Patents by Inventor Michael Naesby

Michael Naesby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10760062
    Abstract: Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: September 1, 2020
    Assignee: EVOLVA SA
    Inventors: Michael Naesby, Ernesto Simón Vecilla, Michael Eichenberger, Beata Joanna Lehka, Walden Emil Bjørn-Yoshimoto, Niels Bjerg Jensen
  • Publication number: 20200123583
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2019
    Publication date: April 23, 2020
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina Tavares
  • Patent number: 10435730
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: October 8, 2019
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • Publication number: 20190071474
    Abstract: The invention relates to recombinant microorganisms and methods for producing gibberellin compounds and gibberellin precursors.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 7, 2019
    Inventors: Esben Halkjaer Hansen, Nina Nicoline Rasmussen, Michael Naesby, Jane Dannow Dyekjaer, Simon Carlsen, Adam Matthew Takos, Nicholas Ohler
  • Patent number: 10190140
    Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: January 29, 2019
    Assignee: EVOLVA SA
    Inventors: Thomas Oestergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen
  • Publication number: 20180371513
    Abstract: Methods for producing anthocyanin by expression in a microorganism are disclosed including culturing of the microorganism under anthocyanin producing conditions, wherein the microorganism has an operative metabolic pathway including at least one heterologous enzyme activity, the pathway producing anthocyanin from simple sugars or other simple carbon sources.
    Type: Application
    Filed: September 21, 2016
    Publication date: December 27, 2018
    Inventors: Michael Naesby, Zina Zokouri, David Fischer, Michael Eichenberger, Anders Hansson
  • Patent number: 10119154
    Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: November 6, 2018
    Assignee: Evolva SA
    Inventors: Jorgen Hansen, Patricia Hoyle, Michael Naesby, Joseph M. Sheridan, Jonathan R. Heal
  • Publication number: 20180142216
    Abstract: Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.
    Type: Application
    Filed: June 6, 2016
    Publication date: May 24, 2018
    Inventors: Michael NAESBY, Ernesto SIMÓN VECILLA, Michael EICHENBERGER, Beata Joanna LEHKA, Walden Emil BJØRN-YOSHIMOTO, Niels Bjerg JENSEN, Jane Dannow DYEKJÆR
  • Publication number: 20180080054
    Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
    Type: Application
    Filed: August 1, 2017
    Publication date: March 22, 2018
    Inventors: Thomas M. Ostergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen
  • Patent number: 9834800
    Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: December 5, 2017
    Assignee: Evolva SA
    Inventors: Thomas Oestergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen
  • Patent number: 9828617
    Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: November 28, 2017
    Assignees: BASF SE, Evolva SA
    Inventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
  • Publication number: 20170321238
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: February 22, 2017
    Publication date: November 9, 2017
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Halkjaer Hansen, Ernesto Simon, Sabina Tavares
  • Patent number: 9631215
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: April 25, 2017
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • Publication number: 20170088589
    Abstract: The present invention relates e.g. to methods of producing statins in transgenic, non-filamentous microorganisms such as Saccharomyces cerevisiae. In addition, the present invention relates to the transgenic, non-filamentous microorganisms as such as well as various uses of transmembrane statin efflux pump(s) originating from various filamentous fungi. Moreover, the present invention relates to the transferring the compactin, lovastatin or monacolin K gene cluster originating from non-filamentous fungi into easily fermentable microorganisms, followed by expression or overexpression of the efflux pump encoding genes in said microorganisms in order to increase the microorganisms resistance to statins which in turn allows for production of elevated concentrations of natural statins compared to statin-producing methods known in the art.
    Type: Application
    Filed: April 16, 2015
    Publication date: March 30, 2017
    Inventors: Rasmus John Normand Frandsen, Ane Ley, Michael Naesby
  • Publication number: 20150344920
    Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
    Type: Application
    Filed: December 23, 2013
    Publication date: December 3, 2015
    Applicant: Evolva SA
    Inventors: Jorgen Hansen, Patricia Hoyle, Michael Naesby, Joseph M. Sheridan, Jonathan R. Heal
  • Publication number: 20150225754
    Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
    Type: Application
    Filed: August 19, 2013
    Publication date: August 13, 2015
    Inventors: Thomas Oestergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen
  • Publication number: 20150211036
    Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
    Type: Application
    Filed: August 13, 2013
    Publication date: July 30, 2015
    Applicants: BASF SE, Evolva SA
    Inventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
  • Publication number: 20140329281
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 6, 2014
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina de Andrade Periera Tavares
  • Patent number: 8008459
    Abstract: In the present invention are disclosed concatemers of concatenated expression cassettes and vectors that enable the synthesis of such concatemers. The concatemer comprises in the 5??3? direction a cassette of nucleotide sequence of the general formula [rs2-SP-PR-X-TR-SP-rs1]n wherein rs1 and rs2 together denote a functional restriction site, SP individually denotes a spacer of at least two nucleotide bases, PR denotes a promoter, capable of functioning in a cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and SP individually denotes a spacer of at least two nucleotide bases, and n>/=2, and wherein at least a first cassette is different from a second cassette. The main purpose of these concatemers is the controllable and co-ordinated expression of large numbers of heterologous genes in a single host. Furthermore, the invention relates to a concatemer of cassettes of nucleotide sequences and a method for preparing the concatemers.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: August 30, 2011
    Assignee: Evolva SA
    Inventors: Neil Goldsmith, Alexandra M. P. Santana Sorensen, Soren V. S. Nielsen, Michael Naesby
  • Patent number: 6979536
    Abstract: A method for the determination of nucleic acids which is highly specific and simple comprises the formation of a triple stranded binding complex including two separate, different probe molecules and detecting the formation of the complex via the inclusion of one of the probes. The method can be used to differentiate between nucleic acids having a single base difference in sequence.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: December 27, 2005
    Assignee: PNA Diagnostics A/S
    Inventor: Michael Naesby