Abstract: The present disclosure provides compositions, systems, and tools for modeling the canine liver and methods of using the same. The disclosure provides micropatterned hepatocyte co-cultures where individual cell populations remain functionally stable during long-term culture.

Abstract: Systems and methods are provided for detecting subterranean properties associated with a geological domain. One example method may comprise obtaining waveform information corresponding to a geological domain. The method may further comprise performing a global inversion on the waveform information. Furthermore, the method may comprise performing a deterministic inversion on the waveform information. The method may also comprise determining one or more subterranean properties associated with the geological domain based at least in part on the global inversion and the deterministic inversion.

Abstract: Systems and methods are provided for dynamically determining a static tip resistance of a dynamically-loaded component having a tip. One example method comprises receiving gauge data from one or more gauges associated with the component proximate the tip. The gauge data may represent measurements related to one or more impacts on the component. The example method may further comprise determining measured data and estimated data corresponding to the one or more impacts on the component based at least in part on the gauge data. Furthermore, the method may comprise performing an inversion to select the estimated data having the least amount of difference in comparison to the measured data. The method may also comprise determining the static tip resistance based at least in part on the selected estimated data.

Abstract: The present disclosure provides compositions, systems, and tools for modeling the canine liver and methods of using the same. The disclosure provides micropatterned hepatocyte co-cultures where individual cell populations remain functionally stable during long-term culture.

Abstract: The present disclosure provides compositions, systems, and tools for modeling liver inflammation and methods of using the same. The disclosure provides micropatterned hepatocyte-Kupffer cell co-cultures or Kupffer cell-treated hepatocyte co-cultures where hepatocytes maintain Kupffer cell-initiated activities during long-term culture. The in vitro liver inflammation models of the present disclosure may be useful for evaluating both acute as well as chronic inflammation-mediated toxicities of compounds in a pre-clinical setting.

Abstract: Systems and methods are provided for detecting subterranean properties associated with a geological domain. One example method may comprise obtaining waveform information corresponding to a geological domain. The method may further comprise performing a global inversion on the waveform information. Furthermore, the method may comprise performing a deterministic inversion on the waveform information. The method may also comprise determining one or more subterranean properties associated with the geological domain based at least in part on the global inversion and the deterministic inversion.

Abstract: Systems and methods are provided for dynamically determining a static tip resistance of a dynamically-loaded component having a tip. One example method comprises receiving gauge data from one or more gauges associated with the component proximate the tip. The gauge data may represent measurements related to one or more impacts on the component. The example method may further comprise determining measured data and estimated data corresponding to the one or more impacts on the component based at least in part on the gauge data. Furthermore, the method may comprise performing an inversion to select the estimated data having the least amount of difference in comparison to the measured data. The method may also comprise determining the static tip resistance based at least in part on the selected estimated data.

Abstract: Systems and methods are provided for establishing and securing a foundation in a substrate. For example, in one embodiment, a pump conveys a first fluid (e.g., water) through a pile member to produce an elongate opening in a substrate, which allows the pile member to be advanced into the substrate. After the pile member has been advanced into the elongate opening in the substrate, a second fluid (e.g., fluidized concrete) is conveyed out of openings on the side (and the bottom) of the pile member to substantially secure the pile member in the elongate opening defined in the substrate.

Abstract: The present disclosure provides compositions, systems, and tools for modeling liver inflammation and methods of using the same. The disclosure provides micropatterned hepatocyte co-cultures where individual cell populations remain functionally stable during long-term culture. The in vitro liver inflammation models of the present disclosure may be useful for evaluating inflammation-mediated toxicities of compounds in a pre-clinical setting.

Abstract: Systems and methods are provided for establishing and securing a foundation in a substrate. For example, in one embodiment, a pump conveys a first fluid (e.g., water) through a pile member to produce an elongate opening in a substrate, which allows the pile member to be advanced into the substrate. After the pile member has been advanced into the elongate opening in the substrate, a second fluid (e.g., fluidized concrete) is conveyed out of openings on the side (and the bottom) of the pile member to substantially secure the pile member in the elongate opening defined in the substrate.

Abstract: According to various embodiments, devices, systems, and methods are provided for controlling a compactive effort delivered to a soil by a compaction unit. A device, according to one embodiment, includes a compaction unit (13) that delivers a compactive effort to soil, first and second sensing units (12, 14) that measure the first and second sensing data at a discrete global position at a first and second point in time, respectively, a comparing unit that compares the first and second sensing data, and a control unit (18) that modifies the compactive effort delivered to the soil by the compaction unit based on the comparison between the first and second sensing data. The discrete global position is in front of the compaction unit in the direction of travel of the compaction unit at the first point in time and is behind the compaction unit at the second point in time.

Abstract: A vehicle safety and control system provides early warning and includes a network including a plurality of remotely located modules disposed along a vehicle pathway. Each module is communicably connected to at least one of the other modules. The modules include a measurement system including at least one sensor for obtaining sensor data. The sensor data provides position and velocity data for objects proximate thereto. The modules also include an illuminated display having a plurality of observable distinct states, the observable states including states relating to the sensor data.

Abstract: A vehicle safety and control system provides early warning and includes a network including a plurality of remotely located modules disposed along a vehicle pathway. Each module is communicably connected to at least one of the other modules. The modules include a measurement system including at least one sensor for obtaining sensor data. The sensor data provides position and velocity data for objects proximate thereto. The modules also include an illuminated display having a plurality of observable distinct states, the observable states including states relating to the sensor data.

Abstract: Apparatus for estimating LED printhead junction temperature as a function of an input data stream, and for automatically compensating the printhead drive signal to maintain proper printer calibration to provide junction-level compensation for efficiency loss of an LED as the LED warms due to thermal energy generation from an electrical drive current is effected by a plurality of selectable LED temperature-specific look up tables constructed for a plurality of different LED temperatures. The selected look up table produces an output for driving the LED when the selected look up table is accessed by the input data. A model of the thermal characteristics of the LED, its heat sink, and the structure attaching the LED to the heat sink is adapted to produce an estimate of the temperature of the LED as a function of the image data. An address decoder selects one of the plurality of look up tables to process the input data stream in accordance with the estimate produced by the model.