Abstract: In part, the disclosure relates to an imaging system that includes a control system; image sensors in electrical communication with the control system, the one or more image sensors support data collection relative to a first pixel subwindow; and an optical assembly, the optical assembly oriented to receive light from the target and direct the light to the image sensor; wherein the optical assembly has an imaging focal volume within the imaging environment that spans a range of focus. The timing system is in electrical communication with the one or more image sensors, an illumination system and a translation assembly. A translation assembly may move target in imaging environment. The timing systems triggers illumination system to illuminate the target and the one or more sensors to image the target when image sensor pixel values in the first pixel subwindow align with at least a portion of the target.

Abstract: The invention provides a new system and method for imaging a specimen. The system projects a three-dimensional crystalline pattern of light, a tessellation, and records the specimen's emitted light at locations where a portion of the specimen coincides with the pattern.

Abstract: The invention provides an improved robotic handler for multi-well plates. The handler comprises a vertical elevator with integral mounts for instruments used in cellular experiments. This solution reduces overall mechanical complexity while reducing the working volume of previous collections of devices with similar function.

Abstract: The invention provides an novel imaging system for microscopy including both continuous motion and stationary field image acquisition. More specifically, the invention provides a system that can translate a specimen relative to the field-of-view of an imager while synchronously acquiring image data. Using the same imaging optics and imager, the system can acquire stationary images at any location on the specimen.

Abstract: The invention is a system and method for controllable alignment of any of a plurality of electro-optical components mounted to a circuit board with an optical axis. In one embodiment, the invention provides an improved illumination system for microscopy. The system incorporates a circuit board 31 providing structure and directly mounting a plurality of light emitting sources. The mounted light sources are rotatably alignable with a plurality of optical axes. The system further includes selectable conditioning of the sources.

Abstract: Improved methods and systems for imaging are provided. Specifically, systems and methods for extending the range of a digital zoom are provided in which an imaging system provides continuous magnification over a plurality of interleaved optical pathways and digital zooming imagers. Systems and methods of centering an image as the field of view changes, and for masking out undesirable obstacles from a magnified image are also provided.

Abstract: A method and apparatus for measuring motion of an object substantially orthogonal to an optical axis of an interferometer. The method includes the steps of obtaining a first interferogram and a second interferogram, wherein each of the first and second interferograms includes intensity information of each of at least two pixels, and determining the motion of the object from the first and the second interferograms in response to the difference of the intensity gradients of the pixels in the first and second interferograms in the orthogonal direction. The system includes a first interferogram including intensity information of each of at least two pixels and a second interferogram including intensity information of each of at least two pixels.

Abstract: A method and apparatus for measuring motion of an object substantially orthogonal to an optical axis of an interferometer. The method includes the steps of obtaining a first interferogram and a second interferogram, wherein each of the first and second interferograms includes intensity information of each of at least two pixels, and determining the motion of the object from the first and the second interferograms in response to the difference of the intensity gradients of the pixels in the first and second interferograms in the orthogonal direction. The system includes a first interferogram including intensity information of each of at least two pixels and a second interferogram including intensity information of each of at least two pixels.

Abstract: Microscopic motions of a target are measured by illuminating the target, receiving the image of the illuminated target, and controlling illumination with a computer. The real-time image of the illuminated target may be displayed.

Abstract: Microscopic motions of a target are measured by illuminating the target, receiving the image of the illuminated target, and controlling illumination with a computer. The real-time image of the illuminated target may be displayed.

Abstract: A synthetic aperture system for producing a non-periodic pattern in a region of overlap. The system includes a source of electromagnetic radiation producing a plurality of electromagnetic beams, a plurality of beam controllers positioned to receive a respective one of the plurality of electromagnetic beams and direct the respective electromagnetic beam into the region of overlap; and a system controller in electrical communication with each of the plurality of the beam controllers. Each beam controller controls at least one of the phase, amplitude and polarization of a respective one of the plurality of electromagnetic beams in response to control signals from the system controller. The result is a non-periodic pattern formed within the region of overlap by the interference of a plurality of electromagnetic beams in response to the control signals from the system controller. The invention also relates to a method for producing a non-periodic pattern in a region of overlap.

Abstract: A method for spatially modulating radiation includes directing at least one radiation beam upon at least one surface acoustic wave diffractive element, and driving at least one of the surface acoustic diffractive elements with a plurality of modulating signals to generate a plurality of modulated output radiation beams having parameters.

Abstract: A synthetic aperture system for producing a non-periodic pattern in a region of overlap. The system includes a source of electromagnetic radiation producing a plurality of electromagnetic beams, a plurality of beam controllers positioned to receive a respective one of the plurality of electromagnetic beams and direct the respective electromagnetic beam into the region of overlap; and a system controller in electrical communication with each of the plurality of the beam controllers. Each beam controller controls at least one of the phase, amplitude and polarization of a respective one of the plurality of electromagnetic beams in response to control signals from the system controller. The result is a non-periodic pattern formed within the region of overlap by the interference of a plurality of electromagnetic beams in response to the control signals from the system controller.The invention also relates to a method for producing a non-periodic pattern in a region of overlap.