Patents by Inventor Michael Nix

Michael Nix has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10433941
    Abstract: A dental solution dispenser includes a body having a first end, a second end, and including a front housing at the first end, a twist back at the second end, and a grip that interposes the front housing and the twist back. An applicator tip is coupled to the body at the first end, and an ampoule assembly is positioned within the body and includes an ampoule sealed at one end with a frangible seal and defining a fluid chamber for storing a dental solution. A mandrel extends longitudinally within the body and provides a piercing member. The twist back is rotatable relative to the grip to pierce the frangible seal with the piercing member. A trigger is coupled to the body and pivotable between an engaged position, where the trigger engages the ampoule assembly, and a disengaged position, where the trigger disengages the ampoule assembly.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 8, 2019
    Assignee: YOUNG MICROBRUSH, LLC
    Inventors: John Frymark, Todd Korup, Donald Melnikoff, Michael Nix, Robert E. Kreutzer, Jr., Richard Gaggioli, Wayne Siebrecht, Scott Rote, Aaron B. Eiger, Nathan Wicker, Kent Solberg
  • Publication number: 20160324608
    Abstract: A dental solution dispenser includes a body having a first end, a second end, and including a front housing at the first end, a twist back at the second end, and a grip that interposes the front housing and the twist back. An applicator tip is coupled to the body at the first end, and an ampoule assembly is positioned within the body and includes an ampoule sealed at one end with a frangible seal and defining a fluid chamber for storing a dental solution. A mandrel extends longitudinally within the body and provides a piercing member. The twist back is rotatable relative to the grip to pierce the frangible seal with the piercing member. A trigger is coupled to the body and pivotable between an engaged position, where the trigger engages the ampoule assembly, and a disengaged position, where the trigger disengages the ampoule assembly.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Applicant: Young Microbrush, LLC
    Inventors: John Frymark, Todd Korup, Donald Melnikoff, Michael Nix, Robert E. Kreutzer, JR., Richard Gaggioli, Wayne Siebrecht, Scott Rote, Aaron B. Eiger, Nathan Wicker, Kent Solberg
  • Patent number: 8192990
    Abstract: A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1?1 magnesium ions (Mg2+), the buffer solution having a buffer capacity of at least 20 mmol×1?1 ×pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol×1?1. An electric voltage is applied to the suspension.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: June 5, 2012
    Assignee: Lonza Cologne GmbH
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
  • Patent number: 8039259
    Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce the biologically active molecules into the cells using electric current. The buffer solution includes at least one of sodium succinate, mannitol and sodium lactobionate. The buffer solution has a buffer capacity of at least 20 mmol*l?1*pH?1 at a change in the from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol * l?1.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 18, 2011
    Assignee: Lonza Cologne GmbH
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
  • Patent number: 8003389
    Abstract: A method for introducing biologically active molecules into animal or human cells using electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution which has a buffer capacity of at least 20 mmol×l?1×pH?1 and an ionic strength of at least 200 mmol×l?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C. to form a suspension. The method further includes applying an electric voltage to the suspension so as to introduce the biologically active molecules into animal or human cells.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: August 23, 2011
    Assignee: Lonza Cologne GmbH
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
  • Publication number: 20110117654
    Abstract: A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1?1 magnesium ions (Mg2+), the buffer solution having a buffer capacity of at least 20 mmol×1?1×pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol×1?1. An electric voltage is applied to the suspension.
    Type: Application
    Filed: January 19, 2011
    Publication date: May 19, 2011
    Applicant: LONZA COLOGNE AG
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhaus, Michael Nix
  • Publication number: 20080145938
    Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce the biologically active molecules into the cells using electric current. The buffer solution includes HEPES and at least 10 mmol*1?1 magnesium ions (Mg2+). The buffer solution has a buffer capacity of at least 20 mmol*1?1*pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C. The buffer solution also has an ionic strength of at least 200 mmol*1?1.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 19, 2008
    Applicant: AMAXA AG
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
  • Publication number: 20080113436
    Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using electric current. The buffer solution includes at least one of sodium succinate, mannitol and sodium lactobionate. The buffer solution has a buffer capacity of at least 20 mmol*l?1*pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol*l?1.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 15, 2008
    Applicant: amaxa AG
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
  • Patent number: 7332332
    Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce biologically active molecules into cells using an electric current. The inventive buffer solution has a buffering capacity of at least 20 mmol?1×pH?1 and an ionic strength of at least 200 mmol×1?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25° C. The use of a buffer solution of this type allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in the buffer solution.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: February 19, 2008
    Assignee: Amaxa AG
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Müller-Hartmann, Kirsten Rothmann, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
  • Publication number: 20070110736
    Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using an electric current and to a method for introducing biologically active molecules into animal or human cells using an electric current and a buffer solution. The inventive buffer solution has a buffering capacity of at least 20 mmol*I?1*pH?1 and an ionic strength of at least 200 mmol* I?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25 ° C. The use of a buffer solution of this type in the corresponding method allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in said buffer solution.
    Type: Application
    Filed: November 9, 2006
    Publication date: May 17, 2007
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
  • Publication number: 20050064596
    Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using an electric current and to a method for introducing biologically active molecules into animal or human cells using an electric current and a buffer solution. The inventive buffer solution has a buffering capacity of at least 20 mmol*I?1*pH?1 and an ionic strength of at least 200 mmol*I?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25° C. The use of a buffer solution of this type in the corresponding method allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in said buffer solution.
    Type: Application
    Filed: April 23, 2002
    Publication date: March 24, 2005
    Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
  • Patent number: 5020025
    Abstract: A read-only memory for storing a plurality of bits of information. The read-only memory includes a plurality of memory cells arranged in an array with each memory cell including a capacitor having either a relatively high capacitance or a relatively low capacitance representing a bit of stored information. The read-only memory further includes a reading means for accessing each memory cell and providing a first or second output responsive to the capacitance level of the memory cell capacitance means.
    Type: Grant
    Filed: January 9, 1990
    Date of Patent: May 28, 1991
    Assignee: Advanced Micro Devices, Inc.
    Inventors: Michael Nix, Clayton D. English
  • Patent number: D766941
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: September 20, 2016
    Assignee: TD Ameritrade IP Company, Inc.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D781912
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: March 21, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D786301
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 9, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D786302
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 9, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D786303
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 9, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D786923
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 16, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D787552
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 23, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
  • Patent number: D788121
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: May 30, 2017
    Assignee: TD AMERITRADE IP COMPANY, INC.
    Inventors: Enrique Sallent, Michael Nix