Abstract: A medical device assembly comprises a medical device, such as a urinary catheter, comprising an insertable part and a non-insertable part. The insertable part comprises an elongate shaft provided with a hydrophilic coating or surface. The assembly further comprises a wetting fluid compartment arranged to encircle at least a part of the medical device, and preferably at least a part of the non-insertable part, and an aqueous fluid arranged in the wetting fluid compartment. At least one of the aqueous fluid and the hydrophilic coating or surface comprises at least one surfactant. The hydrophilic coating or surface is maintained essentially separated from the aqueous fluid, and arranged to become wetted by movement of the elongate shaft through the wetting fluid compartment.

Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.

Abstract: A cardiac assist device includes an expandable cup with a pumping chamber having at least one inflow aperture, an outflow nozzle in communication with the chamber, and a volume displacement member inside the chamber. The volume displacement member is cyclically movable between a low-volume state and a high-volume state at a frequency F, wherein a displacement volume of blood Vd is displaced from the chamber through the nozzle during each cycle. When the volume displacement member moves at frequency F, the device increases momentum of blood flowing through the device such that flow rate of blood exiting the nozzle is substantially greater than the frequency F multiplied by the displacement volume Vd. In some embodiments, the volume displacement member includes a balloon having a proximal region that is distanced from an inner wall of the chamber more than a distal region of the balloon when the balloon is fully inflated.

Abstract: A manifold for connection to a waste collection vacuum device. The manifold includes suction port tubes and a vacuum port that define interconnected fluid communication pathways such that no walls define proximal and distal ends of the manifold. Tabs are coupled to at least one of the interconnected fluid communication pathways. The tabs interface with keyed surfaces of the waste collection vacuum device so as to facilitate positive location and mechanical fixation with the waste collection vacuum device. A web of material may extend between the suction port tubes to increase torsional strength of the manifold. There may be two webs of material with each coupled to opposing pairs of four suction port tubes. The vacuum port may be a single vacuum port.

Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: The invention relates to a transfer system (1) for use in a barrier system (2) and to a beta component (8) for use in a transfer system (1) and to a barrier system (2) and to a production facility (3).

Abstract: Monoorgano tin trialkoxide compounds having chemical formula R?SnX3 and containing less than about 5 mol % R?2SnX2 are described. R? is an optionally substituted organic substituent having about 1 to about 20 carbon atoms and each X is independently ORf, wherein Rf is a fluorinated organic substituent having about 1 to about 20 carbon atoms. Methods for synthesizing and purifying these compounds are also provided. The monoorgano tin compounds may be used for the formation of high-resolution EUV lithography patterning precursors and are attractive due to their high purity and minimal concentration of diorgano tin impurities.

Abstract: Disclosed are messenger RNA molecules and related compositions incorporating a 4?-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4?-thio modified mRNA provides for enhanced stability and/or reduced immunogenicity in in vivo therapies.

Abstract: Refractory-reinforced multiphase high entropy alloys (RHEA's) advantageously providing high strength and fracture toughness in an as AM-deposited solidified condition and other conditions are described.

Abstract: We disclose novel methods for infiltrating gallium or an alloy thereof into a porous scaffold. Such methods include selecting or providing a porous scaffold; and using a centrifuge to at least partially fill the porous scaffold with gallium or an alloy thereof. The void fraction of the filled-coated scaffold is preferably no more than about 10%. In some embodiments and implementations, the methods further include forming a coating on the porous scaffold to enhance wetting of the scaffold to gallium before infiltration with the centrifuge. With the coating, the void fraction of the filled-coated scaffold may be advantageously reduced to be no more than about 2%. Cleaning step(s) may be further provided to remove oxides from the scaffolds before infiltration with the centrifuge.

Abstract: A passenger seat for facilitating seating passengers with reduced mobilities (PRM) in a conveyance such as an aircraft. The passenger seat includes a motion subassembly and a decoupling mechanism configured to couple the motion assembly to the seat back, and decouple the motion assembly from the seat back to lock the seat back in an upright position such that the passenger seat can be translated forward to a position nearer, for example, an aisle. In use, decoupling and seat back locking occur in a synchronous manner, as does coupling and seat back unlocking action thereby allowing seat back recline motion. In embodiments, the passenger seat includes a manual release lever for actuating the decoupling mechanism to decouple the seat back motion subassembly.

