Abstract: One aspect of the invention provides a device for detecting an analyte in a sample. The device includes: a sample loading region, an imaging window, a well, and an absorbent pad. The sample loading region is in fluid communication with the well. The well is in fluid communication with the absorbent pad, such that when a fluid sample comprising solid support structures and a liquid carrier are applied to the sample loading region, the fluid sample travels to the well and at least part of the liquid carrier is absorbed into the absorbent pad.

Abstract: One aspect of the invention provides a method for assessing peripheral arterial function in a subject. The method includes: conducting diffuse correlation spectroscopy on a local region of the subject; applying pressure to restrict blood flow to the local region for a period of time; conducting diffuse correlation spectroscopy on the local region while the pressure is applied; releasing the pressure; and conducting diffuse correlation spectroscopy on the local region after the pressure is released. Another aspect of the invention provides a system including: a diffuse correlation spectroscopy device and a pressure cuff.

Abstract: One aspect of the invention provides a device for detecting an analyte in a sample. The device includes: a sample loading region, an imaging window, a well, and an absorbent pad. The sample loading region is in fluid communication with the well. The well is in fluid communication with the absorbent pad, such that when a fluid sample comprising solid support structures and a liquid carrier are applied to the sample loading region, the fluid sample travels to the well and at least part of the liquid carrier is absorbed into the absorbent pad.