Abstract: Certain embodiments involve generating or optimizing a neural network for generating analytical or predictive outputs. The neural network can be generated using a relationship between various predictor variables and an outcome (e.g., a condition's presence or absence). The neural network can be used to determine a relationship between each of the predictor variables and a response variable. The neural network can be optimized by iteratively adjusting the neural network such that a monotonic relationship exists between each of the predictor variables and the response variable. The optimized neural network can be used both for accurately determining response variables using predictor variables and determining adverse action codes for the predictor variables, which indicate an effect or an amount of impact that a given predictor variable has on the response variable.

Abstract: A system for imaging a body lumen includes a controller and a display. The controller is configured to connect to a proximal end of a catheter having an optical fiber extending along the length of an elongate catheter body. The controller is further configured to rotate a distal end of the optical fiber from a location near a proximal end of the elongate catheter body, acquire optical coherence tomography (OCT) images using the optical fiber as the distal end of the optical fiber rotates, and determine a rotational lag of the distal end of the optical fiber. The display is configured to display one or more OCT images corrected for the rotational lag.

Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

Abstract: The present invention relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as tools or as pharmaceuticals as modulators of the N-formyl peptide receptor (FPR), including FPR1 and FPR2, or as selective agonists of the FPR1 receptor.

Abstract: Methods and apparatus for surface profiling and texturing of chamber components for use in a process chamber, such surface-profiled or textured chamber components, and method of use of same are provided herein. In some embodiments, a method includes measuring a parameter of a reference substrate or a heated pedestal using one or more sensors and modifying a surface of a chamber component based on the measured parameter.

Abstract: A barrier having a gate and a frame where each of the frame and gate is reduced in at least one of a height and length dimension so as to be shipped and stored in a box of minimal size.

Abstract: A method for the thermal treatment of bulk materials in a rotary tube with at least one infrared light unit. Bulk material is introduced into the rotary tube, which is provided on its inner wall with at least one mixing element and in the interior space of which the pressure of the ambient atmosphere prevails. A heat treatment of the bulk material is performed by at least one electrical infrared light unit, which is arranged at the center of the rotary tube and the light cone of which is directed onto the bed of bulk material that lies on the inner wall of the rotary tube. The bulk material is discharged from the rotary tube. Water vapor is directed onto the surface of the bulk material. The vapor is introduced into the interior space of the rotary tube through a nozzle tube.

Abstract: Methods, systems, and media for automated compliance determination of content items are provided.

Abstract: Systems, methods, and computer programs for analyzing genetic sequence data is disclosed. In one aspect, the system can include one or more of a first integrated circuit, with each first integrated circuit forming a central processing unit (CPU) that is responsive to one or more software algorithms that are configured to instruct the CPU to perform a first set of genomic processing steps of a sequence analysis pipeline. Additionally, the system can include one or more second integrated circuits, with each second integrated circuit forming a field programmable gate array (FPGA). The FPGA can be configured by firmware to arrange a set of hardwired digital logic circuits to perform a second set of genomic processing stages of the sequence analysis pipeline, the set of hardwired digital logic circuits of each FPGA being arranged as a set of processing engines to perform the second set of genomic processing stages.

Abstract: The invention relates to a magnetic resonance imaging system, the magnetic resonance imaging system (100) comprising: —a memory (134, 136) storing machine executable instructions (160, 162, 164), pulse sequence commands (140) and a first machine learning model (146) comprising a first deep learning network (502), wherein the pulse sequence commands (140) are configured for controlling the magnetic resonance imaging system (100) to acquire a set of magnetic resonance imaging data, wherein the first machine learning model (146) comprises a first input and a first output, —a processor, wherein an execution of the machine executable instructions (160, 162, 164) causes the processor (130) to control the magnetic resonance imaging system (100) to repeatedly perform an acquisition and analysis process comprising: —acquiring a dataset (142.1, . . . , 142.

Abstract: A cartridge assembly (2, 200) for use in an aerosol-generating system comprises: a cartridge (4) having an upstream end and a downstream end, the cartridge (4) comprising: at least one compartment (12, 14) having an air inlet at the upstream end of the cartridge (4) and an air outlet downstream of the air inlet; a removable first seal (20) secured to the upstream end of the cartridge (4), wherein the removable first seal (20) obstructs the air inlet of the at least one compartment (12, 14) and is configured to be removed by a user prior to use of the cartridge assembly (2); and a cartridge actuation portion (18) on an inner surface of a downstream end portion of the cartridge (4).

