Abstract: The invention provides novel glucocorticosteroids, glucocorticosteroid-linkers and antibody drug conjugates (ADC's) comprising an antibody or antibody fragment which binds to an antigen expressed on immune cells, optionally an antigen expressed on human immune cells. In some instances the ADCs comprise an anti-human VISTA (V-region Immunoglobulin-containing Suppressor of T cell Activation (1)) antibody or anti-VISTA antigen-binding antibody fragment which binds to VISTA expressing cells at physiologic pH having a short serum half-life (?24-72 or 24-48 or 12-24 hours or less in a human VISTA knock-in rodent or ((?1-3.5 days or less in a human or non-human primate). In some instances these ADCs have a rapid onset of action and are potent for prolonged duration as they are very effectively internalized by immune cells in large amounts where they are cleaved releasing large amounts of active steroid payload.

Abstract: The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.

Abstract: An image of a check that is in the field of view of a camera is monitored prior to the image of the check being captured. The camera is associated with a mobile device. When the image of the check in the field of view passes monitoring criteria, an image may be taken by the camera and provided from the mobile device to a financial institution. The image capture may be performed automatically as soon as the image of the check is determined to pass the monitoring criteria. The check may be deposited in a user's bank account based on the image. Any technique for sending the image to the financial institution may be used. Feedback may be provided to the user of the camera regarding the image of the check in the field of view.

Abstract: An interactive top-down emissions model, and methods of generating thereof, are disclosed. An example method comprises: receiving reference emissions reports respectively associated with an organization, a basin, or a facility. Each reference emissions report indicates reference emissions data associated with the organization, the basin, or the facility over a predefined time period. Facility information indicating ownership history and/or placement history of facilities are also received.

Abstract: The invention is related to a method for bonding components of a PEM fuel cell with a frame and/or amongst one another, wherefore an adhesive curable by electromagnetic radiation in the range of visible light or UV is applied to the frame and/or the at least one component. The invention is characterized in that the adhesive is activated by the electromagnetic radiation and heated after the frame and/or components are brought into contact; or the frame and/or the components are brought into contact and the adhesive is exposed to electromagnetic radiation for activating and heating; to reduce its viscosity before the adhesive is finally cured.

Abstract: The invention is related to a method for bonding components of a PEM fuel cell with a frame and/or amongst one another, wherefore an adhesive curable by electromagnetic radiation in the range of visible light or UV is applied to the frame and/or the at least one component. The invention is characterized in that the adhesive is activated by the electromagnetic radiation and heated after the frame and/or components are brought into contact; or the frame and/or the components are brought into contact and the adhesive is exposed to electromagnetic radiation for activating and heating; to reduce its viscosity before the adhesive is finally cured. The adhesive is a cationic epoxy which contains water.

Abstract: System and method to automatically control a track timing system for humans and/or animals. One or several users are detected in start and finish areas on one or several tracks and automatically signaled to start by the system. Results such as finish time, start reaction time, false starts, split times, relay exchanges, and such can be calculated. The results can be displayed and distributed, and the system can be configured by a user.

Abstract: A device that includes a control element that has multiple degrees of freedom; a mobile device holder that is configured to control a movement of a mobile device when the mobile device is connected to the mobile device holder; and a transmission mechanism that is configured to translate a movement of the control element to a corresponding movement of at least a part of the mobile device holder.

Abstract: Various embodiments provide a connector system including a plug body and a connector body each having one of studs and jacks with parallel misaligned axes. A deformation of one or more of a plug body, studs, jacks, and a connector body is created when plugging together the misaligned studs and jacks. The deformation creates resultant forces between the studs and jacks for electrical contact. The studs and jacks may be solid metal corrosive-resistant parts, such as titanium, Hastelloy, or Inconel.

Abstract: A stackable connector system having upper and lower members is provided. The upper member has a first set of upper connections including studs or jacks and a second set of upper connections including studs or jacks that are opposite the first set of upper connections. The lower member includes a first set of lower connections including studs or jacks that are opposite the second set of upper connections. The second set of upper connections and the first set of lower connections have parallel axes that are misaligned in an unplugged state. The misalignment creates deformation of the upper member and/or lower member during insertion of the studs into the jacks when the second set of upper connections and the first set of lower connections are plugged together. The deformation creates a resultant force between the second set of upper connections and the first set of lower connections.

