Patents by Inventor Michael Nix
Michael Nix has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10433941Abstract: A dental solution dispenser includes a body having a first end, a second end, and including a front housing at the first end, a twist back at the second end, and a grip that interposes the front housing and the twist back. An applicator tip is coupled to the body at the first end, and an ampoule assembly is positioned within the body and includes an ampoule sealed at one end with a frangible seal and defining a fluid chamber for storing a dental solution. A mandrel extends longitudinally within the body and provides a piercing member. The twist back is rotatable relative to the grip to pierce the frangible seal with the piercing member. A trigger is coupled to the body and pivotable between an engaged position, where the trigger engages the ampoule assembly, and a disengaged position, where the trigger disengages the ampoule assembly.Type: GrantFiled: May 6, 2016Date of Patent: October 8, 2019Assignee: YOUNG MICROBRUSH, LLCInventors: John Frymark, Todd Korup, Donald Melnikoff, Michael Nix, Robert E. Kreutzer, Jr., Richard Gaggioli, Wayne Siebrecht, Scott Rote, Aaron B. Eiger, Nathan Wicker, Kent Solberg
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Publication number: 20160324608Abstract: A dental solution dispenser includes a body having a first end, a second end, and including a front housing at the first end, a twist back at the second end, and a grip that interposes the front housing and the twist back. An applicator tip is coupled to the body at the first end, and an ampoule assembly is positioned within the body and includes an ampoule sealed at one end with a frangible seal and defining a fluid chamber for storing a dental solution. A mandrel extends longitudinally within the body and provides a piercing member. The twist back is rotatable relative to the grip to pierce the frangible seal with the piercing member. A trigger is coupled to the body and pivotable between an engaged position, where the trigger engages the ampoule assembly, and a disengaged position, where the trigger disengages the ampoule assembly.Type: ApplicationFiled: May 6, 2016Publication date: November 10, 2016Applicant: Young Microbrush, LLCInventors: John Frymark, Todd Korup, Donald Melnikoff, Michael Nix, Robert E. Kreutzer, JR., Richard Gaggioli, Wayne Siebrecht, Scott Rote, Aaron B. Eiger, Nathan Wicker, Kent Solberg
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Patent number: 8192990Abstract: A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1?1 magnesium ions (Mg2+), the buffer solution having a buffer capacity of at least 20 mmol×1?1 ×pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol×1?1. An electric voltage is applied to the suspension.Type: GrantFiled: January 19, 2011Date of Patent: June 5, 2012Assignee: Lonza Cologne GmbHInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
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Patent number: 8039259Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce the biologically active molecules into the cells using electric current. The buffer solution includes at least one of sodium succinate, mannitol and sodium lactobionate. The buffer solution has a buffer capacity of at least 20 mmol*l?1*pH?1 at a change in the from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol * l?1.Type: GrantFiled: October 31, 2007Date of Patent: October 18, 2011Assignee: Lonza Cologne GmbHInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
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Patent number: 8003389Abstract: A method for introducing biologically active molecules into animal or human cells using electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution which has a buffer capacity of at least 20 mmol×l?1×pH?1 and an ionic strength of at least 200 mmol×l?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C. to form a suspension. The method further includes applying an electric voltage to the suspension so as to introduce the biologically active molecules into animal or human cells.Type: GrantFiled: November 9, 2006Date of Patent: August 23, 2011Assignee: Lonza Cologne GmbHInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
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Publication number: 20110117654Abstract: A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1?1 magnesium ions (Mg2+), the buffer solution having a buffer capacity of at least 20 mmol×1?1×pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol×1?1. An electric voltage is applied to the suspension.Type: ApplicationFiled: January 19, 2011Publication date: May 19, 2011Applicant: LONZA COLOGNE AGInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Mueller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhaus, Michael Nix
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Publication number: 20080145938Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce the biologically active molecules into the cells using electric current. The buffer solution includes HEPES and at least 10 mmol*1?1 magnesium ions (Mg2+). The buffer solution has a buffer capacity of at least 20 mmol*1?1*pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C. The buffer solution also has an ionic strength of at least 200 mmol*1?1.Type: ApplicationFiled: October 31, 2007Publication date: June 19, 2008Applicant: AMAXA AGInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
