Patents by Inventor Michael Oren Delaney

Michael Oren Delaney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING
    Publication number: 20180142236
    Abstract: The present invention provides synthetic single guide RNAs that comprise two separate functional sequences (commonly known as crRNA and tracrRNA) connected by a linker. These synthetic single guide RNA molecules are useful in gene editing when used with RNA-guided endonucleases such as cas9 in eukaryotic cells. The availability of the synthetic single guide RNAs makes the screening for gene editing in high-through-put format simple and convenient.
    Type: Application
    Filed: April 7, 2016
    Publication date: May 24, 2018
    Inventors: Kaizhang He, Emily Marie Anderson, Michael Oren Delaney
  • Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides
    Patent number: 8759508
    Abstract: The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: June 24, 2014
    Assignee: GE Healthcare Dharmacon, Inc.
    Inventor: Michael Oren Delaney
  • NOVEL CHROMOPHORIC SILYL PROTECTING GROUPS AND THEIR USE IN THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES
    Publication number: 20100216984
    Abstract: The present invention provides compounds of the formula (I): C-Q-O—Si(R1)(R2)—N wherein C is a chromophore; Q is selected from the group consisting of optionally substituted aliphatic, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R1 and R2 are independently selected from the group consisting of optionally substituted C1-8 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-8 alkyloxy, cycloalkyloxy, heterocycloalkyloxy, alkylsilyloxy and arylsilyloxy; and N is a glycosylamine or abasic moiety.
    Type: Application
    Filed: May 16, 2008
    Publication date: August 26, 2010
    Applicant: Dharmacon, Inc.
    Inventor: Michael Oren Delaney