Patents by Inventor Michael Nelbock-Hochstetter

Michael Nelbock-Hochstetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4182695
    Abstract: Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,R.sub.2 is the residue of a compound which can be condensed with formaldehyde and which contains at least one further reactive group,R.sub.3 is the residue of a bi- or poly-functional protein reagent,n is 0 or 1, andP is a biologically active protein;these compositions are obtainable by the reaction of a polyamides with amounts, equimolar to one another, of formaldehyde and of a compound condensable with formaldehyde, in a solvent for polyamides, reacting the product thereby obtained with a bi- or poly-functional protein reagent and coupling the resulting reaction product with the biologically active protein or protein substrate.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: January 8, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Jurgen Horn, Winfried Albert, Hans-Georg Batz, Michael Nelbock-Hochstetter
  • Patent number: 4144129
    Abstract: A new enzyme, cholesteroloxidase, is prepared by recovering same from microorganisms, preferably by washing a cholesterol-converting microorganism with butanol/water, disintegrating the microorganism culture and extracting same with a buffer solution containing a non-ionic surface-active agent, and isolating cholesterol oxidase from the extract.
    Type: Grant
    Filed: May 15, 1973
    Date of Patent: March 13, 1979
    Assignee: Boehringer Mannheim GmbH
    Inventors: Wolfgang Gruber, Hans U. Bergmeyer, Michael Nelbock-Hochstetter, Klaus Beaucamp, Gunter Holz, Johanna Gramsall, Gunter Lang
  • Patent number: 4081329
    Abstract: Carrier-bound macromolecular compounds, especially bioactive macromolecular compounds, are produced by reacting a macromolecular compound A with a coupling compound B containing at least one reactive function capable of coupling with compound A and at least one further reactive function capable of polymerization, adding to the resulting coupled reaction product AB an unswollen molecular sieve material having cross-linking sufficient to exclude penetration by compound A, and polymerizing the polymerizable group of the coupled product AB in the molecular sieve material to form a polymer body in the molecular sieve material and fix compound A on the surface of the molecular sieve material. Compound A can be, e.g., an enzyme, antibody or hormone, and coupling compound B typically contains, as the coupable function, an alkylation or acylation group such as oxirane, ethyleneimine, halide, acid halide, azide or anhydride groups, and, as the polymerizable function, a carbon-carbon or carbon-oxygen double bond.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: March 28, 1978
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dieter Jaworek, Karl-Heinz Botsch, Gunter Weimann, Michael Nelbock-Hochstetter, Helmut Determann
  • Patent number: 4038140
    Abstract: Biologically active proteins are bound onto an insoluble carrier by reacting such protein in an aqueous phase with a carrier comprising an activated polysaccharide having a hydrophilic graft co-polmyer grafted thereinto.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: July 26, 1977
    Assignee: Boehringer Mannheim G.m.b.H.
    Inventors: Dieter Jaworek, Joseph Maier, Michael Nelbock-Hochstetter
  • Patent number: 3969287
    Abstract: Carrier-bound proteins are prepared by reacting a protein in aqueous solution with a coupling compound having at least one group capable of acylating or alkylating proteins and at least one additional group capable of producing a bond with a carrier material, and reacting the resulting product with a carrier material, optionally forming the carrier material in situ by polymerization of a monomer or monomer mixture in the presence of said product.
    Type: Grant
    Filed: November 30, 1973
    Date of Patent: July 13, 1976
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dieter Jaworek, Michael Nelbock-Hochstetter, Klaus Beaucamp, Hans Ulrich Bergmeyer, Karl-Heinz Botsch