Abstract: The invention relates to devices and methods for detecting a substance by cell surface polarizations and the detection thereof by means of PPR or particle-mediated fluorescence. The device for detecting a substance by cell surface polarization according to the invention has cells, wherein a gene the expression of which leads to the polarized presentation of a protein on the surface of the cell is placed under the control of a promotor which can be regulated by the substance to be detected, nanoparticles which are functionalized with a molecule which can bind specifically to the surface-exposed protein, and at least one optical measurement device, such that an accumulation of the nanoparticles on the surface of the cells can be detected by particle plasmon resonance or particle-mediated fluorescence.

Abstract: In a method for detection of microorganisms and/or their activity with biosensors, on a surface of a substrate over portions thereof at least one ligand for binding a receptor or at least one receptor for a ligand or at least one ligand for binding a receptor and at least one receptor for either the one or a further ligand are immobilized chemically, physically, or biologically, wherein physical or physicochemical changes, caused at receptors by binding of ligands that are emitted by microorganisms in the process of quorum sensing are measured.

Abstract: A nanostructure is provided on a substrate by forming at least one multi-electrode arrangement on the substrate, wherein said electrodes comprise respective electrode areas projected with respect to the opposite electrode ends which extend along a line in such a way that the adjacent ends produce a respectively frequency time-variable potential difference. A suspension of nano-object such as nanotubes, nanowires and/or carbon nanotubes is produced and then transferred to the substrate between the adjacent ends. The assembly of respective individual nano-objects is dielectrophoreticly deposited on the line between said adjacent ends, and the assembly of respective nano-objects is fused in the area of the ends in such a way that the nanostructure is formed.

Abstract: A substrate with spatially selective metal coating is produced by first applying biological templates onto parts of the surface of the substrate and applying a metal coating only once the biological templates have been deposited on the substrate. The biological templates are for example surface layer proteins (S-layer) and the metal coating is a noble metal coating. The substrates with spatially selective metal coating are used in catalysts or solid-state electrolyte sensors.

Abstract: The invention relates to a novel method for generating nucleation centers for the selective heterogeneous metal cluster growth on DNA molecules by employing metal complexes which are being bonded covalently to the bases of the DNA. The nucleation centers serve as preferred locations of chemical deposition of metals on the DNA from a solution so that clusters or thin metal films can be grown on the biological template without metallic deposition products being formed homogeneously in the solution. The method provides the possibility of controlling the metallization via the sequence of the employed DNA and is thus in principle sequence-specific.