Abstract: Provided herein are methods for screening edited genomic sequences for their effect on expression of a target gene, and for designing a target sequence edit for introducing to a target sequence of a nucleic acid molecule. Also provided are compositions and cells including the edited sequences, and methods for their use in preventing or treating a disease.

Abstract: Systems, methods, and devices are disclosed for wireless electrocardiogram (EKG) monitoring. An example method may detect wireless electrodes placed on a patient's body, each with a unique identifier. The example method may also display optimal electrode placement locations on the device's screen. Additionally, the example method may verify the placement of the wireless electrodes using the mobile device. The example method may also transmit voltage measurements from the electrodes to the mobile device. Additionally, the example method may integrate the voltage measurements into an EKG reading using the mobile device.

Abstract: A system for building-specific multi-peril risk assessment and mitigation is disclosed. The system comprises a multi-peril hazard module, a processor, a database and a graphical network module. The multi-peril hazard module is configured to obtain hazard information and create a multi-peril event catalogue configured to generate intensity measures for multiple perils. The processor is configured to derive a peril vulnerability function and determine building-specific risk assessment results based on the hazard information and the peril vulnerability function. The database is configured to store the derived plurality of peril vulnerability functions. The graphical network module is configured to create probabilistic networks, wherein the probabilistic networks are connected to the determined building-specific risk assessment results of the peril vulnerability functions that have strong interdependencies and determine a multi-peril risk associated with the building.

Abstract: A planar device for a pedal-equipped apparatus with a planar member attached to the inward portion of a pedal to protect a rider's body and/or clothing from contact with equipment components during the entire circular pedal rotation. This member may change from a closed, unexpanded position to an expanded position.

Abstract: A system for building-specific multi-peril risk assessment and mitigation is disclosed. The system comprises a multi-peril hazard module, a processor, a database and a graphical network module. The multi-peril hazard module is configured to obtain hazard information and create a multi-peril event catalogue configured to generate intensity measures for multiple perils. The processor is configured to derive a peril vulnerability function and determine building-specific risk assessment results based on the hazard information and the peril vulnerability function. The database is configured to store the derived plurality of peril vulnerability functions. The graphical network module is configured to create probabilistic networks, wherein the probabilistic networks are connected to the determined building-specific risk assessment results of the peril vulnerability functions that have strong interdependencies and determine a multi-peril risk associated with the building.

Abstract: A recording arrangement is provided including at least one outer enclosure configured to receive and maintain therein a plurality of video recording devices and a matching plurality of audio recording devices, deployment hardware configured to deploy the plurality of video recording devices to a desired location, means for moving the deployment hardware, and electrical component hardware. The at least one outer enclosure is portable to different physical locations. The electrical component hardware is configured to deploy the plurality of video recording devices in a cross-shooting orientation wherein a first subject on a left side is video recordable by a first video recording device positioned on a right side and a second subject on the right side is video recordable by a second video recording device on the left side.

Abstract: A recording arrangement is provided including at least one outer enclosure configured to receive and maintain therein a plurality of video recording devices and a matching plurality of audio recording devices, deployment hardware configured to deploy the plurality of video recording devices to a desired location, means for moving the deployment hardware, and electrical component hardware. The at least one outer enclosure is portable to different physical locations. The electrical component hardware is configured to deploy the plurality of video recording devices in a cross-shooting orientation wherein a first subject on a left side is video recordable by a first video recording device positioned on a right side and a second subject on the right side is video recordable by a second video recording device on the left side.

Abstract: A recording arrangement is provided including an outer enclosure including a plurality of video recording devices and a matching plurality of audio recording devices, at least one extender configured to deploy the plurality of video recording devices to a desired location, extender deployment hardware configured to drive the at least one extender, and electronics configured to drive the at least one extender, the electronics comprising a power supply, a timecode generator, a plurality of recorders, and an internet protocol (IP) assembly configured to facilitate interface with a remote computing device.

Abstract: A recording arrangement is provided including an outer enclosure including a plurality of video recording devices and a matching plurality of audio recording devices, at least one extender configured to deploy the plurality of video recording devices to a desired location, extender deployment hardware configured to drive the at least one extender, and electronics configured to drive the at least one extender, the electronics comprising a power supply, a timecode generator, a plurality of recorders, and an internet protocol (IP) assembly configured to facilitate interface with a remote computing device.

Abstract: The present design is directed to a system for enhancing user selection of information. The system includes an information providing element configured to provide information related to a first entity to a user, a partitioning element configured to partition the information into a set of partitioned items, means for the user to apply at least one tag to each item in the set of partitioned items, a representation element configured to represent all tags applied to the set of partitioned items to the user in a graphical format representation, and an interaction element configured to enable the user to select a desired partitioned item for review based on all tags applied in the graphical format representation. The system thus includes a video tagging/playback tool useful in creating an enhanced entertainment experience.

