Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A system for recording HIPAA compliant medical imagery may be configured as follows. A medical imaging system comprising a special purpose computer. The special purpose computer comprising: a processor, a permanently installed hard drive, and a random access memory. The permanently installed hard drive is configured such that it stores all instructions necessary for the processor to process medical files transmitted from the first medical system. The permanently installed hard drive is further configured such that it stores all instructions necessary for the processor to encrypt and store all medical files, as they are created, on a removable drive only. The removable drive is an encrypted removable flash storage drive.

Abstract: A diffraction grating may include a substrate. The diffraction grating may include an etch stop layer to prevent etching of the substrate. The etch stop layer may be deposited on the substrate. The diffraction grating may include a marker layer to indicate an etch end-point associated with etching of a dielectric layer. The marker layer may be deposited on a portion of the etch stop layer. The diffraction grating may include the dielectric layer to form a grating layer after being etched. The dielectric layer may be deposited on at least the marker layer.

Abstract: Improved personal protective equipment facial wear including, in one embodiment, an at least partly adhesive mask, and one or more adhesive eye shields. In one implementation, the mask avoids significant contact with the delicate periorbital skin of the wearer, yet provides a substantially airtight seal so as to preclude moisture vapor transfer and “fogging” of eyeware or instruments. In another implementation, adherence of the eye shield is at least partially overlapping with the mask and creates an at least partial seal around a perimeter of the eye shield. Further, an at least partial seal is formed around a perimeter of the mask. The mask and eye shield additionally prevent nasal air flow obstruction, and address the problem of skin irritation and attachment during normal facial expression and movement of the wearer.

Abstract: A system for recording HIPAA compliant medical imagery may be configured as follows. A medical imaging system comprising a special purpose computer. The special purpose computer comprising: a processor, a permanently installed hard drive, and a random access memory. The permanently installed hard drive is configured such that it stores all instructions necessary for the processor to process medical files transmitted from the first medical system. The permanently installed hard drive is further configured such that it stores all instructions necessary for the processor to encrypt and store all medical files, as they are created, on a removable drive only. The removable drive is an encrypted removable flash storage drive.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A system for recording HIPAA compliant medical imagery may be configured using two separate systems. A first system comprising a separate and independent medical imaging device such as a microscope, an endoscope, or a similar medical imaging tool. The desired medical imaging tool is configured so that a high-definition recording device is able to capture the imagery displayed by the medical imaging tool. The separate and independent medical imaging device is further configured to transmit the high-definition captured imagery to a second separate and independent medical imagery processing system. The second separate and independent medical imagery processing system may be configured to include a special purpose computer with a processor, a hard drive, a random-access memory, and a removable encrypted flash drive. The processor may be configured, using well understood techniques, to process the high-definition imagery that is transmitted from the separate and independent medical imaging device.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A diffraction grating may include a substrate. The diffraction grating may include an etch stop layer to prevent etching of the substrate. The etch stop layer may be deposited on the substrate. The diffraction grating may include a marker layer to indicate an etch end-point associated with etching of a dielectric layer. The marker layer may be deposited on a portion of the etch stop layer. The diffraction grating may include the dielectric layer to form a grating layer after being etched. The dielectric layer may be deposited on at least the marker layer.

Abstract: A diffraction grating may include a substrate. The diffraction grating may include an etch stop layer to prevent etching of the substrate. The etch stop layer may be deposited on the substrate. The diffraction grating may include a marker layer to indicate an etch end-point associated with etching of a dielectric layer. The marker layer may be deposited on a portion of the etch stop layer. The diffraction grating may include the dielectric layer to form a grating layer after being etched. The dielectric layer may be deposited on at least the marker layer.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A diffraction grating may include a substrate. The diffraction grating may include an etch stop layer to prevent etching of the substrate. The etch stop layer may be deposited on the substrate. The diffraction grating may include a marker layer to indicate an etch end-point associated with etching of a dielectric layer. The marker layer may be deposited on a portion of the etch stop layer. The diffraction grating may include the dielectric layer to form a grating layer after being etched. The dielectric layer may be deposited on at least the marker layer.

Abstract: A system for recording HIPAA compliant medical imagery may be configured using two separate systems. A first system comprising a separate and independent medical imaging device such as a microscope, an endoscope, or a similar medical imaging tool. The desired medical imaging tool is configured so that a high-definition recording device is able to capture the imagery displayed by the medical imaging tool. The separate and independent medical imaging device is further configured to transmit the high-definition captured imagery to a second separate and independent medical imagery processing system. The second separate and independent medical imagery processing system may be configured to include a special purpose computer with a processor, a hard drive, a random-access memory, and a removable encrypted flash drive. The processor may be configured, using well understood techniques, to process the high-definition imagery that is transmitted from the separate and independent medical imaging device.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: Improved personal protective equipment facial wear including, in one embodiment, an at least partly adhesive mask, and one or more adhesive eye shields. In one implementation, the mask avoids significant contact with the delicate periorbital skin of the wearer, yet provides a substantially airtight seal so as to preclude moisture vapor transfer and “fogging” of eyeware or instruments. In another implementation, adherence of the eye shield is at least partially overlapping with the mask and creates an at least partial seal around a perimeter of the eye shield. Further, an at least partial seal is formed around a perimeter of the mask. The mask and eye shield additionally prevent nasal air flow obstruction, and address the problem of skin irritation and attachment during normal facial expression and movement of the wearer.

Abstract: A zoned waveplate has a series of transversely stacked birefringent zones alternating with non-birefringent zones. The birefringent and non-birefringent zones are integrally formed upon an AR-coated face of a single substrate by patterning the AR coated face of the substrate with zero-order sub-wavelength form-birefringent gratings configured to have a target retardance. The layer structure of the AR coating is designed to provide the target birefringence in the patterned zones and the reflection suppression.

Abstract: A system for creating an eye-movement record that is useful for diagnosing balance disorders of a patient includes a head-mounted unit having an indicator which generates head position signals. Also included is a computer/controller for progressing the patient through a sequence of predetermined head orientations. An imaging unit in the head-mounted unit is used to create an eye-movement record for each head orientation, and the records are then archived in a recorder. With instructions from the patient, a de-identified eye-movement record can be sent to selected regional specialists for further evaluation and possible treatment.

Abstract: A system and method for creating and/or presenting electronic forms to users and securely collecting the data entered into the electronic forms. A dashboard application includes a collection of electronic forms for display on a presentation device. Clients complete their corresponding form(s) through the presentation device and the completed form(s) are collected by a server application and stored in a database remote from the presentation device.