Abstract: A reagent cuvette has a first chamber with an inspection part and a socket, and a second chamber. The socket has four spikes at its base. Both chambers are sealed with a membrane. At the point-of-care the foil membrane of the first chamber is peeled away by the therapist (typically general practitioner doctor). A sample, such as blood, is added to the chamber using a pipette or other device to provide a verifiable quantity of sample. This provides a mixture of a buffer reagent supplied in the chamber and the sample injected into the inspection chamber at the point of care. The chamber is then inserted into the socket by gently pressing it down so that its foil membrane is broken by the spikes. This causes the starter reagent to drop down from within the second chamber into the inspection part of the first chamber. The inspection part is then inserted into an optical inspection instrument for analysis of the two reagents and the sample mixed together.

Abstract: An integrated fuse device (1) includes a varistor stack (11), a thermal fuse (12), and a current fuse (13) within an enclosure (2) having device terminals (3). The varistor stack (11) is connected to the thermal fuse (12) by a Cu terminal (20) and is connected to the device terminal (3) by steel terminal (10) of smaller cross-sectional area. Being of Cu material and having a greater cross-sectional area, the terminal (20) connected to the thermal fuse (12) has greater thermal conductivity than the steel terminal (10) to the end cap (3). The thermal fuse (12) comprises a plurality of links having a melting point to melt with sustained overvoltage, the links having a diameter in the range of about 2 mm to about 3 mm. The links pass through an elastomer plug (15), which exerts physical pressure on them to assist with opening during sustained overvoltage. Hot melt (18) around solder (17) of the thermal fuse limits heat conduction to back-fill sand.

Abstract: An integrated fuse device (1) includes a varistor stack (11), a thermal fuse (12), and a current fuse (13) within an enclosure (2) having device terminals (3). The varistor stack (11) is connected to the thermal fuse (12) by a Cu terminal (20) and is connected to the device terminal (3) by steel terminal (10) of smaller cross-sectional area. Being of Cu material and having a greater cross-sectional area, the terminal (20) connected to the thermal fuse (12) has greater thermal conductivity than the steel terminal (10) to the end cap (3). The thermal fuse (12) comprises a plurality of links having a melting point to melt with sustained overvoltage, the links having a diameter in the range of about 2 mm to about 3 mm. The links pass through an elastomer plug (15), which exerts physical pressure on them to assist with opening during sustained overvoltage. Hot melt (18) around solder (17) of the thermal fuse limits heat conduction to back-fill sand.

Abstract: The invention relates to variants of the ADAM12 gene and the role these variants have to play in the diagnosis and treatment of a number of conditions including cancer, disorders of myogenesis, adipogenesis, cardiac hypertrophy and Alzheimer's disease, and in particular, Late Onset Alzheimer's Disease.

Abstract: A reagent cuvette (1) has a first chamber (2) with an inspection part (5) and a socket (6), and a second chamber (3). The socket (6) has four spikes (20) at its base. Both chambers are sealed with a membrane. At the point-of-care the foil membrane (7) of the first chamber (2) is peeled away by the therapist (typically general practitioner doctor). A sample, such as blood, is added to the chamber (2) using a pipette or other device to provide a verifiable quantity of sample. This provides a mixture of a buffer reagent supplied in the chamber (2) and the sample injected into the inspection chamber 2 at the point of care. The chamber (3) is then inserted into the socket (6) by gently pressing it down so that its foil membrane is broken by the spikes (20). This causes the starter reagent to drop down from within the second chamber (3) into the inspection part (5) of the first chamber (2).

Abstract: A varistor has a thermal fuse between a lead and an electrode. The fuse includes a link extending between the surface of an insulator and the fused electrode. The electrical connection of the link and the electrode is maintained by a low temperature solder fillet. That part of the link between the electrode and the insulator is surrounded by hot melt electrically insulating material. Upon sustained over-voltage conditions, the link and the solder fillet melt, and an insulating gap is rapidly created by molten hot melt material.

Abstract: A varistor has a thermal fuse between a lead and an electrode. The fuse includes a link extending between the surface of an insulator and the fused electrode. The electrical connection of the link and the electrode is maintained by a low temperature solder fillet. That part of the link between the electrode and the insulator is surrounded by hot melt electrically insulating material. Upon sustained over-voltage conditions, the link and the solder fillet melt, and an insulating gap is rapidly created by molten hot melt material.