Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), resveratrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: Aspects and examples disclosed herein are directed to data enrichment on insulated appliances. An appliance for performing knowledge mining in a disconnected state is operative to: ingest data of a first type from a first data source coupled to the appliance; enrich at least a first portion of the ingested data, when in the disconnected state, with at least one of the cognitive functions of the plurality of containerized cognitive functions; identify at least a second portion of the ingested data for enrichment by a cognitive function that is not within the plurality of containerized cognitive functions; store the enriched data in an index; triage the ingested data and the enriched data in the index for uploading; upload the triaged data when reconnected to a network; and import an updated plurality of containerized cognitive functions when reconnected.

Abstract: Aspects and examples disclosed herein are directed to data enrichment on insulated appliances. An appliance for performing knowledge mining in a disconnected state is operative to: import a plurality of containerized cognitive functions and a seed index from a service node, when the appliance is initially connected to a network; ingest data of a first type from a first data source coupled to the appliance; enrich at least a first portion of the ingested data, when in the disconnected state, with at least one of the cognitive functions of the plurality of containerized cognitive functions; identify at least a second portion of the ingested data for enrichment by a cognitive function that is not within the plurality of containerized cognitive functions; based at least on knowledge extracted from the enriched data, further enrich the enriched data; and grow the seed index into an enhanced index with the enriched data.