Abstract: A recoil device is provided for a gun having a barrel with a breech. The device includes a breech nut, a brake assembly, a pneumatic spring and a counter-recoil buffer. The breech nut has first and second adjacent sides. The brake assembly includes a brake cylinder that mounts to the breech nut on the first side. The pneumatic spring mounts to the breech nut on the second side. The counter-recoil buffer attaches to the pneumatic spring. The brake cylinder and the pneumatic spring internally push fluids for recoil absorption and return in response to firing the gun.

Abstract: Surgical constructs, assemblies, kits and methods of tissue fixation are disclosed. A suture passing instrument includes a curved tip integral with a distal end of a shaft, a hand assembly mounted on a proximal end of the shaft, and a flexible strand attached to one or two needles and loaded through a cannulation of the shaft. The curve-shaped tip is adapted to engage dural tissue during repairs of the dura mater. The suture passing instrument can grasp and manipulate dura mater and can allow multiple suture passes through the dura mater without removal of the instrument from the durotomy site. The suture passing instrument is provided with a safety mechanism that prohibits the needle(s) to be fired into nerves, providing a safe, reliable, inexpensive, and speedy repair of a durotomy.

Abstract: Described herein are non-natural olivetolic acid cyclases (OAC) variants capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate at a greater rate than a wild type or control OAC. The non-natural OAC (and OLS) can be expressed in an engineered cell having a pathway to form cannabinoids, which include CBGA, its analogs and derivatives. CBGA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.

Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).

Abstract: Described herein are prenyltransferases including non-natural variants thereof having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferases and that are capable of at least two-fold greater rate of formation of cannabinoids such as cannabigerolic acid, cannabigerovarinic acid, cannabigerorcinic acid, and cannabigerol, as compared to a wild type control. Prenyltransferase variants also demonstrated regioselectivity to desired cannabinoid isomers such as CDBA (3-GOLA), 3-GDVA, 3-GOSA, and CBG (2-GOL). The prenyltransferase variants can be used to form prenylated aromatic compounds, and can be expressed in an engineered microbe having a pathway to such compounds, which include 3-GOLA, 3-GDVA, 3-GOSA, and CBG. 3-GOLA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.

Abstract: A drug delivery device comprises an outer surface and a region for receiving a medicament container. The region has an inner surface to contact and support a medicament container received therein. The device also includes a thermal bridge extending between the inner surface and the outer surface to conduct heat between the inner surface and the outer surface. The thermal bridge has a thermal conductivity equal to or greater than 10W/mk.

Abstract: An adjustable arm support for a surgical robotic system, the arm support comprising: a fixed armrest portion that is fixedly coupled to a console seat of the surgical robotic system; and an adjustable armrest portion that is adjustably coupled to the fixed armrest portion, the adjustable armrest portion.

Abstract: This disclosure relates to features of an injection device arranged to provide a sensory distraction to a user during insertion of a needle into flesh. According to a first aspect, an injector device includes a housing having a proximal end and a distal end, and configured to receive a container of medicament, a needle housing for holding a needle in a position at the distal end of the housing, and a needle sleeve mounted within the housing, wherein the needle sleeve and needle housing are moveable relative to one another by a user action between a first configuration in which the needle sleeve would enclose a needle, and a second configuration in which a needle would extend from the needle sleeve in the distal direction, wherein the needle sleeve comprises a portion configured to vibrate and/or rotate during motion between the first configuration and the second configuration.

Abstract: An injection device includes a needle, a needle sleeve surrounding the needle, the needle sleeve having an aperture and being arranged such that the needle extends through the aperture during an injection process, and a needle obscuring element movable between a first position and a second position relative to the needle sleeve. The needle obscuring element is coupled to the needle sleeve when in the first position and when in the second position. The needle obscuring element is arranged to cover a larger portion of the aperture when in the second position than when in the first position.

Abstract: Described herein are prenyltransferases including non-natural variants thereof having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferases and that are capable of at least two-fold greater rate of formation of cannabinoids such as cannabigerolic acid, cannabigerovarinic acid, cannabigerorcinic acid, and cannabigerol, as compared to a wild type control. Prenyltransferase variants also demonstrated regioselectivity to desired cannabinoid isomers such as CDBA (3-GOLA), 3-GDVA, 3-GOSA, and CBG (2-GOL). The prenyltransferase variants can be used to form prenylated aromatic compounds, and can be expressed in an engineered microbe having a pathway to such compounds, which include 3-GOLA, 3-GDVA, 3-GOSA, and CBG. 3-GOLA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.

