Patents by Inventor Michael MIETZNER
Michael MIETZNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11739289Abstract: An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.Type: GrantFiled: April 21, 2020Date of Patent: August 29, 2023Assignee: Lonza LtdInventors: Michael Mietzner, Richard Falk, Rajesh Beri, Mark Caswell
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Publication number: 20230183623Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: ApplicationFiled: February 1, 2023Publication date: June 15, 2023Inventors: Michael Mietzner, Rajesh Beri, Edward Gunderson
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Patent number: 11597900Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: GrantFiled: May 8, 2019Date of Patent: March 7, 2023Assignee: Lonza Ltd.Inventors: Michael Mietzner, Rajesh Beri, Edward Gunderson
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Patent number: 11519515Abstract: A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.Type: GrantFiled: September 3, 2019Date of Patent: December 6, 2022Assignee: LONZA LTDInventor: Michael Mietzner
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Publication number: 20200332241Abstract: An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.Type: ApplicationFiled: April 21, 2020Publication date: October 22, 2020Inventors: Michael MIETZNER, Richard FALK, Rajesh BERI, Mark CASWELL
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Patent number: 10808216Abstract: Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (?in).Type: GrantFiled: October 5, 2016Date of Patent: October 20, 2020Assignee: Lonza LtdInventors: Michael Mietzner, Jim Heimbach, Andrew Harris
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Publication number: 20200147556Abstract: A process and system for cleaning semipermeable membranes is described that is particularly well suited for cleaning membranes contained in a water purification system, such as a reverse osmosis process. In order to clean the filter membranes, the membranes are placed in a cleaning chamber capable of allowing a reduction in pressure. In one embodiment, for instance, the membranes are contained in a filter housing and the filter housing is converted into a cleaning chamber by sealing off at least one end. The membranes are then submerged in a cleaning fluid and the pressure within the cleaning chamber is reduced causing the cleaning fluid to form bubbles. The process and system of the present disclosure is well suited to cleaning filter membranes, particularly ceramic membranes, in-line without having to remove the membranes from the water purification system.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Inventor: Michael Mietzner
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Publication number: 20200003316Abstract: A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.Type: ApplicationFiled: September 3, 2019Publication date: January 2, 2020Inventor: Michael Mietzner
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Patent number: 10436338Abstract: A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.Type: GrantFiled: December 8, 2017Date of Patent: October 8, 2019Assignee: Lonza LtdInventor: Michael Mietzner
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Publication number: 20190264151Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: ApplicationFiled: May 8, 2019Publication date: August 29, 2019Inventors: Michael MIETZNER, Rajesh BERI, Edward GUNDERSON
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Patent number: 10370629Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: GrantFiled: June 22, 2017Date of Patent: August 6, 2019Assignee: Lonza LimitedInventors: Michael Mietzner, Rajesh Beri, Edward Gunderson
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Publication number: 20180163882Abstract: A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.Type: ApplicationFiled: December 8, 2017Publication date: June 14, 2018Inventor: Michael Mietzner
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Publication number: 20180094231Abstract: Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (?in).Type: ApplicationFiled: October 5, 2016Publication date: April 5, 2018Inventors: Michael Mietzner, Jim Heimbach, Andrew Harris
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Publication number: 20170369828Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: ApplicationFiled: June 22, 2017Publication date: December 28, 2017Inventors: Michael MIETZNER, Rajesh BERI, Edward GUNDERSON