Patents by Inventor Michael Naveh

Michael Naveh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Depot formulations of a local anesthetic and methods for preparation thereof
    Patent number: 10206876
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: February 19, 2019
    Assignee: PAINREFORM LTD.
    Inventors: Shimon Amselem, Michael Naveh
  • DEPOT FORMULATIONS OF A LOCAL ANESTHETIC AND METHODS FOR PREPARATION THEREOF
    Publication number: 20180049985
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Application
    Filed: May 2, 2017
    Publication date: February 22, 2018
    Applicant: PAINREFORM LTD.
    Inventors: Shimon AMSELEM, Michael NAVEH
  • Depot formulations of a hydrophobic active ingredient and methods for preparation thereof
    Patent number: 9849088
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a hydrophobic active pharmaceutical ingredient (API) of low water solubility but readily dissolved in alcohols and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: December 26, 2017
    Assignee: Painreform Ltd.
    Inventors: Shimon Amselem, Michael Naveh
  • Depot formulations of a local anesthetic and methods for preparation thereof
    Patent number: 9668974
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: June 6, 2017
    Assignee: PAINREFORM LTD.
    Inventors: Shimon Amselem, Michael Naveh
  • Compositions and methods for inhibiting gastric acid secretion
    Patent number: 9132082
    Abstract: The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+ ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: September 15, 2015
    Assignee: Vecta, Ltd.
    Inventors: Aleksey Kostadinov, Tal Atarot, Michael Naveh
  • Depot Formulations of a Hydrophobic Active Ingredient and Methods for Preparation Thereof
    Publication number: 20150148325
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a hydrophobic active pharmaceutical ingredient (API) of low water solubility but readily dissolved in alcohols and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 28, 2015
    Inventors: Shimon Amselem, Michael Naveh
  • Depot Formulations of a Local Anesthetic and Methods for Preparation Thereof
    Publication number: 20150111923
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Application
    Filed: May 9, 2013
    Publication date: April 23, 2015
    Inventors: Shimon Amselem, Michael Naveh
  • Nitric oxide donors and uses thereof
    Patent number: 7968575
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: June 28, 2011
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Compositions and Methods for Inhibiting Gastric Acid Secretion
    Publication number: 20110111039
    Abstract: The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
    Type: Application
    Filed: May 14, 2009
    Publication date: May 12, 2011
    Inventors: Aleksey Kostadinov, Tal Atarot, Michael Naveh
  • Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof
    Patent number: 7579477
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 25, 2009
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
    Patent number: 7498445
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 3, 2009
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
    Patent number: 7368577
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 6, 2008
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof
    Patent number: 7332513
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: February 19, 2008
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
    Patent number: 7189750
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 13, 2007
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Nitric oxide donors and uses thereof
    Publication number: 20070021382
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: May 5, 2005
    Publication date: January 25, 2007
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
    Publication number: 20060183912
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
    Publication number: 20060183718
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof
    Publication number: 20060183913
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
    Publication number: 20060069139
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: March 30, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having alkyl substuent(s) and uses thereof
    Publication number: 20060069138
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: March 30, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh