Abstract: A fluid diverting module includes a multi-position fluid diverting device comprising three-dimensional movable flow-paths with minimal tortuosity in the movable portion (the rotor) of the fluid diverting device. In some embodiments, the device is also equipped with a filtration module that is capable of filtering solid particulates from fluidic samples. The invention relates to an area of non-disruptive sampling from various sample sources including ones containing solids. The fluid diverting device maintains fluid communication between the sample source and a pressure creating device in all positions of the fluid diverting device, thus conserving the pressure inside the sample source during sampling. The sampling operation is controlled from a controller, which is equipped with a software for manual or intelligent control.

Abstract: A multidimensional chromatographic assembly includes a chromatographic medium selector module, which receives a sample from an injector module and moves the sample through one of at least two chromatographic media of a chromatographic medium module using at least one eluent from at least one fluid moving module. At least a portion of the sample is re-circulated through the same or the second chromatographic medium using a multi-configuration fluid diverting module, which isolates a selected portion of the chromatographed eluent containing at least a portion of the sample in at least one fluid holding compartment and later moves the isolated portion through one of the chromatographic media in an iterative manner until all attributes of the isolated portion in question are analyzed.

Abstract: A multidimensional chromatographic assembly includes a pump module, an injector, a path selector device, an array of chromatographic media, a loop selector device and a detector assembly for receiving at least a portion of an analyte stream and flowing the injected stream into the detector assembly via a chromatographic medium (the first dimension). At least a portion of the analyte of interest is then channeled into a chromatographic medium of interest (the second dimension) and re-circulated through the detector assembly. The iteration (multidimension) is continued until all aspects of the chromatogram and the peaks are judged to be analyzed. The entire process is controlled from a computer and the results are collected to make decisions on the analytical and the process controls.

Abstract: A sampling module of a fluid processing apparatus includes at least one multi-configuration device connected to a filtration module. The invention relates to an area of non-disruptive sampling from any flow stream including the ones containing solids. The fluid processing apparatus remains in fluid communication with a sample processing module in all configurations of the sampling module and the parameters deemed critical for a chemical process remain unaffected during the sampling event. The entire event is controlled from a computer and the results are collected to make decisions on analytical and process controls.

Abstract: A fluid diverting module includes a multi-position fluid diverting device comprising three-dimensional movable flow-paths with minimal tortuosity in the movable portion (the rotor) of the fluid diverting device. In some embodiments, the device is also equipped with a filtration module that is capable of filtering solid particulates from fluidic samples. The invention relates to an area of non-disruptive sampling from various sample sources including ones containing solids. The fluid diverting device maintains fluid communication between the sample source and a pressure creating device in all positions of the fluid diverting device, thus conserving the pressure inside the sample source during sampling. The sampling operation is controlled from a controller, which is equipped with a software for manual or intelligent control.

Abstract: A multidimensional chromatographic assembly includes a pump module, an injector, a path selector device, an array of chromatographic media, a loop selector device and a detector assembly for receiving at least a portion of an analyte stream and flowing the injected stream into the detector assembly via a chromatographic medium (the first dimension). At least a portion of the analyte of interest is then channeled into a chromatographic medium of interest (the second dimension) and re-circulated through the detector assembly. The iteration (multidimension) is continued until all aspects of the chromatogram and the peaks are judged to be analyzed. The entire process is controlled from a computer and the results are collected to make decisions on the analytical and the process controls.

Abstract: A sampling module of a fluid processing apparatus includes at least one multi-configuration device connected to a filtration module. The invention relates to an area of non-disruptive sampling from any flow stream including the ones containing solids. The fluid processing apparatus remains in fluid communication with a sample processing module in all configurations of the sampling module and the parameters deemed critical for a chemical process remain unaffected during the sampling event. The entire event is controlled from a computer and the results are collected to make decisions on analytical and process controls.

Abstract: A fluid processing assembly includes a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.

Abstract: A fluid processing assembly comprises a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.

Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

Abstract: Disclosed are novel quinazolinone derivatives of formula: wherein: R1 is optionally substituted phenyl or optionally substituted heteroaryl; R2 is 3-hydroxy, 4-hydroxy, 3-NHR4 or 4-NHR4, in which R4 is hydrogen, —C(O)R5, —C(O)NHR6, or —SO2R6; in which R5 is optionally substituted lower alkyl or optionally substituted lower alkoxy; and R6 is optionally substituted lower alkyl; R3 is hydrogen, lower alkyl, lower alkoxy, or halo; V is oxygen, sulfur, or —NH—; and W is lower alkylene of 1-3 carbon atoms, which are useful as ALDH-2 inhibitors for treating mammals for various disease states, such as treatment for cocaine dependency and alcohol dependency.

Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

Abstract: Disclosed are novel quinazolinone derivatives, useful as ALDH-2 inhibitors for treating mammals for various disease states, such as treatment for cocaine dependency or alcohol dependency.

Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

Abstract: Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.

Abstract: A reactor apparatus includes at least one reaction capillary having a lumen for receiving a reactant to undergo a reaction, and a magnetron for irradiating reactant contained in at least a portion of the capillary with microwaves. A method of micro-reacting a reactant includes providing a capillary, and irradiating the reactant in the capillary with microwaves to facilitate a chemical reaction in the capillary by which the reactant is converted into a desired product.

Abstract: The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

Abstract: Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.

Abstract: A method for preparing a substrate for a planographic printing plate is disclosed. A liquid that contains water; a soluble alkali metal silicate, preferably sodium silicate; and a dispersed particulate material is coated on a substrate, preferably aluminum or an aluminum alloy, to produce a hydrophilic layer on the substrate. A layer of image material may be coated over the substrate to produce a planographic printing plate. In one embodiment the liquid contains a mixture of two particulate materials: alumina and titanium dioxide.