Abstract: Naftopidil,1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl)]-pipe razine, or of a salt thereof, is effective in the treatment of dysuria, particularly in causes of prostatic hypertrophy.

Abstract: A device used in detecting bacteria, fungi, and viruses in blood circulated through a particulate adsorbent material initially in a housing has a piston for pushing the adsorbent material from the housing for the detection. The piston preferably provides one passage for circulating the blood through the adsorbent material in the housing. An O-ring on the piston preferably indicates when the device has been used.

Abstract: The present invention provides a process for obtaining cholesterol esterase from micro-organisms of the genus Pseudomonas, wherein Pseudomonas sp. DSM 1280 or DSM 1281 is cultured in an appropriate culture medium in the presence of an inducer and the enzyme is obtained from the culture medium and/or from the cells.

Abstract: The present invention provides a process for obtaining cholesterol esterase from micro-organisms, wherein a micro-organism capable of cholesterol esterase formation is cultured in an appropriate nutrient medium in the presence of lecithin as inducer and the enzyme is obtained from the culture medium and/or from the cells.

Abstract: New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is -O-CH.sub.2 -CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;n is a whole number of from 2 to 7;m is 1, 2, 3 or 4,R is hydrogen, methyl, or cyanide; andR' is methyl or ethyl.have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.

Abstract: In a process for the determination of total or bound cholesterol by liberating any bound cholesterol using cholesterol esterase and simultaneously or subsequently determining the liberated cholesterol and any initially free cholesterol with a cholesterol reacting enzyme, the improvement comprising using as the cholesterol reacting enzyme an NAD or NADP-dependent cholesterol dehydrogenase obtained from an anaerobic microorganism, e.g., Eubacterium sp. ATCC 21408, or from mammalian tissue, e.g., liver.

Abstract: New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is --O--CH.sub.2 --CH.sub.2 when n is 2 and X is a succinimide ester group but otherwise is a single bond;N is a whole number of from 2 to 7;M is 1, 2, 3 or 4,R is hydrogen, methyl, or cyanide; andR' is methyl or ethyl;Have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.

Abstract: Crystalline salts of .beta.-nicotinamide-adenine-dinucleotide (.beta.-NAD), particularly alkali metal salts thereof are prepared in good yield and high quality to provide an analytically useful .beta.-NAD form.

Abstract: Cholesterol oxidase which oxidizes cholesterol with oxygen to give cholestenone and hydrogen peroxide, is prepared by culturing Nocardia erthropolis ATCC 17895, Nocardia erthropolis ATCC 4277, Nocardia formica ATCC 14811 or Proactinomyce erythropolis NCIB 9158 first on a peptone-containing mineral salt medium and thereafter on at least one sterol compound as the sole source of carbon, and then isolating the cholesterol oxidase formed from the cultured micro-organism, wherein said sterol compound is of the formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or together represent a double bond,R.sub.3 and R.sub.4 are hydrogen or together represent a double bond, andR.sub.5 is hydrogen or alkyl containing up to 3 carbon atoms.