Abstract: Surgical robotic systems including a user console for controlling a robotic arm or a surgical robotic tool are described. The user console includes components designed to automatically adapt to anthropometric characteristics of a user. A processor of the surgical robotic system is configured to receive anthropometric inputs corresponding to the anthropometric characteristics and to generate an initial console configuration of the user console based on the inputs using a machine learning model. Actuators automatically adjust a seat, a display, or one or more pedals of the user console to the initial console configuration. The initial console configuration establishes a comfortable relative position between the user and the console components. Other embodiments are described and claimed.

Abstract: An injector device comprising an elongate housing having a proximal end and a distal end, and configured to receive a container of medicament, a plunger rod moveable longitudinally within the housing between a primed position and a completed position, the plunger rod being configured to engage a container of medicament when received in the housing; wherein the housing comprises an indicator located in a proximal region of the housing; the indicator comprising a spindle, the spindle comprising a shaft and a dial, and wherein the shaft of the spindle comprises a threaded arrangement configured to engage with a threaded arrangement on the plunger rod such that longitudinal movement of the plunger rod from the primed position towards the completed position is configured to cause the dial of the spindle to rotate to provide a user with information associated with the progress of the injection process dependent upon the longitudinal position of the plunger rod.

Abstract: An injection device storage container includes a case configured to contain at least one injection device for delivering a medicament; and a hanger arrangement coupled to the case and configured to suspend the case from a supporting wall; wherein the case includes an upper panel having an opening formed therein through which the at least one injection device can be dispensed, and wherein the opening is arranged such that, when the case is suspended from the supporting wall, the at least one injection device is dispensed in a horizontal orientation through the opening.

Abstract: A patch for placement on the skin and for use with an injector device. The patch comprises a first layer on a first side of the patch, a second layer on a second side of the patch opposite to the first side, and a sealed fluid reservoir between the first and second layers. A fluid is contained within the fluid reservoir. The patch also includes a moveable rupturing element and an aperture. The rupturing element is configured to rupture the fluid reservoir to allow release of the fluid out of the fluid reservoir. The aperture extends at least partially through the patch to receive an injection needle of an injector device. Also provided is a system comprising an injector device and such a patch, and also a method of use of such a patch.

Abstract: A user system for a robotic surgical system, the user system including a handheld groundless user interface device configured to control the robotic surgical system, and a user console. The user console includes a seat and a first adjustable, ergonomic arm support linkage coupled to the seat, in which the first arm support linkage is movable between a folded storage configuration and at least one unfolded use configuration corresponding to at least one of a user characteristic and a surgical task characteristic. The at least one unfolded use configuration may be pre-stored in a database.

Abstract: The present invention features microbiological nutrient media capable of supporting growth of microorganisms. The medium includes a gelling agent and a dye and/or pigment that reduces background.

Abstract: An injector device comprising an elongate housing having a proximal end and a distal end, and configured to receive a container of medicament, a plunger rod moveable longitudinally within the housing between a primed position and a completed position, the plunger rod being configured to be engageable with a container of medicament. The housing comprises an indicator located in a proximal region of the housing. The indicator comprises a display window located in the proximal region of a side wall of the housing, a projection proximally extending from the plunger rod. The projection is coupled to the plunger rod and is visible through the display window in the primed position. The projection is configured to move between a first indicating position and a second indicating position to provide a user with information associated with a progress of an injection process dependent upon the longitudinal position of the plunger rod.

Abstract: An injector device comprising: an outer housing for receiving a medicament container; and a drive mechanism for dispensing medicament from a medicament container received in the outer housing. The drive mechanism comprises a plunger rod and a displacing member configured to displace a distal end of the plunger rod into said medicament container to dispense said medicament. The device further comprises a brake configured to slow the rate of displacement of the plunger rod under the force of the displacing member.

Abstract: Transdermal drug delivery devices are described herein such as a microneedle array patch, to be placed on the skin for transdermal delivery of a medicament. The transdermal drug delivery device for delivery of a bioactive agent through mammalian skin comprises an array of microneedles and a means to actuate the microneedles, wherein the actuation means actuates the microneedles separately.

Abstract: Surgical robotic systems including a user console for controlling a robotic arm or a surgical robotic tool are described. The user console includes components designed to automatically adapt to anthropometric characteristics of a user. A processor of the surgical robotic system is configured to receive anthropometric inputs corresponding to the anthropometric characteristics and to generate an initial console configuration of the user console based on the inputs using a machine learning model. Actuators automatically adjust a seat, a display, or one or more pedals of the user console to the initial console configuration. The initial console configuration establishes a comfortable relative position between the user and the console components. Other embodiments are described and claimed.