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Publication number: 20080113436Abstract: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using electric current. The buffer solution includes at least one of sodium succinate, mannitol and sodium lactobionate. The buffer solution has a buffer capacity of at least 20 mmol*l?1*pH?1 at a change in the pH from pH 7 to pH 8 and at a temperature of 25° C., and an ionic strength of at least 200 mmol*l?1.Type: ApplicationFiled: October 31, 2007Publication date: May 15, 2008Applicant: amaxa AGInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
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Patent number: 7332332Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce biologically active molecules into cells using an electric current. The inventive buffer solution has a buffering capacity of at least 20 mmol?1×pH?1 and an ionic strength of at least 200 mmol×1?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25° C. The use of a buffer solution of this type allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in the buffer solution.Type: GrantFiled: April 23, 2002Date of Patent: February 19, 2008Assignee: Amaxa AGInventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Müller-Hartmann, Kirsten Rothmann, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
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Publication number: 20070110736Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using an electric current and to a method for introducing biologically active molecules into animal or human cells using an electric current and a buffer solution. The inventive buffer solution has a buffering capacity of at least 20 mmol*I?1*pH?1 and an ionic strength of at least 200 mmol* I?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25 ° C. The use of a buffer solution of this type in the corresponding method allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in said buffer solution.Type: ApplicationFiled: November 9, 2006Publication date: May 17, 2007Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterhus, Michael Nix
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Publication number: 20050064596Abstract: The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using an electric current and to a method for introducing biologically active molecules into animal or human cells using an electric current and a buffer solution. The inventive buffer solution has a buffering capacity of at least 20 mmol*I?1*pH?1 and an ionic strength of at least 200 mmol*I?1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25° C. The use of a buffer solution of this type in the corresponding method allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in said buffer solution.Type: ApplicationFiled: April 23, 2002Publication date: March 24, 2005Inventors: Gudula Riemen, Elke Lorbach, Juliana Helfrich, Gregor Siebenkotten, Herbert Muller-Hartmann, Kirsten Rothmann-Cosic, Corinna Thiel, Meike Weigel, Heike Wessendorf, Helmut Brosterbus, Michael Nix
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Patent number: 5020025Abstract: A read-only memory for storing a plurality of bits of information. The read-only memory includes a plurality of memory cells arranged in an array with each memory cell including a capacitor having either a relatively high capacitance or a relatively low capacitance representing a bit of stored information. The read-only memory further includes a reading means for accessing each memory cell and providing a first or second output responsive to the capacitance level of the memory cell capacitance means.Type: GrantFiled: January 9, 1990Date of Patent: May 28, 1991Assignee: Advanced Micro Devices, Inc.Inventors: Michael Nix, Clayton D. English
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Patent number: D766941Type: GrantFiled: August 17, 2015Date of Patent: September 20, 2016Assignee: TD Ameritrade IP Company, Inc.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D781912Type: GrantFiled: March 31, 2016Date of Patent: March 21, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D786301Type: GrantFiled: September 30, 2016Date of Patent: May 9, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D786302Type: GrantFiled: September 30, 2016Date of Patent: May 9, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D786303Type: GrantFiled: September 30, 2016Date of Patent: May 9, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D786923Type: GrantFiled: September 30, 2016Date of Patent: May 16, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D787552Type: GrantFiled: September 30, 2016Date of Patent: May 23, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Harrison W. Napper, Enrique Sallent, Michael Nix
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Patent number: D788121Type: GrantFiled: September 22, 2015Date of Patent: May 30, 2017Assignee: TD AMERITRADE IP COMPANY, INC.Inventors: Enrique Sallent, Michael Nix