Abstract: A method and apparatus for making real-time measurements of downhole properties during cement plug placement. A wired placement conduit is lowered downhole releasing a sensor package. The sensor package is capable of measuring downhole properties in real-time in the period while the cement plug sets.

Abstract: A building structure in an outrigger configuration having a building core, at least one perimeter column, and at least one outrigger beam having a main body portion connected to the building core, an end portion distal from the building core in a direction of the at least one perimeter column and a vane portion extending from the end portion. At least one damper having a high-viscosity fluid container connected is connected to the at least one perimeter column and the vane portion extends into the high-viscosity fluid container to couple the building core to the at least one perimeter column, such that when the building structure is subjected to lateral loads and the building core is displaced with respect to the at least perimeter column, high-viscosity fluid within the high-viscosity fluid container is sheared by the vane to damp vibrations and provide coupling in the building structure.

Abstract: A building structure in an outrigger configuration having a building core, at least one perimeter column, and at least one outrigger beam having a main body portion connected to the building core, an end portion distal from the building core in a direction of the at least one perimeter column and a vane portion extending from the end portion. At least one damper having a high-viscosity fluid container connected is connected to the at least one perimeter column and the vane portion extends into the high-viscosity fluid container to couple the building core to the at least one perimeter column, such that when the building structure is subjected to lateral loads and the building core is displaced with respect to the at least perimeter column, high-viscosity fluid within the high-viscosity fluid container is sheared by the vane to damp vibrations and provide coupling in the building structure.

Abstract: A building structure including a plurality of vertical elements extending from a ground surface with at least a first of the vertical elements connected to a second of the vertical elements by a coupling member, the coupling member includes a damping element for damping vibrations in the building structure resulting from relative movement between the first and second vertical elements due to lateral loads applied to the building structure. The damping element undergoes deformation due to the relative movement between the vertical elements causing the damping material to be activated in shear. At least one of a first and second fuse member is connected to at least one of first and second ends of the damping element respectively.

Abstract: The present disclosure relates to a method to determine a clock signal when separate clocks are used. In one embodiment, a disciplined clock system comprising an update subsystem and a synthesis subsystem is provided. A first clock phase estimate is provided to the update subsystem and used, along with the update subsystem, to determine a frequency offset estimate and a phase offset estimate. The clock signal is determining using the frequency offset estimate, the phase offset estimate, and the synthesis subsystem. Alternatively, two clocks can be synchronized by generating a signal associated with a first clock; modulating the signal; transmitting the modulated signal; receiving the modulated signal by a receiver associated with a second clock; correlating the received signal; determining the time of arrival of the received signal; determining the time difference between the two clocks; and synchronizing the two clocks.

Abstract: A method and apparatus for making real-time measurements of downhole properties during cement plug placement. A wired placement conduit (14) is lowered downhole releasing a sensor package (20). The sensor package is capable of measuring downhole properties in real-time in the period while the cement plug sets.

Abstract: A building structure including a plurality of vertical elements extending from a ground surface with at least a first of the vertical elements connected to a second of the vertical elements by a coupling member, the coupling member includes a damping element for damping vibrations in the building structure resulting from relative movement between the first and second vertical elements due to lateral loads applied to the building structure. The damping element undergoes deformation due to the relative movement between the vertical elements causing the damping material to be activated in shear. At least one of a first and second fuse member is connected to at least one of first and second ends of the damping element respectively.

Abstract: The present disclosure relates to a method to determine a clock signal when separate clocks are used. In one embodiment, a disciplined clock system comprising an update subsystem and a synthesis subsystem is provided. A first clock phase estimate is provided to the update subsystem and used, along with the update subsystem, to determine a frequency offset estimate and a phase offset estimate. The clock signal is determining using the frequency offset estimate, the phase offset estimate, and the synthesis subsystem. Alternatively, two clocks can be synchronized by generating a signal associated with a first clock; modulating the signal; transmitting the modulated signal; receiving the modulated signal by a receiver associated with a second clock; correlating the received signal; determining the time of arrival of the received signal; determining the time difference between the two clocks; and synchronizing the two clocks.

Abstract: A damping system including a first set of plates having one end thereof attached to a first vertically extending structural element, a second set of plates having one end thereof attached to a second vertically extending structural element spaced in a horizontal direction from the first vertically extending structural element, and arranged such that the first set of plates has a second end portion extending towards and overlapping with a second end portion of the second set of plates at an overlapping region, and further including an energy dissipating material provided in the overlapping region for connecting the first set of plates and the second set of plates.