Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: An apparatus, system and method for providing an o-ring gripper. The embodiments may include an end effector, comprising: a housing; a movable stripping bar mechanically associated with the housing; a plurality of modules at least partially within the housing; and at least two interleaved angular jaws, wherein each of the at least two jaws provides at least two of the at least four fingers, and wherein an increase in angle between the at least two jaws effects an expansion of an area bounded by each of the at least four fingers; wherein a movement of the stripper bar distally from the housing strips the o-ring from the retention groove for placement.

Abstract: A lamination apparatus, system, and method. The apparatus, system and method are for a lamination press for laminating at least one laminating film to a subject, which may include: an upper press comprising a gel plate, an upper vacuum chamber, and tooling suitable to apply the laminating film; a lower press suitable to maintain the subject to receive the laminating film, and comprising a lower vacuum chamber, an air bearing stage, and servo-positioned tooling; and an aligner that applies the servo-positioned tooling to maintain positional balance and alignment of the subject by the air bearing stage during the laminating while enabling vertical flexure of the lower press, wherein the positional balance and alignment is substantially continuously monitored by a controller.

Abstract: An apparatus, system and method for providing a variable swath end effector. The variable swath end effector may include: two arms, each for retaining a portion of a retained element; two pairs of bearing rails, each pair being uniquely mechanically associated with a one of the two arms, wherein a level of one pair of bearing rails is staggered from a second level of the other pair of earing rails in a perpendicular axis, and wherein the staggered pairs of bearing rails are interleaved with each other; and a motor capable of driving a belt in mechanical association with each of the two arms, wherein actuation of the motor drives the belt to synchronously move each of the two arms across a respective one of the pairs of bearing rails to vary the swath between the two arms.

Abstract: A lamination apparatus, system, and method. The apparatus, system and method are for a lamination press for laminating at least one laminating film to a subject, which may include: an upper press comprising a gel plate, an upper vacuum chamber, and tooling suitable to apply the laminating film; a lower press suitable to maintain the subject to receive the laminating film, and comprising a lower vacuum chamber, an air bearing stage, and servo-positioned tooling; and an aligner that applies the servo-positioned tooling to maintain positional balance and alignment of the subject by the air bearing stage during the laminating while enabling vertical flexure of the lower press, wherein the positional balance and alignment is substantially continuously monitored by a controller.

Abstract: The disclosure provides an apparatus, system and method for a moveable bearing stage that allows for highly refined alignment and placement, and particularly planar alignment and placement, of component or devices through the use of robotics.

Abstract: The disclosure provides an apparatus, system and method for a moveable bearing stage that allows for highly refined alignment and placement, and particularly planar alignment and placement, of component or devices through the use of robotics.

Abstract: The disclosure provides an apparatus, system and method for a moveable bearing stage that allows for highly refined alignment and placement, and particularly planar alignment and placement, of component or devices through the use of robotics.

Abstract: A lamination apparatus, system, and method. The apparatus, system and method are for a lamination press for laminating at least one laminating film to a subject, which may include: an upper press comprising a gel plate, an upper vacuum chamber, and tooling suitable to apply the laminating film; a lower press suitable to maintain the subject to receive the laminating film, and comprising a lower vacuum chamber, an air bearing stage, and servo-positioned tooling; and an aligner that applies the servo-positioned tooling to maintain positional balance and alignment of the subject by the air bearing stage during the laminating while enabling vertical flexure of the lower press, wherein the positional balance and alignment is substantially continuously monitored by a controller.

Abstract: The disclosure provides an apparatus, system and method for a moveable bearing stage that allows for highly refined alignment and placement, and particularly planar alignment and placement, of component or devices through the use of robotics.

Abstract: The invention is a support device for lifting and transporting a patient or other type of load. The support device has a frame mounted on a support base equipped with wheels and a brake. Long handles are attached to the frame, to provide a significant mechanical advantage to an operator. Lifting the handles tilts the frame on the support base and brings it down close to the load to be lifted. A lifting support, such as a seat or a sling, is secured around the load and the lifting support coupled to the frame. The operator moves the lifting handles back to a home position, thereby lifting the load. The lifting handles and wheels allow the operator to guide the support device to a desired location, to lower a patient to a chair or a bed or to move a load to a new location.

Abstract: The invention is a support device for lifting and transporting a patient or other type of load. The support device has a frame mounted on a support base equipped with wheels and a brake. Long handles are attached to the frame, to provide a significant mechanical advantage to an operator. Lifting the handles tilts the frame on the support base and brings it down close to the load to be lifted. A lifting support, such as a seat or a sling, is secured around the the load and the lifting support coupled to the frame. The operator moves the lifting handles back to a home position, thereby lifting the load. The lifting handles and wheels allow the operator to guide the support device to a desired location, to lower a patient to a chair or a bed or to move a load to a new location.

Abstract: An apparatus and method allow receivers to quickly acquire a pseudorandom noise signal. A receiver advantageously detects frequency shifts using a compact parallel process hardware implementation of a Discrete Fourier Transform (DFT). The simultaneous detection of multiple frequencies allows the receiver to search the frequency range of the transmitted signal in larger increments of frequency, thereby increasing the speed of acquisition. One receiver does not use coherent integration before computation of the transform and advantageously maintains a flat frequency response. The flat frequency response of the DFT circuit enables searching of multiple frequency offsets without CPU intensive processing to compensate for frequency response variations. A receiver can include a Doppler correction circuit, which permits correlation data with frequency shift in the code to be non-coherently integrated among relatively fewer addresses or tap positions in memory.

Abstract: This invention provides a winding machine comprising a support drum, a winding tube at least partially supported on the support drum, and a web of material being wound around the winding tube to form a web reel in response to rotation of the support drum and the web reel, the point where the web reel rotates into contact with the support drum being called the nip. The winding machine further includes a nip safety guard comprising a finger presence sensor, a support mechanism supporting the finger presence sensor adjacent one of the web reel and the support drum, and a moving mechanism that moves and locates the finger presence sensor support mechanism depending on the size of the web reel so that the finger presence sensor is located closely adjacent the one of the web reel and the support drum and spaced a safe distance from the nip. The safety guard moving mechanism further includes a control for determining the size of the web reel and operating the moving mechanism to position the finger sensor.

Abstract: This invention provides a winding machine comprising a support drum, a winding tube at least partially supported on the support drum, and a web of material being wound around the winding tube to form a web reel in response to rotation of the support drum and the web reel, the point where the web reel rotates into contact with the support drum being called the nip. The winding machine further includes a nip safety guard comprising a finger presence sensor, a support mechanism supporting the finger presence sensor adjacent one of the web reel and the support drum, and a moving mechanism that moves and locates the finger presence sensor support mechanism depending on the size of the web reel so that the finger presence sensor is located closely adjacent the one of the web reel and the support drum and spaced a safe distance from the nip. The safety guard moving mechanism further includes a control for determining the size of the web reel and operating the moving mechanism to position the finger sensor.

Abstract: A dressing-aid-and-transfer device for assisting attendants and patients in moving and dressing. The device includes a space frame with support legs of the space frame defining a device perimeter. A chest support is provided to support the weight of the patient being moved. The space frame is designed so as to provide a stable and lightweight transferral device that is transportable and easy for a single person to operate. The support legs and reinforcing cross-pieces are configured to provide structurally stability without interfering with an attendant's ability to easily remove and place clothing on a patient's lower body. The support legs pivot at the base of the space frame in order to reduce the force required to transfer a patient to and from a sitting position. Optional features include a rotatable base and the use of actuators to reduce the effort required to tilt the space frame.