Patents by Inventor Michael Mutolo

Michael Mutolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF SKIN DISEASES AND DISORDERS USING INHIBITORS OF KALLIKREIN-RELATED PEPTIDASES (KLK)
    Publication number: 20230340488
    Abstract: Provided herein are compositions and methods for inhibiting the expression and/or activity of kallikrein-related peptidase (KLK) (e.g., KLK5 and KLK7) genes and/or KLK (e.g., KLK5 and KLK7) gene products using oligonucleotide-based therapy. In some embodiments, the compositions are spherical nucleic acids (SNAs) targeting a region of a KLK5 gene and/or gene product and a second synthetic oligonucleotide targeting a region of a KLK7 gene and/or a KLK7 gene product. Such compositions and methods are useful, for instance, in the treatment, prevention, and/or amelioration of diseases or disorders associated with the dysregulation of KLK function.
    Type: Application
    Filed: August 6, 2021
    Publication date: October 26, 2023
    Applicants: Exicure Operating Company, SevenScore Pharmaceuticals, LLC
    Inventors: Bart Anderson, Michael Mutolo
  • LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS FOR SURVIVAL OF MOTOR NEURON (SMA) INHIBITORS
    Publication number: 20210002640
    Abstract: Compositions related to spherical nucleic acids (SNAs) and structures with antisense oligonucleotides and methods of treatment of diseases and disorders are disclosed herein.
    Type: Application
    Filed: February 28, 2019
    Publication date: January 7, 2021
    Applicant: Exicure, Inc.
    Inventors: Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla, Michael Mutolo