Patents by Inventor Michael N. Margolies

Michael N. Margolies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ouabain-specific monoclonal antibodies
    Patent number: 7348412
    Abstract: The invention relates to a monoclonal antibody or antigen binding fragment thereof having binding specificity for ouabain, wherein the antibody or antigen binding fragment does not crossreact with digoxin. Preferably the anti-ouabain monoclonal antibody can bind ouabain with an affinity of at least about 10?7M, preferably 10?8M, and more preferably 10?9M. The invention also relates to diagnostic and therapeutic uses of the monoclonal antibodies described herein.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: March 25, 2008
    Assignee: The General Hospital Corporation
    Inventors: Behnaz Parhami-Seren, Michael N. Margolies, Garner T. Haupert, Jr.
  • Antibody fragment compositions and process
    Patent number: 4355023
    Abstract: Immunologically active rabbit IgG antibody fragment compositions are produced by isolating the anti-light variable chain of rabbit IgG and/or the anti-heavy variable chain of rabbit IgG and combining them with each other or with the complementary heavy or light chain of rabbit IgG.
    Type: Grant
    Filed: September 30, 1980
    Date of Patent: October 19, 1982
    Assignee: The Massachusetts General Hospital
    Inventors: Paul H. Ehrlich, Gary R. Matsueda, Michael N. Margolies, Edgar Haber