Abstract: An actuation pressure to actuate one or more hydraulic actuators may be determined based on a load on the one or more hydraulic actuators of a robotic device. Based on the determined actuation pressure, a pressure rail from among a set of pressure rails at respective pressures may be selected. One or more valves may connect the selected pressure rail to a metering valve. The hydraulic drive system may operate in a discrete mode in which the metering valve opens such that hydraulic fluid flows from the selected pressure rail through the metering valve to the one or more hydraulic actuators at approximately the supply pressure. Responsive to a control state of the robotic device, the hydraulic drive system may operate in a continuous mode in which the metering valve throttles the hydraulic fluid such that the supply pressure is reduced to the determined actuation pressure.

Abstract: A method and apparatus are disclosed for providing a compression fixation between a first and further component. The apparatus comprises an elongate body having a head end and a tip end and comprising a screw thread including a first region in which the screw thread has a corresponding first pitch and a further region, extending from the tip end, in which the screw thread is tapered and has a corresponding farther pitch that continually decreases away from the tip end.

Abstract: An embodiment of an automatic key delivery system is described, An automatic key delivery system comprises the following operations. Herein, a first token is generated and provided to a first network device. Thereafter, a first key value pair, including the first token and a first key segment of a cryptographic key, is received by a first relay server and a second key value pair, including the first token and a second key segment of the cryptographic key, is received from a second relay server. In response, a second token to be provided to the first relay server and the second relay server. Thereafter, the first and second key segment are returned from the first and second relay servers based on usage of the second token as a lookup in order to recover the cryptographic key for decryption of an encrypted content from the first network device.

Abstract: A mechanism is provided to remove heat from an integrated circuit (IC) device die by directing heat through a waveguide to a heat sink. Embodiments provide the waveguide mounted on top of a package containing the IC device die. The waveguide is thermally coupled to the IC device die. The waveguide transports the heat to a heat sink coupled to the waveguide and located adjacent to the package on top of a printed circuit board on which the package is mounted. Embodiments provide both thermal dissipation of the generated heat while at the same time maintaining good radio frequency (RF) performance of the waveguide.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

Abstract: A membrane, method and system are disclosed for rapid, sensitive and precise detection of an agent suspected of being present in a sample. The agent may be a cell or microorganism, e.g., a single pathogenic bacteria, and the sample may be small, e.g., milliliters of unprocessed environmental water. The sample is processed by filtering it through an asymmetric membrane having multiple layers. One layer has microchannels for capturing the agent and another layer has nanochannels for passing particles smaller than the agent. Amplification reagents, such as loop-mediated isothermal amplification (LAMP) reagents, are load onto membrane so that the microchannels act as nanoreactors, creating quantifiable amplicons within the pores on the exposed surface of the membrane in response to captured agent. The amplicons may be imaged and counted using a fluorescent camera. The membrane is capable of agent capture, concentration, purification, partition, lysis and digital LAMP without off-membrane sample treatments.

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

Abstract: In a method for distributed upload of documents an upload email address is assigned to a user and associated with a searchable document database accessible by the user via a user device and a network. Sender acceptance criteria are established for the upload email address. An email addressed to the upload email address and having a sender email address is received from an email sender via the network. A determination is made as to whether the received email meets sender acceptance criteria. Responsive to a determination that the email meets sender acceptance criteria, documents attached to the email are identified. Each identified document is associated with a document record comprising a document identifier and a sender identifier associated with the email sender and is stored in the searchable document database with the document record.

Abstract: A computer-implemented method of detecting abnormal events in a telecommunication system can include a training phase and a production phase. The training phase can include recording data events in a log file during the execution of the system and creating a standard for the data events representing a properly working environment of the telecommunication system by applying a training procedure. The production phase can include receiving at least one new data event and determining whether the at least one new data event is a normal event that matches the standard or not. If the at least one new data event matches the standard, it can be used for updating the standard. If the at least one new data event does not match the standard, it can be classified and reported as at least one an abnormal event.