Patents by Inventor Michael Midler, Jr.

Michael Midler, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallization method to improve crystal structure and size
    Patent number: 5314506
    Abstract: Impinging fluid jet streams are used in a continuous crystallization process to achieve high intensity micromixing of fluids so as to form a homogeneous composition prior to the start of nucleation. This process permits direct crystallization of high surface area particles of high purity and stability.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: May 24, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Michael Midler, Jr., Edward L. Paul, Edwin F. Whittington, Mauricio Futran, Paul D. Liu, Jaanpyng Hsu, Shih-Hsie Pan
  • Process for preparing an emulsion
    Patent number: 4073743
    Abstract: A process for preparing a highly stable water-in-oil type emulsion consisting of (a) a disperse aqueous phase; (b) a continuous oil phase containing isomannide monooleate emulsifier and a non-hydrated physiologically acceptable fatty acid metal salt. A particular use of the invention is the preparation of an emulsion adjuvant vaccine, wherein the vaccine is incorporated in the aqueous phase.The emulsion is prepared by mixing the aqueous and oil phases at a relatively low agitator speed, optionally cooling, increasing the speed of agitation to form an emulsion and optionally homogenizing the emulsion.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Michael Midler, Jr., Edward Paul
  • Crystallization system and method using crystal fracturing external to a crystallization column
    Patent number: 3996018
    Abstract: Crystals are grown in a column through which a supersaturated solution flows upwardly while large crystals having one dimension substantially greater than another dimension taken from the bottom of the column are fractured externally of the column and the fractured particles are returned to the upper end of the column where fines are separated from larger seed type particles.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: December 7, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Michael Midler, Jr.