Abstract: Provided is an effective amount of a desialylation agent and an effective amount of an anti CD38 antibody for use in the treatment of multiple myeloma. This results in potentiated primary NK cell activity against the multiple myeloma cell. Also envisaged is a method of treating multiple myeloma in a subject in need thereof.

Abstract: The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.

Abstract: A method of treating cancer is provided wherein the method comprises inhibiting or reducing sialylation of specifically Mesenchymal Stromal Cells (MSCs) to inhibit MSC immunosuppression and restore T cell proliferation in cancer. The method may comprise administering a sialyltransferase inhibitor (e.g. 3Fax-Peracetyl Neu5Ac) or sialidase. Also described is administration of MSCs which have been manipulated prior to administration to remove sialic acids and use of a small molecule or blocking antibody which blocks interactions between MSC-sialic acid and lectins, such as Siglec 7, and/or blocks interactions between MSC-lectins and sialic acid.

Abstract: NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

Abstract: NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

Abstract: NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

Abstract: NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

Abstract: Provided are combination therapies comprising an anti-CD38 antibody and cyclophosphamide for CD38-positive hematological malignancies.

Abstract: The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.

Abstract: NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.

Abstract: Projectiles with sealed propellant are described herein. In one embodiment of the invention, a projectile includes a body having a nose portion and a tail portion, a plurality of propellant charges contained within the body, a plurality of selectable initiators contained within the body for ignition of respective propellant charges, one or more ports for exit of ignition gases produced by the charges for propulsion of the projectile from the weapon, and one or more inductors for inducing a firing current, where at least one initiator only initiates on receiving a firing current which is different from the firing signal required to initiate the other initiators.

Abstract: Projectiles with sealed propellant are described herein. In one embodiment of the invention, a projectile includes a body having a nose portion and a tail portion, a plurality of propellant charges contained within the body, a plurality of selectable initiators contained within the body for ignition of respective propellant charges, one or more ports for exit of ignition gases produced by the charges for propulsion of the projectile from the weapon, and one or more inductors for inducing a firing current, where at least one initiator only initiates on receiving a firing current which is different from the firing signal required to initiate the other initiators.

Abstract: The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.

Abstract: Projectiles with sealed propellant are described herein. In one embodiment of the invention, a projectile includes a body having a nose portion and a tail portion, a plurality of propellant charges contained within the body, a plurality of selectable initiators contained within the body for ignition of respective propellant charges, one or more ports for exit of ignition gases produced by the charges for propulsion of the projectile from the weapon, and one or more inductors for inducing a firing current, where at least one initiator only initiates on receiving a firing current which is different from the firing signal required to initiate the other initiators.

Abstract: Projectiles with sealed propellant are described herein. In one embodiment of the invention, a projectile includes a chamber having a propellant charger, an exit from the chamber for release of propellant gases into a barrel when the propellant is ignited to fire the projectile, and a seal to block the exit which is opened by ignition of the propellant within the chamber but is resistant to ignition of other propellant in the barrel, where the seal is carried from the barrel by the projectile after the ignition. Other methods and apparatuses are also described.

Abstract: A barrel assembly for a weapon, said barrel assembly including a barrel; a plurality of projectile assemblies axially disposed in end to end abutting relationship within said barrel for operative sealing engagement with the bore of the barrel, each projectile including a projectile head and an integral cylindrical spacer portion extending axially and rearwardly from said projectile head; discrete propellant charges accommodated within said cylindrical spacer portion for propelling respective projectile assemblies sequentially through the muzzle of the barrel; ignition means for igniting said discrete propellant charges; and control means for selectively and sequentially actuating the ignition means.

Abstract: An existing projectile (21) is modified by adding a tail piece (22) to enable axial stacking of multiple projectiles (20) in a common barrel. Propellant for each modified projectile (20) is contained in respective chambers located external to the barrel and connected to the bore of the barrel through associated ports. Tail piece (22) aligns with a respective port and provides a space between consecutive projectiles (20) into which the propellant gas expands after ignition. Separate claims are directed to tail assembly (22), modified projectile (20), the barrel assembly having a plurality of projectiles (20) stacked in end-to-end relation, and to an external initiation system for the barrel assembly (see FIGS. 4, 7).

Abstract: A projectile (10) is for use with barrel assemblies of the type having a plurality of projectiles axially disposed within a barrel having a bore and a muzzle and which projectiles are associated with discrete propellant charges for propelling said projectiles sequentially through the muzzle of the barrel. Projectile (10) comprises expandable sleeve (11) encircling at least part of core (12). Sleeve (11) and core (12) have wedging surfaces (14) operable to deform trailing part (21) of sleeve (11) into sealing engagement with the bore in response to pressure exerted on the projectile (10). When projectiles (10) are axially disposed in the bore, rear face (24) of the leading projectile cooperates with leading face (20) of the trailing projectile to define a discrete space about spine (23) for receipt of the propellant charge. Sleeve (11) is retained about the core (12) during travel to the target.

Abstract: A weapon (104) including a stock, a barrel assembly (105) slidably mounted on said stock whereby, on discharging said weapon, the barrel assembly (105) slidably recoils relative to said stock, and a damper (107) for decelerating the recoiling barrel assembly, wherein said barrel assembly (105) includes a plurality of projectiles axially disposed within a barrel (108) wherein each of said projectiles is associated with a discrete propellant charge for propelling said projectile from the barrel. Suitably the weapon further includes a breech block (109) which slidably recoils relative to said stock and a further damper (106) for decelerating the recoiling breech block.

Abstract: A projectile (10) is for use with barrel assemblies of the type having a plurality of projectiles axially disposed within a barrel having a bore and a muzzle and which projectiles are associated with discrete propellant charges for propelling said projectiles sequentially through the muzzle of the barrel. Projectile (10) comprises expandable sleeve (11) encircling at least part of core (12). Sleeve (11) and core (12) have wedging surfaces (14) operable to deform trailing part (21) of sleeve (11) into sealing engagement with the bore in response to pressure exerted on the projectile (10). When projectiles (10) are axially disposed in the bore, rear face (24) of the leading projectile cooperates with leading face (20) of the trailing projectile to define a discrete space about spine (23) for receipt of the propellant charge. Sleeve (11) is retained about the core (12) during travel to the target.