Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), resveratrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: A shunt operable to be implanted on an eye is provided. The shunt includes a vein fluidic channel operable to be in fluid communication with an interior of the eye and operable to receive aqueous fluid from the interior of the eye. A body is fluidly coupled with the vein fluidic channel. A valve is disposed within the body and is operable to regulate intraocular pressure in the eye by opening and closing based on pressure from the aqueous fluid. A plurality of outlets are in fluid communication with the body opposite the vein fluidic channel in relation to the valve. The outlets are operable to release the aqueous fluid to the sclera of the eye.

Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: Aspects and examples disclosed herein are directed to data enrichment on insulated appliances. An appliance for performing knowledge mining in a disconnected state is operative to: ingest data of a first type from a first data source coupled to the appliance; enrich at least a first portion of the ingested data, when in the disconnected state, with at least one of the cognitive functions of the plurality of containerized cognitive functions; identify at least a second portion of the ingested data for enrichment by a cognitive function that is not within the plurality of containerized cognitive functions; store the enriched data in an index; triage the ingested data and the enriched data in the index for uploading; upload the triaged data when reconnected to a network; and import an updated plurality of containerized cognitive functions when reconnected.

Abstract: Aspects and examples disclosed herein are directed to data enrichment on insulated appliances. An appliance for performing knowledge mining in a disconnected state is operative to: import a plurality of containerized cognitive functions and a seed index from a service node, when the appliance is initially connected to a network; ingest data of a first type from a first data source coupled to the appliance; enrich at least a first portion of the ingested data, when in the disconnected state, with at least one of the cognitive functions of the plurality of containerized cognitive functions; identify at least a second portion of the ingested data for enrichment by a cognitive function that is not within the plurality of containerized cognitive functions; based at least on knowledge extracted from the enriched data, further enrich the enriched data; and grow the seed index into an enhanced index with the enriched data.