Patents by Inventor Michael Molla

Michael Molla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Computer software to assist in identifying SNPS with microarrays
    Patent number: 7904250
    Abstract: The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: March 8, 2011
    Assignee: Roche Nimblegen, Inc.
    Inventors: Michael Molla, Todd Richmond, Steven Smith, Thomas Albert
  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20100222232
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: April 5, 2010
    Publication date: September 2, 2010
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch
  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20080194414
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: January 8, 2008
    Publication date: August 14, 2008
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch
  • Computer software to assist in identifying SNPS with microarrays
    Publication number: 20060014164
    Abstract: The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
    Type: Application
    Filed: January 26, 2005
    Publication date: January 19, 2006
    Inventors: Michael Molla, Todd Richmond, Steven Smith, Thomas Albert