Patents by Inventor Michael Meldgaard

Michael Meldgaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210388359
    Abstract: The present invention relates to a method for determining the amount of an oligonucleotide present in a powdered form. The method does not require the experimental determination of the extinction coefficient of the oligonucleotide or the serial dilution and A260 measurement. The method is, for example, applicable to modified oligonucleotides including 2? sugar-modified oligonucleotides, phosphorothioate oligonucleotides, reporter labelled oligonucleotides, and conjugated oligonucleotides.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Inventors: Inna APPELDORFF LARSEN, Michael MELDGAARD
  • Publication number: 20210292357
    Abstract: The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3? oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and deprotection occurs very rapidly.
    Type: Application
    Filed: March 22, 2018
    Publication date: September 23, 2021
    Inventors: Michael Meldgaard, Marianne B. Mogensen, Dennis Jul Hansen
  • Publication number: 20210040137
    Abstract: The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.
    Type: Application
    Filed: February 28, 2020
    Publication date: February 11, 2021
    Inventors: Dennis Jul Hansen, Christoph Rosenbohm, Michael Meldgaard
  • Patent number: 10577388
    Abstract: The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 3, 2020
    Assignee: Roche Innovation Center Copenhagen A/S
    Inventors: Dennis Jul Hansen, Christoph Rosenbohm, Michael Meldgaard
  • Publication number: 20180305392
    Abstract: The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.
    Type: Application
    Filed: September 29, 2016
    Publication date: October 25, 2018
    Inventors: Dennis Jul Hansen, Christoph Rosenbohm, Michael Meldgaard
  • Publication number: 20140288299
    Abstract: The present invention relates to a process for preparing a short oligonucleotide comprising the steps of: (i) preparing a crude mixture comprising the oligonucleotide (ii) subjecting the mixture formed in step (i) to a desalting step; wherein the process does not comprise a chromatographic purification step.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 25, 2014
    Applicant: SANTARIS PHARMA A/S
    Inventors: Michael Meldgaard, Marianne Mogensen, Christian Frauendorf, Christoph Rosenbohm
  • Patent number: 7504495
    Abstract: The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucleosides, nucleotides, carbohydrates and peptides. For example, polynucleotides can be labeled at the 3? terminus with fluorescence quencher solid support compositions, and polynucleotides can be labeled at internally or at the 5? terminus. The detectable probes may have a format like molecular beacons, scorpion probes, sunrise probes, conformationally assisted probes and TaqMan probes.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: March 17, 2009
    Assignee: Exiqon A/S
    Inventors: Christian Lomholt, Henrik M. Pfundheller, Michael Meldgaard
  • Publication number: 20060014183
    Abstract: The invention relates to probes which are extendable useful as PCR probes and in probe libraries. The invention further relates to prevention of replication of a primer extension product in PCR reactions.
    Type: Application
    Filed: June 10, 2005
    Publication date: January 19, 2006
    Inventors: Henrik Pfundheller, Michael Meldgaard, Peter Mouritzen, Peter Nielsen, Mikkel Norholm, Soren Echwald
  • Publication number: 20050227254
    Abstract: The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucleosides, nucleotides, carbohydrates and peptides. For example, polynucleotides can be labeled at the 3? terminus with fluorescence quencher solid support compositions, and polynucleotides can be labeled at internally or at the 5? terminus. The detectable probes may have a format like molecular beacons, scorpion probes, sunrise probes, conformationally assisted probes and TaqMan probes.
    Type: Application
    Filed: November 19, 2004
    Publication date: October 13, 2005
    Inventors: Christian Lomholt, Henrik Pfundheller, Michael Meldgaard