Patents by Inventor Michael Nantz

Michael Nantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9638695
    Abstract: A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for lung cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for lung cancer in the subject specimen.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: May 2, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Xiaoan Fu, Michael Nantz, Michael Bousamra
  • Publication number: 20170030892
    Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 2, 2017
    Inventors: Xiaoan Fu, Michael Nantz, Michael Bousamra, Victor van Berkel
  • Publication number: 20150064796
    Abstract: A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for lung cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for lung cancer in the subject specimen.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Inventors: Xiaoan Fu, Michael Nantz, Michael Bousamra
  • Patent number: 8663581
    Abstract: A chemical pre-concentrator is provided having a support structure, an airflow conduit, and a layer of a reactive chemical compound on a surface of the support structure is used for collecting and pre-concentrating at least one chemical analyte from a dilute sample. A method of concentrating a gaseous sample is provide that includes exposing the chemical pre-concentrator with a dilute gaseous sample that contains at least one chemical analyte; and forming a conjugate of the at least one chemical analyte. A method of diagnosing a disease state in a mammalian patient is provided using the chemical pre-concentrator.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: March 4, 2014
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Xiaoan Fu, Richard M. Higashi, Michael Nantz
  • Publication number: 20120252129
    Abstract: A chemical pre-concentrator is provided having a support structure, an airflow conduit, and a layer of a reactive chemical compound on a surface of the support structure is used for collecting and pre-concentrating at least one chemical analyte from a dilute sample. A method of concentrating a gaseous sample is provide that includes exposing the chemical pre-concentrator with a dilute gaseous sample that contains at least one chemical analyte; and forming a conjugate of the at least one chemical analyte. A method of diagnosing a disease state in a mammalian patient is provided using the chemical pre-concentrator.
    Type: Application
    Filed: March 27, 2012
    Publication date: October 4, 2012
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Xiaoan Fu, Richard Higashi, Michael Nantz
  • Publication number: 20060160746
    Abstract: The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the amiloride conjugates of the present invention for treating cancer or a central nervous system disease or disorder or for preventing or reducing ischemia-reperfusion injury. Further, kits are provided for the treatment of a central nervous system disease or disorder or for the prevention or reduction of ischemia-reperfusion injury using the amiloride conjugates of the present invention.
    Type: Application
    Filed: January 21, 2005
    Publication date: July 20, 2006
    Applicant: The Regents of the University of California
    Inventors: Fredric Gorin, Michael Nantz