Patents by Inventor Michael Mullican

Michael Mullican has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030225151
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: January 2, 2003
    Publication date: December 4, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang
  • Acyclic and cyclic amine derivatives
    Publication number: 20030144253
    Abstract: The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 30, 2002
    Publication date: July 31, 2003
    Inventors: Michael Mullican, David Lauffer, Roger Tung
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6593357
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: July 15, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Jingrong Cao, Michael Hale, Christopher Baker, Francois Maltais, James Janetka, Michael Mullican, Guy Bemis, Xiaoling Xie, Judith Straub, Qing Tang
  • Cyclized amide derivatives
    Publication number: 20030130256
    Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: February 5, 2003
    Publication date: July 10, 2003
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • CAK inhibitors and uses thereof
    Publication number: 20030119793
    Abstract: The present invention relates to compounds useful as inhibitors of CAK, compositions thereof. The present invention also relates to methods using the compositions for treating CAK-mediated diseases, such as fungal infections.
    Type: Application
    Filed: June 6, 2002
    Publication date: June 26, 2003
    Inventors: Brian Ledford, Cameron Stuver Moody, Michael Mullican, Mark Namchuk
  • Azo amino acids derivatives
    Publication number: 20030109526
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 12, 2003
    Inventors: David Lauffer, Michael Mullican
  • Cyclized amide derivatives
    Patent number: 6552041
    Abstract: The present invention relates to cyclized amide derivatives of formula (I) These cyclized amide derivatives are useful for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 22, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • Azo amino acids derivatives
    Patent number: 6528533
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: David Lauffer, Michael Mullican
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6528509
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmacuticals, Incorporated
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030040536
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 5, 2001
    Publication date: February 27, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Bicyclic derivatives
    Publication number: 20020123507
    Abstract: The present invention relates to bicylic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: September 5, 2002
    Inventors: David Lauffer, Michael Mullican
  • Cyclic amine derivatives
    Publication number: 20020123493
    Abstract: The present invention relates to cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: September 5, 2002
    Inventors: Michael Mullican, David Lauffer
  • Beta-amino acid derivatives
    Publication number: 20020123492
    Abstract: The present invention relates beta-amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: September 5, 2002
    Inventors: David Lauffer, Michael Mullican
  • Amino-alkyl derivatives
    Publication number: 20020111347
    Abstract: The present invention relates to amino-alkyl derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 15, 2002
    Inventors: Scott Harbeson, Michael Mullican
  • Cyclized amide derivatives
    Publication number: 20020107239
    Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • N-substituted glycine derivatives
    Publication number: 20020107240
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • N-heterocyclic derivatives
    Publication number: 20020107241
    Abstract: The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Azo amino acids derivatives
    Publication number: 20020103190
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 1, 2002
    Inventors: David Lauffer, Michael Mullican
  • Compounds possessing neuronal activity
    Publication number: 20020013351
    Abstract: The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that utilize them can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma.
    Type: Application
    Filed: June 27, 2001
    Publication date: January 31, 2002
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Patricia McCaffrey, Perry M. Novak, Michael Mullican
  • Compounds possessing neuronal activity
    Patent number: 6268384
    Abstract: The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that utilize them can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: July 31, 2001
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Perry M. Novak, Michael Mullican