Abstract: In accordance with an embodiment, described herein is a system and method for connection concentration in a database environment. A transparency engine provided between client applications and a database can include a connection pool (e.g., UCP connection pool). The transparency engine can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize features provided by the connection pool without code changes. The transparency engine can receive application connections from the client applications, and concentrate the application connections on a smaller number of database connections maintained in the connection pool.

Abstract: A resuscitator has a patient airway interface device, a bag, a fluid passage coupled between the bag and patient airway interface device, and a sensor module. The patient airway interface device may be a mask or an endotracheal tube. The sensor module can have a display, at least one sensor coupled to the flow passage and configured to provide a measurement of at least one parameter, and a processor coupled to the display and the at least one sensor. The processor is configured to receive the measurement from the sensor and provide information on the display based on the received measurement. The information may include a current breath rate, a pressure-vs-time curve, and guidance to the user to assist in achieving a target breath rate.

Abstract: Disclosed is a compliance database and management system for auditing, assessing, and tracking the compliance of companies and their suppliers and method for performing the same. A method for performing supply chain compliance includes collecting supply chain data, such as information about one or more suppliers, compiling (e.g., building) the supply chain data (e.g., into a database) and providing the compiled supply chain data so that the data is accessible to a user. The compiled supply chain data can be analyzed, filtered by one or more parameters, organized by one or more parameters, or a combination thereof by a user.

Abstract: In accordance with an embodiment, described herein is a system and method for connection concentration in a database environment. A transparency engine provided between client applications and a database can include a connection pool (e.g., UCP connection pool). The transparency engine can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize features provided by the connection pool without code changes. The transparency engine can receive application connections from the client applications, and concentrate the application connections on a smaller number of database connections maintained in the connection pool.

Abstract: In accordance with an embodiment, described herein is a system and method for row buffering in a database environment. A transparency engine can be provided between client applications and a database, and can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize database features provided by the connection pool without code changes to the client applications. The transparency engine can maintain a plurality of local row buffers to store rows fetched from a database. The local buffers can be filled by rows pre-fetched from the database. When a client application requests rows from the database, the transparency engine can first check whether the rows exist in a local buffer. If the rows are present in the local buffer, the transparency engine sends the rows to the requesting client application, without going to the database.

Abstract: In accordance with an embodiment, described herein is a system and method for high availability and load balancing in a database environment. A transparency engine can be provided between client applications and a database, and can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize database features provided by the connection pool without code changes to the client applications. The transparency can keep track of session states, request boundaries and cursors to efficiently reuse the database connections across the client applications. The transparency engine can use the request boundaries and indicators from the database to detect safe places to drain database connections in the event of database outages.

Abstract: PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.

Abstract: The present disclosure relates to a reconstituted wafer- and/or panel-level package comprising a glass substrate having a plurality of cavities. Each cavity is configured to hold a single IC chip. The reconstituted wafer- and/or panel-level package can be used in a fan-out wafer or panel level packaging process. The glass substrate can include at least two layers having different photosensitivities with one layer being sufficiently photosensitive to be capable of being photomachined to form the cavities.

Abstract: Methods for treating Blepharitis, Meibomian Gland Dysfunction and Dry Eye Syndrome include thermal massage, thermal debridement, and thermal expression. Particular embodiments include use of handheld devices that provide the thermal therapy to tissue by contacting a surface heated with thermal energy to a patient's tissue. Thermal energy can be continuously provided during operation. In particular embodiments, a handheld device comprises a base assembly operatively connected to a removeable thermal energy applicator. A wide range of thermal applicators may be connected to the base assembly to provide different treatments, including heat application, debridement, and expression of the treated tissue or gland.

Abstract: In accordance with an embodiment, described herein is a system and method for high availability and load balancing in a database environment. A transparency engine can be provided between client applications and a database, and can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize database features provided by the connection pool without code changes to the client applications. The transparency can keep track of session states, request boundaries and cursors to efficiently reuse the database connections across the client applications. The transparency engine can use the request boundaries and indicators from the database to detect safe places to drain database connections in the event of database outages.

