Abstract: A storage and drinking container for pressurised beverages comprises a drinking vessel (1) having a lip (3) and a lid formed from a cap (5) and retaining ring (12). The cap (5) seals with a sealing surface (4) on the inside of the neck of the drinking vessel and is retained in place by fingers (8) engaging under a lip (3). The fingers 8 are retained in position by a retaining ring (12). Cooperating sets of cammed surfaces (10) and (13) on the cap (5) and retaining ring (12) act on rotation of the retaining ring to axially separate the retaining ring (12) from the cap (5), releasing the fingers 8 from under the lip (3) and permitting the lid to be removed. The invention provides a drinking vessel with a wide neck which can be reliably sealed without the necessity to provide screw threads on the outer surface of the drinking vessel (1).

Abstract: A device for applying controlled unitized doses of a flowable material to a surface is disclosed. The device includes a tubular body and a plunger. The body has a wall defining a cavity, and the body has a first open end and an opposite second end having a dispensing orifice. A flowable material is contained in the cavity of the body. The plunger has an outer sleeve dimensioned for surrounding at least a section the body and an inner pushing structure dimensioned for axial movement in the cavity of the body. The device has means for indexed positioning of the second end of the body and an inner end of the inner pushing structure of the plunger relative to each other to provide controlled unitized doses of the flowable material to a surface when the plunger is moved toward the body by a user's hand.

Abstract: Systems and methods for use with an optical communication beam are disclosed. The system allows the beam of light to operate at an adequate power level that provides a robust optical link while minimizing any safety risk to humans. The system calibrates and controls the gain for an avalanche photodiode detector (APD). A detector circuit is used to calibrate the APD. Once calibrated, the detector circuit further provides an electrical bias to the APD to process or condition the electrical signal to produce a detector output. The systems and methods disclosed herein attenuate the power level of an incoming communication beam to prevent oversaturation of an APD. The system further provides an alignment signal, which is effective over a wide dynamic range of incoming power levels.

Abstract: This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, S, T, U, V, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions and methods of treating diseases.

Abstract: A wireless subscriber communication unit comprises a transmitter having a power amplifier and a feedback power control loop having a power control function arranged to set an output power level of the power amplifier. The power control function is arranged to perform a back-off of the output power prior to completion of a transmission burst.

Abstract: Systems and methods for use with an optical communication beam are disclosed. The system allows the beam of light to operate at an adequate power level that provides a robust optical link while minimizing any safety risk to humans. The system calibrates and controls the gain for an avalanche photodiode detector (APD). A detector circuit is used to calibrate the APD. Once calibrated, the detector circuit further provides an electrical bias to the APD to process or condition the electrical signal to produce a detector output. The systems and methods disclosed herein attenuate the power level of an incoming communication beam to prevent oversaturation of an APD. The system further provides an alignment signal, which is effective over a wide dynamic range of incoming power levels.

Abstract: A molding composition suitable for encapsulating solid state devices includes an epoxy resin, a hardener, a poly(arylene ether) resin comprising less than 5 weight percent of particles greater than 100 micrometers, and about 70 to about 95 weight percent of a silica filler, based on the total weight of the composition. After curing, the composition exhibits improved increased copper adhesion and reduced shrinkage compared to conventional molding compositions.

Abstract: Methods and devices for reducing costs associated with life settlement transactions include an initial economic evaluation and a targeted but abbreviated verification of information provided by a potential customer and gathering of additional information, followed by a conditional offer for those policies that satisfy the economic criteria (e.g., face value of policy, stated life expectancy, etc.) and for which the abbreviated verification is positive. The verification and additional information may be performed by one or more of following: 1) a query of a prescription database in which the identity and use of the prescription drugs identified by the customer are determined; 2) a questionnaire filled out by a physician treating the patient for a particular illness; and 3) a telephone inquiry of the insured. If the additional information and verification are consistent with the initial information, the life settlement is completed.

Abstract: This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R1, Q, W1, W2, W2a, R3a, R3b, L1, and L2, the pharmaceutical composition, the method of treating, and the therapeutic combination are as defined in the specification.

