich formatted passwords that increase password strength and security in some embodiments are disclosed. The process increases password security by converting a set of password tokens and a set of password appearance alterations into a rich formatted password and then encrypting the rich formatted password. The system of some embodiments includes (i) a data converter for assembling a rich formatted password from a data object comprising a set of password tokens and a set of password appearance alterations received at a password creation user interface (UI) of a computing device and (ii) a data encrypter for encrypting rich formatted passwords and decrypting encrypted rich formatted passwords, and (iii) a database for storing and retrieving encrypted rich formatted passwords.

Abstract: A method for single sign-on with established federation includes triggering a single sign-on operation from a first service to a second service, retrieving, by the first service, an associated federation key and pseudo identification for a user agent, generating, by the first service, a token signed with a federation key for the user agent based on the pseudo identification, redirecting, by the first service, the user agent to the second service, wherein the user agent transfers the token to the second service, verifying, by the second service, the token and determining an associated identification in the second service, and returning, by the second service, a resource to the user agent.

Abstract: An online retailer may post content to a third-party web site to offer content items for sale. A user may view or preview the posted content items, and may select an item to purchase. Payment for the item may be initiated independently of any interaction of the user with a web site hosted by the online retailer. An account with the online retailer may automatically be created and credited with the purchase; alternatively, the purchase can be credited to a previously established account. The payment may be processed via an online payment processor independent of the online retailer and the third party. The item may be a digital streaming video or any other suitable type of content item. After the payment is processed, the user's computer may be authorized to permit playback through the third-party web site or on a web site hosted by the online retailer.

Abstract: A process and a system that create and encrypt rich formatted passwords that increase password strength and security in some embodiments are disclosed. The process increases password security by converting a set of password tokens and a set of password appearance alterations into a rich formatted password and then encrypting the rich formatted password. The system of some embodiments includes (i) a data converter for assembling a rich formatted password from a data object comprising a set of password tokens and a set of password appearance alterations received at a password creation user interface (UI) of a computing device and (ii) a data encrypter for encrypting rich formatted passwords and decrypting encrypted rich formatted passwords, and (iii) a database for storing and retrieving encrypted rich formatted passwords.

Abstract: A machine-implemented method for signing a JSON message begins by constructing a reference element for each data object in the JSON message. The data object is identified by a reference identifier that includes a pointer to a digest method, and a digest generated by applying the digest method to the data object. Then, a signature information element is constructed for reference elements corresponding to data objects in the message. The signature information element includes a pointer to a signature method, as well as one or more reference elements, or a canonical form of the one or more reference elements. Then, a signature element is constructed that includes the signature information element, and a signature value generated by applying the signature method to the signature information element. The signature enables a sending entity to generate a digest on a JSON message and to secure the digests using a signing key.

Abstract: A method for single sign-on with established federation includes triggering a single sign-on operation from a first service to a second service, retrieving, by the first service, an associated federation key and pseudo identification for a user agent, generating, by the first service, a token signed with a federation key for the user agent based on the pseudo identification, redirecting, by the first service, the user agent to the second service, wherein the user agent transfers the token to the second service, verifying, by the second service, the token and determining an associated identification in the second service, and returning, by the second service, a resource to the user agent.

Abstract: JSON (JavaScript Object Notation) message integrity is provided using a digital signature scheme. The digital signature scheme implements a set of processing rules for creating and representing digital signatures using a JSON signature syntax. The syntax preferably comprises a set of named elements, including a reference element, a signature information element, and a signature element. In one embodiment, a machine-implemented method for signing a JSON message begins by constructing a reference element for each data object in the JSON message to be signed. The data object is identified by a reference identifier. The reference element includes the reference identifier, a pointer (such as a URI) to a digest method, and a digest generated by applying the digest method to the data object or a given function of the data object. Then, a signature information element is constructed for one or more of the reference elements corresponding to the one or more data objects in the message that are being signed.

Abstract: A method, system and computer program product for handling identity data from heterogeneous sources utilizes an Identity Data Model Broker (IDMB). The IDMB maps fields between heterogeneous data sources, served by disparate Identity Attribute Service (IdAS) context providers, to establish a normalized data format. Within an IdAS, an abstract data model, which is brokered the IDMB, is created to present a normalized view of the data from the IDMB. When a request for data is received at the IdAS, the requested data is retrieved from appropriate data sources, through respective IdAS context providers, normalized to the abstract data model, and provided to the requester by the IdAS, such that the heterogeneous data sources are shielded from the requester.

Abstract: Provided are a system and program for allowing communication among nodes in a system. A request is received in a source node from a source object executing in the source node to send a message to a destination object executing in a destination node. Each node includes a processor capable of multitasking multiple program objects and a communication interface to transmit and receive data with the other nodes. A determination is made in the source node as to whether the destination node and source node are a same node. The message is sent in the source node to the destination object within the source node if the destination node is the source node. If the destination node is not the source node, then the source node transmits the message to the destination node through the communication interface. The destination node sends the message to the destination object within the destination node.

Abstract: Provided are a system and article of manufacture for allowing communication among nodes in a system. A request is received in a source node from a source object executing in the source node to send a message to a destination object executing in a destination node. Each node includes a processor capable of multitasking multiple program objects and a communication interface to transmit and receive data with the other nodes. A determination is made in the source node as to whether the destination node and source node are a same node. The message is sent in the source node to the destination object within the source node if the destination node is the source node. If the destination node is not the source node, then the source node transmits the message to the destination node through the communication interface. The destination node sends the message to the destination object within the destination node.

Abstract: A cartridge storage device for a data storage and retrieval system according to one embodiment comprises a housing having a front and a back positioned on opposite ends of the housing; a plurality of cells in the housing, each cell adapted for receiving a media cartridge, and a drive mechanism for selectively driving the cells towards a front opening in the front of the housing, the front opening allowing insertion and retrieval of the cartridges from the cells.

Abstract: In an automated library, data cartridges, such as magnetic tape cartridges, are stored in storage cells and accessed by data storage drives. An accessor with a gripper transports cartridges between storage cells and storage drives. Cartridges are prioritized according to their relative importance. A processor manages the placement of the cartridges in cells by having higher priority cartridges stored closer to the front of multi-cartridge cells than cartridges with a lower priority. Cartridges with a higher priority may also be stored closer to a storage drive than cartridges with a lower priority. A pusher may be used to push cartridges towards the front of multi-cartridge cells with an empty position to enable the gripper to reach the front cartridge.