Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

Abstract: Devices and methods for bending or cutting implants are disclosed herein. In some embodiments, an instrument can include a rotatable drive shaft that urges first and second portions of a modular bending or cutting template toward one another to bend or cut an implant disposed between the template portions. A linkage assembly can be included to provide a mechanical advantage in urging the template portions toward one another. In some embodiments, an instrument can include a rotatable drive shaft that, depending on direction of rotation, pushes or pulls a first modular template portion with respect to a second modular template portion to bend an implant disposed between the template portions in one direction or another direction. In some embodiments, an instrument can include a worm drive that rotates a cutting wheel with respect to a cutting plate to cut an implant inserted through openings formed in the cutting wheel and the cutting plate.

Abstract: A medical implant may include a structural member and a radiopaque marker. The structural member may include a first surface, a second surface disposed opposite the first surface, an opening extending from the first surface to the second surface and defining a central axis, and a plurality of barbs extending into the opening toward the central axis. The barbs may be spaced apart from one another and spaced apart from each of the first surface and the second surface. The radiopaque marker may be disposed within the opening.

Abstract: A ceiling electrical box can include a housing and a bracket. The housing is defined by a rear wall at a first end, at least one sidewall, and an opening at a second end and includes a first emboss tab, a second emboss tab, a pair of screw holes, a pair of first bores, and a pair of second bores. The bracket includes a first portion, a second portion, a pair of first threaded apertures, and a pair of second threaded apertures. The bracket can include a third portion and a fourth portion extending on a first plane of the first portion. The ceiling electrical box can also include a pair of first fasteners to attach the housing to the bracket and a pair of second fasteners to engage the bracket through the housing, the second fasteners configured to receive a fixture plate for a ceiling fixture.

Abstract: A mold core (and method for making same), for a concrete product mold comprising a mold core wall shaped to extend from a mold surface into an interior of the mold, preventing concrete from filling an area of the mold interior when the mold core is installed on the mold surface, the mold core wall comprising welded-together steel wire.

Abstract: A ceiling electrical box can include a housing and a bracket. The housing is defined by a rear wall at a first end, at least one sidewall, and an opening at a second end and includes a first emboss tab, a second emboss tab, a pair of screw holes, a pair of first bores, and a pair of second bores. The bracket includes a first portion, a second portion, a pair of first threaded apertures, and a pair of second threaded apertures. The bracket can include a third portion and a fourth portion extending on a first plane of the first portion. The ceiling electrical box can also include a pair of first fasteners to attach the housing to the bracket and a pair of second fasteners to engage the bracket through the housing, the second fasteners configured to receive a fixture plate for a ceiling fixture.

Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

Abstract: In one embodiment, an anatomical implant template has a template body having opposed first and second terminal ends. The template body bends so as to change the body from a first configuration, whereby the body extends from the first terminal end to the second terminal end along a first path, to a second configuration, whereby the body extends from the first terminal end to the second terminal end along a second path, different from the first path, the second path conforming more closely to the curvature of the at least one anatomical body. The body supports at least one device that outputs at least one signal from which a shape of the body in the second configuration can be ascertained. The anatomical implant template can further communicate the at least one signal to a computing device that generates signals for bending an anatomical implant.

Abstract: A surgical tool is disclosed. The surgical tool includes a functional tool, a functional tip, at least one sensor, and a control unit. The functional tool has a shaft and a distal end. The functional tip is positioned at the distal end of the housing; at least one sensor is configured to generate a first signal indicative of at least one of an acoustic signal or a vibration signal generated by the functional tool. The control unit receives the first signal, analyzes the first signal to determine tissue type in contact with the functional tip and supplies a second signal to the functional tool to control at least one operation of the functional tool based upon the tissue type in contact with the functional tip.

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I. wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract: Systems and methods are disclosed herein that can allow for wirelessly powering and/or communicating with a sterile-packed electronic device without removing the electronic device from its sterile packaging and while maintaining the sterility of the electronic device. In some embodiments, a base station with a power transmitter wirelessly transfers power to a power receiver of the electronic device, for example using inductive, capacitive, or ultrasonic coupling. The base station or another external device can also be used to wirelessly program or interrogate the electronic device. Battery charging circuits and switching circuits for use with said systems and methods are also disclosed.

Abstract: A pre-assembled, telescoping elongate system comprising an outer elongate member surrounding a finer gauge inner elongate member which, after percutaneous penetration by the outer elongate element, extends to penetrate an intervertebral disc into which a sensing element and/or an injectable may be delivered.

Abstract: A method and apparatus are disclosed. The method includes removably attaching an input device of a surgical feedback system to a surgical tool having a handle. The input device has at least one sensor configured to collect a plurality of original signals. The plurality of original signals has at least one of an acoustic signal or a vibration signal. The surgical tool contacts tissue of a patient. And, a notification of the type of tissue being contacted by the surgical tool is received.

Abstract: An apparatus for inserting implants in a bone comprising a frame having a cartridge receiving chamber and a barrel. A cartridge defining a plurality of chambers is positioned in the cartridge receiving chamber so the chambers are selectively alignable with a longitudinal passage of the barrel. At least one instrument is positioned in one of the chambers, and a plurality of implants is positioned in the other chambers. A drive assembly is engageable with the instrument and the implants. The drive assembly is slidably and rotatably disposed in the frame and is moveable between a retracted position, an engaging position wherein the distal end of the drive assembly is positioned to engage the selected one of the instrument and the implants, and an extended position wherein the drive assembly extends through the chamber to transport the selected one of the instrument or the implant from the chamber to the distal end of the barrel.

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Abstract: The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.

Abstract: A pre-assembled, telescoping needle system comprising an outer needle surrounding a finer gauge needle which, after percutaneous penetration by the outer needle, extends to penetrate the intervertebral disc into which the injectable is to be delivered.

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract: Systems and methods for reducing the risk of PJK, PJF, and other conditions are disclosed herein. In some embodiments, a longitudinal extension can be added to a primary fixation construct to extend the construct to one or more additional vertebral levels. The extension can be attached to a first attachment point, such as a bone anchor implanted in a vertebra that is superior to the primary construct. The extension can also be attached to a second attachment point, such as a component of the primary construct or an anatomical structure disposed inferior to the first attachment point. The extension can be more flexible than the primary construct and/or can limit motion to a lesser degree than the primary construct, thereby providing a more-gradual transition from the instrumented vertebrae to the natural patient anatomy adjacent thereto. The extension can be placed with little or no soft tissue disruption.

Abstract: Systems and methods for reducing the risk of PJK, PJF, and other conditions are disclosed herein. In some embodiments, a longitudinal extension can be added to a primary fixation construct to extend the construct to one or more additional vertebral levels. The extension can be attached to a first attachment point, such as a spinous process of a vertebra that is superior to the primary construct. The extension can also be attached to a second attachment point, such as a component of the primary construct or an anatomical structure disposed inferior to the first attachment point. The extension can be more flexible than the primary construct and/or can limit motion to a lesser degree than the primary construct, thereby providing a more-gradual transition from the instrumented vertebrae to the natural patient anatomy adjacent thereto. The extension can be placed with little or no soft tissue disruption.