Abstract: A curable method useful for encapsulating solid state devices includes (A) an epoxy resin; (B) an effective amount of a cure catalyst comprising (B1) a first latent cationic cure catalyst comprising a diaryl iodonium hexafluoroantimonate salt; (B2) a second latent cationic cure catalyst comprising (B2a) a diaryl iodonium cation, and (B2b) an anion selected from perchlorate, imidodisulfurylfluoride anion, unsubstituted and substituted (C1-C12)-hydrocarbylsulfonates, (C2-C12)-perfluoroalkanoates, tetrafluoroborate, unsubstituted and substituted tetra-(C1-C12)-hydrocarbylborates, hexafluorophosphate, hexafluoroarsenate, tris(trifluoromethylsulfonyl)methyl anion, bis(trifluoromethylsulfonyl)methyl anion, bis(trifluoromethylsulfuryl)imide anion, and combinations thereof; and (B3) a cure co-catalyst selected from free-radical generating aromatic compounds, peroxy compounds, copper (II) salts of aliphatic carboxylic acids, copper (II) salts of aromatic carboxylic acids, copper (II) acetylacetonate, and combinations

Abstract: A graft and method of using a graft are described that should decrease the incidence of abnormal placentation and uterine rupture that result from cesarean section and restore the anatomic integrity of the uterus at a hysterotomy surgical site, while not disturbing the involution of the postpartum uterus.

Abstract: Articles for applying color on a surface comprise a sheet of dry color component and an adhesive on one surface of the sheet of dry color component. The article further includes a releasable liner, and the sheet of dry color component is arranged between the releasable liner and the adhesive. Methods for providing a substantially permanent color effect on an architectural surface comprise delivering such an article to the architectural surface.

Abstract: Apparatuses, methods, and systems associated with traction devices for vehicle tires are disclosed herein. In various embodiments, a tire may include a tread material bonded with a casing, the tread material having a tread pattern and one or more tractive devices may be disposed within voids in the tread pattern. In some embodiments, a media passage may be disposed between the tread material and the casing substantially under one or more of the voids in the tread pattern, the chambers and/or channels being controllable to urge movement of a corresponding tractive device.

Abstract: A curable composition includes an olefinically unsaturated monomer and a poly(arylene ether) having two polymerizable groups and an intrinsic viscosity of about 0.05 to about 0.30 deciliters per gram. The composition exhibits an improved combination of high flow during molding and high post-cure stiffness and impact strength. The composition is particularly useful for fabricating plastic-packaged electronic devices.

Abstract: Many computing system environments require continuous availability and high operational readiness. The ability to find, diagnose, and correct actual faults and potential faults in these systems is a high priority. By combining a continually updated database of computing system performance with the ability to analyze that information to detect faults and then communicating that fault information to correct the fault or provide appropriate notification of the fault results in achieving the goals of high availability and operational readiness. FIG. (1) shows how the data collectors, fault detectors and policy actions are combined to meet those goals.

Abstract: A brew stick for brewing a measure of brewable material. The brew stick may include a bag with the measure of brewable material positioned therein and a plate. The plate may include a pair of wings and a central tab. The bag is connected to the central tab such that the bag can be raised within the wings.

Abstract: The invention provides compounds of the formula (I); or salts or solvates or N-oxides thereof; wherein: Rq is selected from groups (a), (b) and (c); the asterisk denoting the point of attachment to the pyrazole ring; X is N or CR5; X? is NR4; O, S or S(O); A is a bond or —(CH2)m—(B)n—; B is C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; m is 0, 1 or 2; n is 0 or 1; R0 is hydrogen or, together with NRg when present, forms a group —(CH2)p— wherein p is 2 to 4; and R1 to R6b are as defined in the description. Compounds of the formula (I) have activity as inhibitors of CDK, aurora and GSK-3 kinases are useful in treating or preventing diseases such as cancers that are mediated by the said kinases.

Abstract: A freestanding dispenser for dual dispensing of a wet substrate and a dry substrate includes: a base for supporting the freestanding dispenser on a substantially horizontal surface; a support member connected to the base, the support member holding a roll of a dry substrate in a substantially vertical position; and a source of a wet substrate supported by the freestanding dispenser.

Abstract: The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

Abstract: Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.