Abstract: Described is a system, method, and computer program product is provided that implements high-volume data ingestion in a relational database system. A middle-tier structure is provided that sits between the IoT data producers and the back-end database system. Data records are gathered together and organized at the middle tier, and groups of those records are ingested on a group-basis into the database in a manner which bypasses standard SQL engine processing.

Abstract: Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.

Abstract: An applicator assembly includes at least one ampoule formed of a frangible material and containing liquid to be applied, a body having a proximal end, a distal end, and an interior portion defining a chamber adapted to receive the at least one ampoule, an application member attached to the distal end of the body, an actuator projecting from the body operable to fracture the at least one ampoule, a trench formed in a surface of the body, and a vent disposed through a surface of the trench.

Abstract: A patient warming device with patient access for maintaining normothermia and/or treating hypothermia is provided. The device includes a first compliant layer and a second compliant layer sealed together around an outer border to contain a liquid between the two layers and to form a wrap that surrounds and conforms to a body portion of a patient. A plurality of flaps extends from opposite sides of a generally longitudinal central portion of the wrap, such that one or more flaps from the opposite sides fasten to each other to surround the body portion. The flaps are openable during functional use to provide access to an underlying patient body surface. A continuous fluid flow path extends between the first compliant layer and the second compliant layer between a fluid inlet and a fluid outlet to carry liquid and deliver heat through the wrap.

Abstract: An apparatus includes a sample holder to hold or receive a sample during use. The apparatus also includes a first chamber operably coupled to the sample holder and configured to receive the sample holder. The first chamber includes at least one extraction reagent for extracting nucleic acid from the sample during use to generate a first treated sample. The first chamber and the sample holder collectively define a common longitudinal axis. The apparatus also includes a second chamber operably coupled to the first chamber and disposed along the longitudinal axis. The second chamber includes at least one oligomer for amplifying the nucleic acid to generate a second treated sample.

Abstract: CEST MR imaging, called Multi-echo Parametric VARiation Saturation (Me-PaVARS) CEST places multiple image readouts in between a series of saturation pulses. The saturation pulse parameters are varied in a designated systematic pattern, which allows the generation of CEST contrast maps by encoding the patterns of signal loss into the images for better discrimination between various CEST imaging agents. The saturation parameter changes include, but are not limited to, saturation amplitude (B1), saturation length (tsat), number of pulses, shape of saturation pulses, amplitude of saturation pulses, saturation offset frequency, or a combination of these variations.

Abstract: In accordance with an embodiment, described herein is a system and method for connection concentration in a database environment. A transparency engine provided between client applications and a database can include a connection pool (e.g., UCP connection pool). The transparency engine can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize features provided by the connection pool without code changes. The transparency engine can receive application connections from the client applications, and concentrate the application connections on a smaller number of database connections maintained in the connection pool.

Abstract: In accordance with an embodiment, described herein is a system and method for row buffering in a database environment. A transparency engine can be provided between client applications and a database, and can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize database features provided by the connection pool without code changes to the client applications. The transparency engine can maintain a plurality of local row buffers to store rows fetched from a database. The local buffers can be filled by rows pre-fetched from the database. When a client application requests rows from the database, the transparency engine can first check whether the rows exist in a local buffer. If the rows are present in the local buffer, the transparency engine sends the rows to the requesting client application, without going to the database.

Abstract: In accordance with an embodiment, described herein is a system and method for high availability and load balancing in a database environment. A transparency engine can be provided between client applications and a database, and can operate as a proxy engine for the database and as a session abstraction layer for the client applications, to enable the client applications to utilize database features provided by the connection pool without code changes to the client applications. The transparency can keep track of session states, request boundaries and cursors to efficiently reuse the database connections across the client applications. The transparency engine can use the request boundaries and indicators from the database to detect safe places to drain database connections in the event of database outages.

Abstract: PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.