Abstract: A gas turbine engine includes a steam generating system, and a combustion section having a first combustor and a second combustor in fluid communication with a secondary combustion zone of the first combustor. The second combustor is operable to receive compressor bleed air and fuel, along with steam from the steam generating system. During a non-idle operating state and a power-augmentation operating state, when the steam system is operable, steam is provided to the second combustor and then to the secondary combustion zone of the first combustor. When the steam generating system is inoperable, the fuel and bleed air are provided to the second combustor and combusted, and combustion products are provided to the first combustor. When the steam generating system is partially operable, the steam, the bleed air, and the fuel are provided to the second combustor, and combustion products are provided to the first combustor.

Abstract: An apparatus for cooling one or more samples includes a cryostat with a first wall forming an inner chamber with an opening for receiving the one or more samples. A second wall forms an outer chamber adapted to insulate the inner chamber and a channel leading to the opening of the inner chamber. A seal selectively seals the opening to the inner chamber, and a cryocooler thermally links to the inner chamber, such as by way of a flexible strap. The inner chamber may entirely surround the outer chamber, and yet via the channel allow for the removal of the one or more samples from the inner chamber while maintaining the evacuated outer chamber. The inner chamber may also be fully contained within the outer chamber, which may be evacuated. Related methods are also disclosed.

Abstract: The present disclosure relates to a multi-circuit heating, ventilation, and air conditioning (“HVAC”) system for use with a first refrigerant in a first refrigerant circuit and a second refrigerant in a second refrigerant circuit. The second refrigerant circuit is fluidically isolated from the first refrigerant circuit. Additionally, a first sensor is operable to detect a leak of at least one of the first and second refrigerants or is operable to measure temperature or pressure from the first refrigerant circuit or the second refrigerant. The multi-circuit HVAC system further including a controller programmed to receive the measurement from the sensor to identify the circuit or circuits that are leaking, to turn off operation of the leaking circuit or circuits, and if only one circuit is leaking, operate only the other of the circuits.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to remove a steering wheel of a vehicle. As disclosed herein, a non-transitory computer-readable medium comprising instructions which, when executed, cause processor circuitry of a vehicle to: detect a request to remove a steering wheel from a steering system of a vehicle; verify a user identity based on a user profile, the user profile stored in a memory associated with the vehicle; determine whether a disengagement criterion is satisfied; and after the user identity is detected and the disengagement criterion is satisfied, disengage a lock to enable removal of the steering wheel from the steering system of the vehicle.

Abstract: A gas turbine engine has a turbomachine comprising compressor, combustion, and turbine sections. The gas turbine engine defines a maximum exhaust gas temperature, a maximum drive turbine shaft torque, and a corrected specific power. The gas turbine engine includes a nozzle vane and an engine casing defining a fluid supply plenum. The engine casing is configured to route cooling fluid from the fluid supply plenum to the nozzle vane. The routing of the cooling fluid facilitates cooling of the nozzle vane and increases an overall pressure ratio of the gas turbine engine. Integration of the cooling fluid routing within the engine casing reduces parasitic bleed air losses, enables tighter turbine stage spacing, and improves the thermal efficiency of the engine, thereby enhancing performance at elevated pressure ratios.

Abstract: A system includes a condensate injection system configured to fluidly couple to a combustion chamber of a reciprocating engine and an exhaust gas recirculation (EGR) system of the reciprocating engine. The condensate injection system includes a condensate tank configured to store condensate collected from the EGR system. The condensate injection system also includes a pump fluidly coupled to the condensate tank. The condensate injection system also includes an injector fluidly coupled to the pump. The injector is configured to inject condensate into the combustion chamber during a first portion of an engine cycle of the reciprocating engine. The first portion of the engine cycle includes at least part of a power stroke and/or an exhaust stroke of the engine cycle.

Abstract: Embodiments relate to a system, a computing device, a computer readable storage medium, and a method to detect a personal care composition. In embodiments, an image capture device may capture values for infrared (IR) radiation from an interaction between light and an ingredient of the personal care composition. In embodiments, a processor may detect the presence of the personal care composition based on the valued for the IR radiation captured by the image capture device. Embodiments further relate to a personal care composition including one or more ingredients to be used as a marker for the personal care composition, selected for an ability to exhibit diffuse reflection or absorbance of IR radiation.

Abstract: A system for facilitating detection of defects in materials is configurable to: (i) access a set of input images comprising a plurality of cross-sectional images providing a representation of a component; and (ii) process the set of input images using an off-nominal anomaly detection model by, for each particular cross-sectional image of the plurality of cross-sectional images: (a) generate a set of patch embedding vectors comprising a patch embedding vector for each image patch of the particular cross-sectional image; (b) generate a set of difference metrics based on the set of patch embedding vectors and a probabilistic representation of a nominal component; and (c) determine a set of anomaly scores for the particular cross-sectional image based on the set of difference metrics.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.