Abstract: A stackable connector system having upper and lower members is provided. The upper member has a first set of upper connections including studs or jacks and a second set of upper connections including studs or jacks that are opposite the first set of upper connections. The lower member includes a first set of lower connections including studs or jacks that are opposite the second set of upper connections. The second set of upper connections and the first set of lower connections have parallel axes that are misaligned in an unplugged state. The misalignment creates deformation of the upper member and/or lower member during insertion of the studs into the jacks when the second set of upper connections and the first set of lower connections are plugged together. The deformation creates a resultant force between the second set of upper connections and the first set of lower connections.

Abstract: System and method to automatically control a track timing system for humans and/or animals. One or several users are detected in start and finish areas on one or several tracks and automatically signaled to start by the system. Results such as finish time, start reaction time, false starts, split times, relay exchanges, and such can be calculated. The results can be displayed and distributed, and the system can be configured by a user.

Abstract: Various embodiments provide a connector system including a plug body and a connector body each having one of studs and jacks with parallel misaligned axes. A deformation of one or more of a plug body, studs, jacks, and a connector body is created when plugging together the misaligned studs and jacks. The deformation creates resultant forces between the studs and jacks for electrical contact. The studs and jacks may be solid metal corrosive-resistant parts, such as titanium, Hastelloy, or Inconel.

Abstract: The dump cart liner of the present invention includes a shaped liner and a handle-strap. The liner is designed to fit into lawn, barn and utility dump carts and designed to remove dump material from the carts when the carts are in the dump position. Presently the only means to remove dump material from the carts in the dump position is by scraping the material out manually with shovel, rake or garden hoe.

Abstract: A motorcycle includes a rear brake caliper bracket coupled to the swingarm. In some constructions, the rear brake caliper bracket includes a caliper mounting portion and a license plate mounting portion. In some constructions, the rear brake caliper bracket includes an axle engaging portion secures and retains the axle relative to the swingarm in a desired position along the axis of rotation. In some constructions, the rear brake caliper bracket is disposed at a laterally outward side of the swingarm and includes a caliper mounting portion, first and second swingarm engaging portions, and an axle engaging portion. In such constructions, the motorcycle may further include an axle adjusting member engaged with the rear brake caliper bracket and operable to adjust the position of the axle relative to the swingarm.

Abstract: A steel door system is disclosed. The steel door system includes a steel door, a steel door jamb, and a steel window frame. Each component of the steel door system is made with minimal materials and joints. The minimal materials and joints greatly reduce the risk of failure of the final steel door system. The steel door is made of steel door stiles and rails that are each formed of a single piece of sheet metal. The steel door jamb is made of three pieces of sheet metal, and the steel window frame is made of three pieces of sheet metal. These components are coupled together to create the finalized steel door system.

Abstract: The inventive technology, in embodiments, includes an aquatic event timer apparatus that comprises at least two independent, touch actuated electrical switches; and a structural connector that adjacently connects them, where the apparatus is configured for establishment within lane markers defining a regulation size swim lane, at the end of the swim lane, and at least partially underwater. Other aspects of the inventive technology address an aquatic event timer apparatus that comprises a first, independent, swim competition type, touch actuated electrical switch that is configured for establishment within swim lane markers, and aside at least a second, independent, swim competition type, touch actuated electrical switch.

Abstract: A tail light assembly for a motorcycle. The tail light assembly includes a housing configured to receive a circuit. The circuit includes a light emitting diode (LED) and a controller. The LED provides tail, stop, and turn visual indications associated with the motorcycle. The controller supplies a voltage to the LED to light the LED to a brightness based on the signals received. In addition, the controller also sinks a current of a magnitude substantially equivalent to a magnitude of current drawn by an incandescent lamp when providing a visual turn indication.

Abstract: A bipolar flow field plate assembly comprising an anode plate assembly and a cathode plate assembly, each further comprising an anode flow field plate and a cathode flow field plate, respectively. The anode and cathode flow field plates each comprise an active surface and an inactive surface. The anode and cathode plate assemblies comprise an electrically-insulating frame attached to the active surfaces of the anode and cathode flow field plates around a peripheral edge thereof, and an inner frame attached to the inactive surfaces of the anode and cathode flow field plates around an opposing peripheral edge thereof. The inactive surfaces of the anode ad cathode flow field plates cooperate to form a coolant field therebetween. Methods for making the bipolar flow field plate assembly are also disclosed.

Abstract: Apparatus, systems, and methods for bonding one element of an electrochemical cell or cell stack to another wherein a sealing grove with a complex cross-sectional shape receives and retains a bead of adhesive prior to being assembled. The complex cross-sectional shape has a raised portion sized to receive and retain the bead of adhesive, and at least one depressed portion to receive adhesive displaced from the raised portion during assembly. Embodiments of the invention incorporate raised portions with straight, beveled, curved, and rough surfaces to increase the strength of the bond between the respective elements.